Differences in cardiovascular responses to exercise between children with hypertensive parents and children with normotensive parents.

父母患有高血压的孩子和父母血压正常的孩子之间心血管对运动的反应存在差异。

基本信息

批准号：
05680087
负责人：
SADAMOTO Tomoko
金额：
$ 1.28万
依托单位：
Nara Women's University
依托单位国家：
日本
项目类别：
Grant-in-Aid for General Scientific Research (C)
财政年份：
1993
资助国家：
日本
起止时间：
1993 至 1995
项目状态：
已结题

项目摘要

The present study investigated if cardiovascular responses during static and dynamic exercises might be different between children with hypertensive parents and children with normotensive parents. Twenty healthy females whose parents had been in essential hypertension (H-group) and 20 age-matched normotensive females whose parents were both normotensive (N-group) served as subjects in EXP I.Both groups performed a 2-min sustained static knee extension of which intensity was 30 % of maximal voluntary contraction (MVC). There was no difference between H- and N-groups in body size, body fat, resting arterial mean blood pressure (MAP) , heart rate (HR) , cardiac output (CO) and total peripheral resistance (TPR). Increases of MAP during static exercise in both groups were also identical. However, there were clear differences in component factors of MAP (i.e., CO and TPR). CO during exercise in H-group was significantly lower than that in N-group while TPR in H-group was significantly higher … More than that in N-group. Thus, the increased MAP in H-group was caused by the elevated TPR while that in N-group was induced by the elevated CO.Forearm blood flow and forearm skin blood flow measured during static exercise indicated that vascular beds in skeletal muscles and cutaneous tissues showed identical responses to exercise in both groups. Therefore, the increased TPR in H-group was induced by increased vasoconstriction in vascular beds except for skeletal muscles and cutaneous tissues, which were probably splanchinic and renal beds. In EXP II,different twenty-one females and 18 females respectively served as subjects for H- and N-groups whose age, body size, body fat and resting MAP were identical. Both groups performed a 20-min bicycling exercise of which intensity increased every 5 min. from 20%, 40%, 60% to 80% of maximal exercise (Loadmax). During 60% and 80% Loadmax cardiovascular responses were different between two groups although oxygen consumption was identical in both groups. MAP in H-group increased significantly greater than that in N-group. The increased MAP in H-group during higher intensities was also caused by increased TPR,probably due to greater vasoconstriction in splanchinic and renal vascular beds. These results from EXPs I and II suggest that the cardiovascular responses to both static and dynamic exercises in H-group are different from those in N-group while the subjects in H-group are now healthy and normotensive. Less

本研究调查了在静态和动态运动中的心血管反应是否在患有高血压父母和正常父母的孩子之间可能有所不同。二十名健康的女性，父母患有本质高血压（h组）和20岁年龄匹配的正常潮汐女性，父母的父母都是正常的下腹部（N组）作为Exp i.Both组的受试者，其强度为2分钟的静态膝关节，其中强度为最大自愿合同（MVC）的30％。 H-组和N组之间的体型，体内脂肪，静息动脉平均血压（MAP），心率（HR），心脏输出（CO）和总周围耐药性（TPR）没有差异。两组静态运动过程中MAP的增加也相同。但是，MAP的组件因子（即CO和TPR）存在明显的差异。在H组中进行运动期间的CO明显低于N组中的CO，而H组中的TPR显着高……大于N组中的TPR。这是由TPR升高引起的H组中图的增加，而N组中的升高是由升高的co升高的Forearm血液流量和前臂皮肤血流在静态运动过程中测得的，表明骨骼肌和皮肤组织中的血管床在两组中表现出相同的运动反应。因此，除骨骼肌肉和皮肤组织外，血管收缩的血管收缩增加可能是h-group中增加的TPR，这些血管收缩可能是模态和肾脏床。在EXP II中，不同的二十一名女性和18名女性作为H群和N组的受试者，他们的年龄，体型，体内脂肪和静止图相同。两组进行了20分钟的骑自行车运动，强度每5分钟增加一次。从20％，40％，60％到最大运动的80％（LoadMax）。两组之间的60％和80％的载荷心血管反应在两组之间有所不同，尽管两组的氧气消耗均相同。 H组中的MAP比N组显着增加。在较高强度期间，H组中的MAP增加也是由于TPR增加引起的，这可能是由于示意图和肾血管床的血管收缩更大所致。 Exp I和II的这些结果表明，H组中对静态和动态练习的心血管反应与N组中的静态练习和动态练习不同，而H组中的受试者现在健康且具有敏感性。较少的