Why the arterial blood pressure increases during exercise? -A role of muscle mechanoreflex-

为什么运动时动脉血压会升高？

基本信息

批准号：
08680117
负责人：
SADAMOTO Tomoko
金额：
$ 1.6万
依托单位：
Graduate School of Human Culture, Nara Women's University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
1996
资助国家：
日本
起止时间：
1996 至 1998
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-08680117/
关键词：
blood pressure heart rate central command overground locomotion mechanical load change 負荷変化予測教示内容 Locomotion Central descending signal Decerebrate cat カテコールアミン機械的情報反射性制御

项目摘要

EXPERIMENT I. To examine whether the cerebrum is essential for producing the rapid cardiovascular adjustment at the beginning at overground locomotion, we examined heart rate (HR), mean arterial blood pressure (MAP), and integrated electromyogram (iEMG) of the forelimb triceps brachialis muscle during locomotion in freely-moving decerebrate cats. Two to four days after decerebration surgery performed at the level of precollicular-premammillary body, the animals would spontaneously produce overground locomotion supporting body weight. HR began to increase immediately before the onset of iEMG, and MAP began to rise almost simultaneously with the iEMG onset. Their increases in HR and MAP(24 * 3 bpm and 22 * 4 mmHg) were sustained during locomotion. Sinoaortic denervation (SAD) did not affect the abrupt changes in HR and MAP at the beginning of locomotion (0-4 s from the onset of iEMG), whereas SAD had a contrasting effect during the subsequent period, a decrease in the HR response (9 * 1b … More pm) and an increase in the MAP response (30 * 3 mmHg). These results suggest that the cerebrum an the rostral part of the diencephalon are not essential for producing the rapid cardiovascular adjustment at the beginning of spontaneous overground locomotion. The arterial baroreflex does not contribute this rapid adjustment but play an important role in regulating the cardiovascular responses during the later period of spontaneous locomotion.EXPERIMENT II. To examine the role of a sudden load change on the cardiovascular adjustments during the bicycling exercise. Fifteen healthy female volunteers performed the same bicycling exercise which included one abrupt change of load-up or load-down under three different conditions in which the preliminary instructions about the load change given verbally before the bicycling exercise were no, true or false. The true and false instructions both produced anticipatory increases in HR and MAP observed 30 s before the onset of the load change, whereas no instruction did not alter them. After the onset of load-up or load-down, the cardiovascular responses to true instruction were more rapid than to other instructions. These results suggest that preliminary instructive preparation for voluntary exercise could modify the cardiovascular adjustment to the abrupt load changes. Less

实验I。要检查脑在开始时在地球运动时产生快速的心血管调节至关重要，我们检查了前肢三头三头肌肌肉肌肉的心率（HR），平均动脉血压（MAP）和综合的肌电图（IEMG）。在前后预性体内进行脑外科手术后的两到四天，这些动物将不含生产的生产在地面上，从而支持体重。人力资源在IEMG发作之前就开始增加，并与IEMG发作几乎同时开始上升。在运动期间，它们在HR和MAP（24 * 3 bpm和22 * 4 mmHg）中的增加。中学的神经区神经（SAD）并不影响运动开始时的HR和MAP的突然变化（从IEMG发作开始），而SAD在随后的时期内有鲜明的效果，HR响应的降低（9 * 1B…更多）（9 * 1B…更多），并且MAP响应的增加（30 * 3 MMHG）。这些结果表明，大脑和息肉的延髓部分对于在发起人地面运动开始时产生快速的心血管调节至关重要。动脉压力反射并不贡献这种快速调整，而是在赞助商 - 洛克莫蒂（Locomotion）的后期调查心血管反应中起重要作用。体验II。要检查骑自行车运动过程中突然负荷变化对心血管调节的作用。十五位健康的女性志愿者进行了相同的骑自行车运动，其中包括在三种不同条件下突然更改负载或减轻负荷的变化，在这种情况下，关于骑自行车练习之前，关于载荷变化的初步说明是否，是还是错误。在负载变化开始前30 s观察到的人力资源和地图的真实和虚假指令都产生了预期的增加，而没有指示不会改变它们。加载或减轻负载开始后，对真实指导的心血管反应比其他说明更快。这些结果表明，自愿运动的初步教学准备可以改变心血管调整，从而改变突然的负载变化。较少的