Histopathological Study for the Development of Adhesive Resin Systems with a Calcification Promoting Function as a Direct Pulp Capping Agent

开发具有钙化促进功能的粘合树脂系统作为直接盖髓剂的组织病理学研究

基本信息

批准号：
10470409
负责人：
KATOH Yoshiroh
金额：
$ 2.94万
依托单位：
Nippon Dental University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (B).
财政年份：
1998
资助国家：
日本
起止时间：
1998 至 2000
项目状态：
已结题

项目摘要

The results of a histopathological study of direct pulp capping in Macaca fascicularis suggested that adhesive resins caused no irritation to the pulp tissue or if so, it was extremely low and differences were found among the materials. When the pulp was protected and safely covered by direct capping using appropriate selected adhesive resins. New dentin formed on the exposed surface of the pulp and it should extend to the complete dentin bridge in the maturation process over time. It was also suggested that no inorganic cement was necessary as the material of the sub-base and base after Ca(OH)_2 hybridization with adhesive resin. Concerning the irrigation effect of dentinal chips between the alternate cleansing agents of 3%H_2O_2-6%NaOCl and 7%H_2O_2-10%NaOCl, higher concentrations of the agents did not always show better cleansing effect or wound healing properties of the pulp. Regarding the laser irradiation effect on the exposed pulp surface, no wound healing effect was actively re … More cognized of irradiation conditions used in this experiment. With the assistance of two manufactures, a histopathological study for the development of adhesive resin systems with a calcification promoting function as a direct pulp capping agent was examined. To summarize, the following experimentally developed materials : PR2B and PR2 groups in the Phenyl-P system and polymers containing 3%, 5% and 10% Ca(OH)_2 in the 4-META/MMA-TBB system showed a high possibility to be used as direct pulp capping agents. With the consent of the patients, the long-term clinical prognosis of the pulp directly or indirectly capped with adhesive resins on accidentally exposed pulp or pink spots found on the pulpal wall in deeply prepared cavities during conservative treatment was investigated. In total, seventeen teeth of 15 patients were capped directly and the remaining one was capped indirectly. The exposed size of the pulp was approximately 0.7mm in average. Long-term clinical prognosis, approximate 4 years in average of sixteen teeth of 13 patients (88.9%) was extremely good. Devitalization of the pulp with pulp necrosis was observed in two teeth of 2 patients (11.1%). The long-term clinical results clearly supported the results obtained in the previous studies. Namely, the results suggested that adhesive resins caused extremely low irritation to the pulp tissue. But differences between the materials were found.To conclude, it was clearly confirmed that adhesive resin is an appropriate material for use in certain cases as a direct pulp capping agent in clinic. At the same time, further investigation on both pulp diagnosis and the restorative pattern of teeth will be required. Less

麦卡卡筋膜中直接纸浆限额的组织病理学研究结果表明，粘合剂树脂对纸浆组织没有刺激，或者如果是的，则非常低，并且在材料中发现了差异。当果肉受到保护并通过适当选择的粘合树脂直接封盖保护并安全地覆盖时。在纸浆的裸露表面形成的新牙本质，随着时间的推移，它应在成熟过程中延伸至完整的牙本质桥。还建议不需要无机水泥作为Ca（OH）_2与粘合剂树脂后基碱基和碱基的材料。关于3％H_2O_2-6％NaOCl和7％H_2O_2-10％NAOCL的替代清洁剂之间牙齿芯片的灌溉作用，较高浓度的药物并不总是显示出更好的清洁效果或PULP的伤口愈合特性。关于激光辐照对裸露的纸浆表面的效果，没有积极地重新恢复伤口愈合作用……更认识到本实验中使用的辐射条件。在两个制造业的帮助下，研究了一项针对具有直接纸浆封盖剂计算促进功能的粘合树脂系统开发的组织病理学研究。总而言之，以下实验开发的材料：4-META/MMA-TBB系统中包含3％，5％和10％Ca（OH）_2的苯基P系统中的PR2B和PR2基团显示出很高的可能性，可以用作直接纸浆封剂限量。在患者的同意下，研究了在保守治疗期间，在果肉壁上直接或间接用粘合剂树脂在果肉壁上发现的意外暴露的果肉或粉红色斑点上直接或间接覆盖的纸浆临床预后。总共将17名患者的17颗牙齿直接封闭，其余的牙齿被暗中封闭。果肉的暴露尺寸平均约为0.7mm。长期临床预后，16例患者的16颗牙齿平均为4年（88.9％）非常好。在2例患者的两颗牙齿中，观察到果肉均以果肉坏死的遗嘱（11.1％）。长期临床结果清楚地支持了先前研究中获得的结果。也就是说，结果表明粘合剂对纸浆组织引起极低的刺激。但是发现了材料之间的差异。包括，清楚地证实，粘合树脂是在某些情况下用作诊所直接纸浆封盖剂的合适材料。同时，将需要进一步研究牙髓诊断和牙齿的恢复模式。较少的