INVESTIGATION OF HUMAN BRAIN FUNCTION USING MICRO-SQUID.

使用微型鱿鱼研究人脑功能。

• 批准号: 09558102
• 负责人: KAKIGI Ryusuke
• 金额: $ 7.04万
• 依托单位: OKAZAKI NATIONAL RESEARCH INSTITUTE
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B).
• 财政年份: 1997
• 资助国家: 日本
• 起止时间: 1997 至 2000
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-09558102/
• 关键词: Micro; SQUID; Magnetoencephalography; MEG; Resolution; Brain function; Vision; Somatosensory; 脳磁図; 脳波; SQUID; 言語; 顔; 痛覚; 磁場; 末梢神経; 脳機能; 超小型; 脊髄

We developed a new multi (twelve) - channel gradiometer system with the smallest and highest quality superconducting quantum interference device (micro-SQUID). A very small distance (3.80 mm) between the sensor coils and the skin provides quite high spatial resolution. Since this was the newly-developed machine, at first, we had to solve many small problems in terms of hardware, software, and magnetic shielded room. Finally, it took approximately 2 and a half years to solve all problems. Then we started the experiments from 1999.The first study was published in Neurosciecne Letters in 1999 concerniong peripheral nerve function. The actual whole image of the sensory nerve action fields (NAF) of the human median nerve at the wrist were successfully recorded following digital nerve stimulation by using the micro-SQUID.The NAF showed the biphasic waveform at each of the 12 channels, and the isomagnetic field map clearly showed the moving quadrupole pattern. The quadrupole comprised a dipole for depolarization followed by another dipole with the opposite direction for repolarization. The polarized length of the nerve obtained by reconstructing the magnetic field maps was approximately 17 cm, and the magnetic field complex moved along the nerve from the distal to the proximal part of the wrist at 58.7 m/s.

我们开发了一个新的多（十二） - 通道梯度计，具有最小，最高质量的超导量子干扰装置（微分方）。传感器线圈和皮肤之间的距离很小（3.80毫米）可提供很高的空间分辨率。由于这是新开发的机器，因此起初，我们必须解决许多小问题，软件，软件和磁性屏蔽室。最后，解决了所有问题大约花了大约2年半的时间。然后，我们从1999年开始进行实验。首次研究发表在1999年的Neurosciecne字母中，Chressiong外周神经功能。通过使用微分方的数字神经刺激后，成功记录了人类中位神经的感觉神经动作场（NAF）的实际整体图像。NAF在12个通道中显示了双相波形，同性磁场图清楚地显示了移动的四倍图杆模式。四极杆包含用于去极化的偶极子，然后是另一个偶极子，其方向相反。通过重建磁场图获得的神经的偏振长度约为17厘米，磁场复合物沿着神经从腕部的远端移动到手腕的近端，以58.7 m/s的速度移动。

项目成果

Kakigi R, Watanabe S, Yamasaki H.: "The pain-related Somatosensory evoked potentials."Journal of Clinical Neurophysiology. 17. 295-308 (2000)

Kakigi R、Watanabe S、Yamasaki H.：“与疼痛相关的体感诱发电位。”临床神经生理学杂志。

Kakigi R: "Watanabe S. : Pain-related Somatosensoryevoked potentials following CO_2 laser stimulation."Pain Forum. 7. 185-187 (1998)

Kakigi R：“Watanabe S.：CO_2 激光刺激后与疼痛相关的体感诱发电位。”疼痛论坛。

Watanabe S,Kakigi R: "Pain processing traced by magnetoencephalography in the human brain." Brain Topography. 10.4. 255-264 (1998)

Watanabe S、Kakigi R：“通过脑磁图追踪人脑中的疼痛处理。”

Kakigi R et al: "The somatosensory evoked magnetic fields."Progress in Neurobiology. 61. 495-523 (2000)

Kakigi R 等人：“体感诱发磁场。”神经生物学进展。

Maeda K, Kakigi R, et al: "Mapping of receptive fields in the secondary somatosensory cortex in humans : a magnetoencephalographic study"NeuroReport. 10. 301-306 (1999)

Maeda K、Kakigi R 等人：“人类次级体感皮层感受野的映射：一项脑磁图研究”NeuroReport。