Investigation of intracerebral processing of various somatosensory stimuli, mainlu painand itch.

各种体感刺激、主路痛、痒的脑内处理研究。

• 批准号: 22300135
• 负责人: KAKIGI Ryusuke
• 金额: $ 11.4万
• 依托单位: National Institute for Physiological Sciences
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010-04-01 至 2013-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22300135/
• 关键词: 痛み; 痒み; 体性感覚; 脳波; 脳磁図; 機能的MRI; MRI; 触覚; 視覚; 注意; ニコチン; 喫煙

Concerning pain perception in humans, we developed a new stimulus electrode for selectively stimulating pain-specific receptors of the skin. This needle is highly evaluated throughout the world, and many researchers and clinicians are now using this not only for basic studies but also for clinical application.Regarding itch perception in humans, we clarified intra-cerebral mechanisms for the following two unique phenomena: (1) Itch is contagious: When we look at other persons' skin appearing very itchy, we also feel that our skin is itchy and sometimes desire to scratch. (2) Feeling pleasantness while scratching itchy skin: When we scratch itchy skin, we usually feel pleasantness and desire to continue. We found that the reward system in our brain is activated in such a case.

关于人类的疼痛感知，我们开发了一种新的刺激电极，用于选择性刺激皮肤的疼痛特异性受体。 This needle is highly evaluated throughout the world, and many researchers and clinicians are now using this not only for basic studies but also for clinical application.Regarding itch perception in humans, we clarified intra-cerebral mechanisms for the following two unique phenomena: (1) Itch is contagious: When we look at other persons' skin appearing very itchy, we also feel that our skin is itchy and sometimes desire to scratch. （2）挠痒的皮肤时感到愉悦：当我们刮擦皮肤发痒时，我们通常会感到愉悦和渴望继续下去。我们发现在这种情况下，我们大脑中的奖励系统被激活。

项目成果

Pain and itch perception in humans.

人类的疼痛和瘙痒感知。

• 发表时间: 2016
• 作者: 吉田礼;曽根;引地健生理;町田好男;Kakigi R
• 通讯作者: Kakigi R

ヒトの痛みと痒みの脳内認知機構の解明

阐明人类疼痛和瘙痒的大脑认知机制

• 发表时间: 2010
• 作者: T. Owaki;柿木隆介
• 通讯作者: 柿木隆介

Somatotopic representation of pain in the primary somatosensory cortex (S1) in humans

• DOI: 10.1016/j.clinph.2013.01.006
• 发表时间: 2013-07
• 期刊: Clinical Neurophysiology
• 影响因子: 4.7
• 作者: S. Omori;S. Isose;N. Otsuru;Makoto Nishihara;S. Kuwabara;K. Inui;R. Kakigi

Painful and itchy brain.

大脑又痛又痒。

• 发表时间: 2013
• 作者: 酒井宏治;久和茂;池郁生;駒瀬勝啓;竹田誠;網康至;Kakigi R
• 通讯作者: Kakigi R

The painful brain

痛苦的大脑

• 发表时间: 2012
• 作者: 林佳霈,佐藤多加之;Chou Hung P.;谷藤学;春野 雅彦;Ike Fumio;根本知己;Kakigi R
• 通讯作者: Kakigi R