Search for Bioactive Natural Products from Unexplored Medicinal Resources

从未开发的药用资源中寻找具有生物活性的天然产物

基本信息

批准号：
14370716
负责人：
ISHIBASHI Masami
金额：
$ 7.3万
依托单位：
Chiba University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (B)
财政年份：
2002
资助国家：
日本
起止时间：
2002 至 2004
项目状态：
已结题

项目摘要

In this study, we constructed a naturally-occurring small-molecule library using unexplored medicinal resources such as marine algae, myxomycetes, and tropical plants, and carried out a screening study searching for bioactive substances which may be expected as leading molecules for drug developments.1)Marine organisms : About 100 species of marine algae were collected at Boso Peninsula, and their extracts were examined against antimicrobial activity, Artemia salina toxicity, and collagenase inhibitory activity. Among them, a phlorotannin and an antimicrobial plastoquinone were isolated from brown algae Ishige okamurae and Sargassum yamadae, respectively. About 30 species of nudibranchs were also collected at Boso Peninsula, and new terpenoid constituents were obtained from Dermatobranchus otome.2)Myxomycetes : We studied spore germination experiments of hundreds of field-collected myxomycetes collected in Japan and succeeded in laboratory culture of plasmodia of several myxomycetes in … More a practical scale for natural products chemistry studies. As a result, we isolated pyrroloiminoquinones, polyene yellow pigments, and a peptide lactone from cultured plasmodia of Didymium iridis, Physarum rigidum, and P.melleum, respectively. A new antimicrobial naphthoquinone, new cycloanthranilylprolines, cell-cycle inhibitory bisindoles, and a cytotoxic triterpenoid aldehyde lactone were also isolated from field-collected fruit bodies of Cribraria purpurea, Fuligo candida, Tubifera casparyi, and Tubifera dimorphotheca, respectively.3)Plants : We investigated a screening program against cytotoxicity and cell-cycle inhibitory activity using almost 300 species of tropical plants extracts collected from Khon Kaen area of Thailand. Among them, we isolated a diterpene with cell-cycle inhibitory activity from Blumea glomerata (Compositae) and its absolute configuration was revised. A new cytotoxic steroidal hexasaccharaide and a series of new sesquiterpene dimers were obtained from Agave faurcroydes (Agavaceae) and Curcuma parviflora (Zingiberaceae), respectively. A new pregnane alkaloid with cytotoxic activity against vincristine-resistant murine leukemia P388 cells was isolated from Wrightia javanica (Apocynaceae). Less

在这项研究中，一个原子质的小分子图书馆未开发的药物资源，例如海洋藻类和热带植物，并进行了筛查研究，以搜索生物活性物质TS。并检查了提取物，抗抗毒性盐酸盐毒性和胶原酶抑制活性。数百种野外收集的日本粘液菌在几种粘菌菌的严重程度中取得了成功，这是自然产物化学研究的实际规模。。从泰国的Khon Kaen区域收集的植物是由blumeata隔离的，其绝对构型被修订。抗鼠白血病p388细胞是从Wrightia Javanica（apocynaceae）中分离出来的

项目成果

期刊论文数量（58）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Y.Misono: "Dihydrolindbladiones, Three New Naphthoquinone Pigments from a Myxomycete Lindbladia tubulina"Journal of Natural Products. 66. 999-1001 (2003)

Y.Misono：“二氢林德布拉迪昂，来自粘菌林德布拉迪亚微管藻的三种新萘醌颜料”天然产物杂志。

DOI：
发表时间：
期刊：
影响因子：
0
作者：
通讯作者：

ツビフェラールAおよびツビフェラールB

块茎A和块茎B

DOI：
发表时间：
2010
期刊：
影响因子：
0
作者：
通讯作者：

Tubiferal A, a Backbone-Rearranged Triterpenoid Lactone Isolated from the Myxomycete Tubifera dimorphotheca, Posessing Reversal of Drug Resistance Activity

Tubiferal A，一种从双形粘菌 Tubifera dimorphotheca 中分离出来的主链重排三萜内酯，具有逆转耐药性活性

DOI：
发表时间：
2004
期刊：
Tetrahedron 60
影响因子：
0
作者：
Helene Ameln;Thomas Gustafsson;Carl Johan Sundberg;Kensaku Okamoto;Lorenz Poellinger;Eva Jansson;Yuichi Makino;牧野雄一;T.Ohtsuki;K.Toume;K.Kamata
通讯作者：
K.Kamata

Cribrarione B, a new naphthoquinone pigment from the myxomycete Cribraria cancellata