ATOMIC MAGNETOMETER FOR FETAL BIOMAGNETISM

用于胎儿生物磁学的原子磁力计

• 批准号: 7778253
• 负责人: THAD G WALKER
• 金额: $ 26.82万
• 依托单位: UNIVERSITY OF WISCONSIN-MADISON
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-03-01 至 2013-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7778253
• 关键词: Adult; Arrhythmia; Color; Electronics; Goals; Magnetoencephalography; Maintenance; Measurement; Methods; Noise; Optics; Performance; Pregnant Women; Research; Signal Transduction; Squid; System; Technology; Testing; Ultrasonography; base; biomagnetism; cost; design; fetal; fetal diagnosis; human subject; improved; magnetic field; miniaturize; novel; programs; public health relevance; vector

DESCRIPTION (provided by applicant): The long-term goal of this research program is to develop an optical magnetometer for use in fetal magnetocardiography (fMCG) and fetal magnetoencephalography (fMEG) systems. We believe that the proposed magnetometer represents the first viable alternative to SQUID magnetometers; thus, the potential impact of the research on the field of biomagnetism is enormous. We have developed a novel, small-volume single-channel atomic biomagnetometer and have used it to detect adult MCG signals. The magnetometer has sufficiently high sensitivity that it is fetal MCG capable. The next step is to develop a practical multi- channel, multidimensional, low-cost atomic magnetometer for fMCG. The specific aims are: 1. To improve the noise performance of our single channel vector magnetometer to 20 fT/ Hz over a 1-100 Hz bandwidth. 2. To further miniaturize it to a 10 cm diagonal size with integrated optics and electronics, and to design and fabricate a four-channel atomic biomagnetometer suit- able for fMCG studies. 3. To test and evaluate the technical performance of the biomagnetometer array using phantoms. 4. To integrate the biomagnetometer within a test system that is compatible with studies of pregnant women. 5. To make preliminary human subject measurements with the multichannel system. PUBLIC HEALTH RELEVANCE: Fetal magnetocardiography is an especially effective method for diagnosis of fetal arrhythmias. It can provide information that is not available through other technologies such as ultrasound. The proposed research into a new atomic magnetometer for fetal magnetocardiography has the potential to greatly reduce the cost and improve the performance of fetal magnetocardiography.

描述（由申请人提供）：该研究计划的长期目标是开发一种用于胎儿心磁图（fMCG）和胎儿脑磁图（fMEG）系统的光学磁力计。我们相信，所提出的磁力计代表了 SQUID 磁力计的第一个可行替代方案；因此，该研究对生物磁学领域的潜在影响是巨大的。我们开发了一种新型小体积单通道原子生物磁力计，并用它来检测成人 MCG 信号。磁力计具有足够高的灵敏度，能够支持胎儿 MCG。下一步是开发实用的多通道、多维、低成本的 fMCG 原子磁力计。具体目标是： 1. 将我们的单通道矢量磁力计的噪声性能在 1-100 Hz 带宽内提高到 20 fT/Hz。 2. 进一步小型化至10 cm对角线尺寸，集成光学和电子学，并设计和制造适合fMCG研究的四通道原子生物磁力计。 3. 利用体模测试和评估生物磁力计阵列的技术性能。 4. 将生物磁力计集成到与孕妇研究兼容的测试系统中。 5. 利用多通道系统进行初步的人体测量。公众健康相关性：胎儿心磁图是诊断胎儿心律失常的特别有效的方法。它可以提供通过超声波等其他技术无法获得的信息。所提出的针对胎儿心磁图的新型原子磁力计的研究有可能大大降低成本并提高胎儿心磁图的性能。