Differences in cardiovascular responses to exercise between children with hypertensive parents and children with normotensive parents.

父母患有高血压的孩子和父母血压正常的孩子之间心血管对运动的反应存在差异。

基本信息

批准号：
05680087
负责人：
SADAMOTO Tomoko
金额：
$ 1.28万
依托单位：
Nara Women's University
依托单位国家：
日本
项目类别：
Grant-in-Aid for General Scientific Research (C)
财政年份：
1993
资助国家：
日本
起止时间：
1993 至 1995
项目状态：
已结题

项目摘要

The present study investigated if cardiovascular responses during static and dynamic exercises might be different between children with hypertensive parents and children with normotensive parents. Twenty healthy females whose parents had been in essential hypertension (H-group) and 20 age-matched normotensive females whose parents were both normotensive (N-group) served as subjects in EXP I.Both groups performed a 2-min sustained static knee extension of which intensity was 30 % of maximal voluntary contraction (MVC). There was no difference between H- and N-groups in body size, body fat, resting arterial mean blood pressure (MAP) , heart rate (HR) , cardiac output (CO) and total peripheral resistance (TPR). Increases of MAP during static exercise in both groups were also identical. However, there were clear differences in component factors of MAP (i.e., CO and TPR). CO during exercise in H-group was significantly lower than that in N-group while TPR in H-group was significantly higher … More than that in N-group. Thus, the increased MAP in H-group was caused by the elevated TPR while that in N-group was induced by the elevated CO.Forearm blood flow and forearm skin blood flow measured during static exercise indicated that vascular beds in skeletal muscles and cutaneous tissues showed identical responses to exercise in both groups. Therefore, the increased TPR in H-group was induced by increased vasoconstriction in vascular beds except for skeletal muscles and cutaneous tissues, which were probably splanchinic and renal beds. In EXP II,different twenty-one females and 18 females respectively served as subjects for H- and N-groups whose age, body size, body fat and resting MAP were identical. Both groups performed a 20-min bicycling exercise of which intensity increased every 5 min. from 20%, 40%, 60% to 80% of maximal exercise (Loadmax). During 60% and 80% Loadmax cardiovascular responses were different between two groups although oxygen consumption was identical in both groups. MAP in H-group increased significantly greater than that in N-group. The increased MAP in H-group during higher intensities was also caused by increased TPR,probably due to greater vasoconstriction in splanchinic and renal vascular beds. These results from EXPs I and II suggest that the cardiovascular responses to both static and dynamic exercises in H-group are different from those in N-group while the subjects in H-group are now healthy and normotensive. Less

本研究调查了 20 名父母患有原发性高血压（H 组）的健康女性和 20 名年龄匹配的血压正常的女性，父母患有高血压的儿童和父母血压正常的儿童在静态和动态运动中的心血管反应是否存在差异。血压均正常（N 组）作为 EXP I 中的受试者。两组均进行 2 分钟持续静态膝关节伸展，其强度为最大自主收缩 (MVC) 的 30%。H- 之间没有差异。两组在静态运动期间的体型、体脂、静息动脉平均血压（MAP）、心率（HR）、心输出量（CO）和总外周阻力（TPR）也均增加。相同，但 MAP 的构成因素（即 CO 和 TPR）存在明显差异，H 组运动时的 CO 显着低于 N 组，而 H 组的 TPR 显着高于……在因此，H 组中 MAP 的增加是由 TPR 升高引起的，而 N 组中 MAP 升高是由 CO 升高引起的。静态运动时测量的前臂血流量和前臂皮肤血流量表明骨骼中的血管床。两组的肌肉和皮肤组织对运动表现出相同的反应，因此，除了骨骼肌和皮肤组织（可能是内脏组织）外，H组中TPR的增加是由血管床血管收缩增加引起的。在EXP II中，不同的21名女性和18名女性分别作为H组和N组的受试者，两组的年龄、体型、体脂和静息MAP均相同。其中强度每 5 分钟从最大运动量 (Loadmax) 的 20%、40%、60% 增加到 80%，尽管在 60% 和 80% Loadmax 期间两组之间的心血管反应不同。两组的耗氧量相同。H 组的 MAP 增加显着大于 N 组。H 组在较高强度下 MAP 的增加也是由 TPR 增加引起的，可能是由于内脏和肾血管的血管收缩更大。 EXP I 和 II 的这些结果表明，H 组对静态和动态运动的心血管反应与 N 组不同，而 H 组的受试者现在健康且血压正常。