Does oral ingestion of nutrients during exercise interfere with the blood flow to exercising skeletal muscles?

运动期间口服营养物质是否会干扰运动骨骼肌的血液流动？

• 批准号: 14380017
• 负责人: SADAMOTO Tomoko
• 金额: $ 5.31万
• 依托单位: Japan Women's College of Physical Education, Department of Physical Education (2003)Nara Women's University (2002)
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2002
• 资助国家: 日本
• 起止时间: 2002 至 2003
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-14380017/
• 关键词: glucose; arterial blood pressure; superior mesenteric artery blood flow; Doppler ultrasound technique; handgrip exercise; postexercise ischemia; muscle metaboreflex; splanchnic circulation; 上腸間膜動脈血流; グルコース摂取; 筋虚血; フルクトース

Nutrient ingestion induces a profound increase in the splanchnic blood flow because the gastrointestinal organs lemand energy supply for digesting and absorbing the nutrients ingested. On the contrary, exercise stimulus causes a decrease in the splanchnic blood flow to drive a lager portion of cardiac output to the exercising skeletal muscles. It has not yet been known which signal between nutrition and exercise has a priority when these opposite signals occurred simultaneously It is also unclear how the cardiovascular system compromises these conflicting demands during exercise. The pin-pose in the present study is to investigate these questions. In the first experiments : We determined whether oral ingestion of glucose and fructose increased the blood flow in superior mesenteric artery (SMA), one of major arteries supplied to the gastrointestinal tract, during rest and sustained static exercise. Ten healthy female volunteers orally ingested 100-140 ml of 5 % of glucose or fructose so … More lution during rest. The blood flow in SMA (SMBF) was measured by Doppler ultrasound technique, and heart rate and arterial blood pressure measured by ECG and Finapres methods. It was found that the glucose ingestion produced a significant increase in SMBF approximately 15 mm after the ingestion, whereas the fructose ingestion had no effects on SMBF despite the identical volume and concentration in both drinks. In the second experiments : These subjects also joined the experiments to perform sustained static handgrip exercise at 30 % of maximum voluntary contraction for 2 mm before and after ingestion of 5 % glucose solution. The results showed that the exercise did not change SMBF from the resting level and rather increased slightly at the end of sustained exercise. The slight increase in SMBF was significantly greater during exercise after glucose ingestion than that during the exercise before glucose ingestion. These results indicated that drinking glucose solution was probably more powerful stimulus than the exercise stimulus. The SMA might be to some degree exempt from flow-reducing participation during exercise. In the third experiments : The results in the first experiments raise a question whether SMA was not a target vessel for the muscle metaboreflex arising from exercising skeletal although the muscle metaboreflex has been believed to induce a reduction in the splanchnic vascular beds. To verify this question, we examined the effects of postexercise muscle ischemia on SMBF. The subjects performed the same static exercise as mentioned in the first experiments and followed by a 3-min arterial occlusion. The arterial occlusion was done by pressure cuff inflation above 22OmmHg applied to the upper arm of exercised forearm. The postexercise ischemia showed a significant increase in SMBF in both exercise performed before and after glucose ingestion. The increase in SMBF observed during postexercise muscle ischemia was in parallel with the significant increase in arterial blood pressure. From these results, it appeared that SMA was not sensitive to the muscle metaboreflexes and that the profound increase in SMBF during postexercise ischemia was related to the elevation of arterial blood pressure. Less

营养摄入会引起示意性血流的大幅增加，因为胃肠道器官legand能量供应可消化和吸收摄入的营养营养素。相反，运动刺激会导致示意性血流减少，使心脏输出的啤酒部分驱动到运动骨骼肌肉。当这些相反的信号同时发生时，尚不知道营养和运动之间的哪个信号优先考虑，尚不清楚心血管系统如何损害运动过程中这些矛盾的需求。本研究中的PIN姿势是研究这些问题。在第一个实验中：我们确定口腔摄入葡萄糖和果糖是否会增加肠系膜上动脉（SMA）的血流，这是在休息和持续静态运动期间提供给胃肠道的主要动脉之一。十名健康的女性志愿者口服摄入100-140毫升5％的葡萄糖或果糖，因此……休息期间更多。通过多普勒超声技术测量SMA（SMBF）的血流，以及通过ECG和Finapres方法测量的心率和动脉血压。发现摄入后约15 mm的SMBF摄入显着增加，而尽管两种饮料的体积和浓度相同，但果糖摄入对SMBF没有影响。在第二个实验中：这些受试者还加入了实验，在摄入5％葡萄糖溶液之前和之后，在最大自愿收缩的30％中以最大自愿收缩的30％进行持续的静态手绘运动。结果表明，该练习并没有从静息水平改变SMBF，而在持续运动结束时略有增加。在麸酶摄入后运动过程中，SMBF的略大增加明显大于葡萄糖摄入之前的运动中。这些结果表明，饮用葡萄糖溶液可能比运动刺激更强大。 SMA可能在某种程度上免于运动过程中的减少流量参与。在第三个实验中：第一个实验的结果提出了一个问题，尽管据信肌肉代谢反射剂会诱导血管床的减少，但锻炼骨骼而引起的肌肉代谢反射是否不是目标血管。为了验证这个问题，我们检查了运动后肌肉缺血对SMBF的影响。受试者进行了与第一个实验中提到的相同的静态运动，然后进行了3分钟的伪像。人工制品是通过施加在运动前臂上部的22ommhg上方的压力袖口通胀来完成的。运动后缺血在葡萄糖摄入之前和之后进行的两种运动中的SMBF显着增加。运动后缺血期间观察到的SMBF的增加与动脉血压的显着升高平行。从这些结果来看，SMA似乎对肌肉代谢反射不敏感，并且运动后缺血期间SMBF的大幅增加与动脉血压升高有关。较少的

项目成果

Sadamoto Tomoko: "Superior mescenteric artery blood flow during static exercise and postexercise muscle ischemia."Advances in Exercise and Sports Physiology. 94. 172 (2003)

Sadamoto Tomoko：“静态运动和运动后肌肉缺血期间的上中动脉血流。”运动和运动生理学的进展。