A cohort study on risk factors for carotid atherosclerosis and prediction of cardiovascular risk

颈动脉粥样硬化危险因素及心血管风险预测的队列研究

• 批准号: 12470092
• 负责人: TANIGAWA Takeshi
• 金额: $ 9.09万
• 依托单位: University of Tsukuba
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2000
• 资助国家: 日本
• 起止时间: 2000 至 2001
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-12470092/
• 关键词: Carotid atherosclerosis; Risk factors; Genctic polymorphisms; 頚動脈硬化; 血漿フィブリノーゲン; 単球; 接着分子

We have conducted cross-sectional and prospective nested-case control studies to investigate risk factors for carotid atherosclerosis and the predictive value of carotid atherosclerosis for the risk of caridiovascular disease. The subjects were 234 men aged 60-74 in Akita rural community, 506 men aged 60-74 in Ibaraki rural community, 302 men aged 60-74 in Kochi rural community, 229 men aged 60-74 in the suburb of Osaka, 3,998men and women aged 40-74 in Suita city of which 1,761 men and women were surveyed again after 2 to 6 years of the baseline survey.Strong risk factors for carotid atherosclerosis were hypertension, hypercholesterolemia and smoking and these association were more evident when the values in the past surveys were taken into account. Inflamatory makers, I.e., serum high-sensitive C-reactive and an adhesion molecle, I.e. serum E selectin were associated significantly with carotid atherosclerosis. Polymorphism of angiotensionogen gene were not associated with carotid atherosclerosis.Incident stroke cases tended to have higher intima-media thickness in carotid arteries than controls. However, the number of cases were limted and the multivariate analysis was not conducted. In conclusion, the examination of carotid atherosclerosis is a promising procedure to evaluate atherosclerosis and maybe to predict the risk of stroke among Japanese.

我们进行了横断面和前瞻性巢式病例对照研究，以探讨颈动脉粥样硬化的危险因素以及颈动脉粥样硬化对心血管疾病风险的预测价值。研究对象为秋田农村社区 60-74 岁男性 234 名、茨城农村社区 60-74 岁男性 506 名、高知农村社区 60-74 岁男性 302 名、大阪郊区 60-74 岁男性 229 名、3,998 名男性吹田市40岁至74岁女性，其中1,761名男性和女性在2至20日再次接受调查基线调查为期 6 年。颈动脉粥样硬化的重要危险因素是高血压、高胆固醇血症和吸烟，如果考虑到过去调查的数值，这些关联性就更加明显。炎症因子，即血清高敏 C 反应性和粘附分子，即血清E选择素与颈动脉粥样硬化显着相关。血管紧张素基因多态性与颈动脉粥样硬化无关。中风病例的颈动脉内膜中层厚度往往高于对照组。但病例数有限，未进行多变量分析。总之，颈动脉粥样硬化检查是评估动脉粥样硬化的一种有前途的方法，并可能预测日本人中风的风险。

项目成果

北村明彦, 他: "地域住民における頚動脈硬化所見の出現状況とその関連要因に関する疫学的研究"脳卒中. 22. 320-328 (2000)

Akihiko Kitamura 等：“当地居民颈动脉硬化发生情况及相关因素的流行病学研究” 中风。

Mannami T. et al.: "Comparison of the prevalence of asymptomatic carotid atherosclerosis detected by high-resolution ultrasonography in rural and urban middle-aged men"J Stroke and Cerebrovascular Disease. 9. 106-112 (2000)

Mannami T.等人：“农村和城市中年男性高分辨率超声检测无症状颈动脉粥样硬化患病率的比较”J Stroke and Cerebroangiodisease。

Mannami T. et. Al: "Low potentiality of angiotensin-converting enzyme(ACE) gene insertion/deletion(I/D) pdymorphism as a useful marker for carotid atherogenesis in a large population of a Japanese city : The Suita Study"Stroke. 21. 1250-1256 (2001)

Mannami T.等。

Mannami T, et.al.: "Low potentiality of angiotensin -converting enzyme (ACE) gene insertion deletion (I/D) pdymorphism as a useful predictire marker for carotid atherogenesis in a large general population of a Japanese city : Suita Study."Stroke. (in pres

Mannami T 等人：“血管紧张素转换酶 (ACE) 基因插入缺失 (I/D) 多态性作为日本城市大量普通人群中颈动脉粥样硬化形成的有用预测标记的潜力较低：吹田研究。”

Mannami T. et. Al: "Strong and significant relationship between aggregation of major coronary risk factors and the acceleration of carotid atheroscrerosis in the general population of a Japanese city : The Suita Study"Arch Intern Med. 160. 2294-2303 (2000

Mannami T.等。