Does oral ingestion of nutrients during exercise interfere with the blood flow to exercising skeletal muscles?

运动期间口服营养物质是否会干扰运动骨骼肌的血液流动？

基本信息

批准号：
14380017
负责人：
SADAMOTO Tomoko
金额：
$ 5.31万
依托单位：
Japan Women's College of Physical Education, Department of Physical Education (2003)Nara Women's University (2002)
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (B)
财政年份：
2002
资助国家：
日本
起止时间：
2002 至 2003
项目状态：
已结题

项目摘要

Nutrient ingestion induces a profound increase in the splanchnic blood flow because the gastrointestinal organs lemand energy supply for digesting and absorbing the nutrients ingested. On the contrary, exercise stimulus causes a decrease in the splanchnic blood flow to drive a lager portion of cardiac output to the exercising skeletal muscles. It has not yet been known which signal between nutrition and exercise has a priority when these opposite signals occurred simultaneously It is also unclear how the cardiovascular system compromises these conflicting demands during exercise. The pin-pose in the present study is to investigate these questions. In the first experiments : We determined whether oral ingestion of glucose and fructose increased the blood flow in superior mesenteric artery (SMA), one of major arteries supplied to the gastrointestinal tract, during rest and sustained static exercise. Ten healthy female volunteers orally ingested 100-140 ml of 5 % of glucose or fructose so … More lution during rest. The blood flow in SMA (SMBF) was measured by Doppler ultrasound technique, and heart rate and arterial blood pressure measured by ECG and Finapres methods. It was found that the glucose ingestion produced a significant increase in SMBF approximately 15 mm after the ingestion, whereas the fructose ingestion had no effects on SMBF despite the identical volume and concentration in both drinks. In the second experiments : These subjects also joined the experiments to perform sustained static handgrip exercise at 30 % of maximum voluntary contraction for 2 mm before and after ingestion of 5 % glucose solution. The results showed that the exercise did not change SMBF from the resting level and rather increased slightly at the end of sustained exercise. The slight increase in SMBF was significantly greater during exercise after glucose ingestion than that during the exercise before glucose ingestion. These results indicated that drinking glucose solution was probably more powerful stimulus than the exercise stimulus. The SMA might be to some degree exempt from flow-reducing participation during exercise. In the third experiments : The results in the first experiments raise a question whether SMA was not a target vessel for the muscle metaboreflex arising from exercising skeletal although the muscle metaboreflex has been believed to induce a reduction in the splanchnic vascular beds. To verify this question, we examined the effects of postexercise muscle ischemia on SMBF. The subjects performed the same static exercise as mentioned in the first experiments and followed by a 3-min arterial occlusion. The arterial occlusion was done by pressure cuff inflation above 22OmmHg applied to the upper arm of exercised forearm. The postexercise ischemia showed a significant increase in SMBF in both exercise performed before and after glucose ingestion. The increase in SMBF observed during postexercise muscle ischemia was in parallel with the significant increase in arterial blood pressure. From these results, it appeared that SMA was not sensitive to the muscle metaboreflexes and that the profound increase in SMBF during postexercise ischemia was related to the elevation of arterial blood pressure. Less

营养诱导了血液流量的大量增加，因为胃肠机诱饵能量可以消化，并在相反的情况下摄入营养这也是锻炼过程中那些相互矛盾的需求的心血管系统。在休息和静态运动中，十个健康的女性志愿者在休息期间摄入了100-140毫升的5％发现葡萄糖在摄入后15毫米的SMBF摄入显着增加，尽管两种饮料的体积和收缩相同，但在自愿摄取的30％之前和之后，对SMBF没有影响。摄入百分比的葡萄糖溶液表明，在持续运动结束时，该运动不会改变SMBF，而SMBF的略有增加是在葡萄糖摄入后明显增加的结果表明，醉酒解决方案可能更强大的刺激刺激刺激。一直以下是hnic the smbf的血管床。 22 mmHg应用于运动后缺血的上部。对于肌肉的代谢反射和静脉丛期间SMBF的大幅增加与动脉血压的升高有关。