Atomic Magnetometer For Fetal Biomagnetism

胎儿生物磁力原子磁力计

基本信息

批准号：
9292344
负责人：
THAD G WALKER
金额：
$ 30.61万
依托单位：
UNIVERSITY OF WISCONSIN-MADISON
依托单位国家：
美国
项目类别：
财政年份：
2009
资助国家：
美国
起止时间：
2009-03-01 至 2018-12-31
项目状态：
已结题

项目摘要

DESCRIPTION (provided by applicant): The long-term goal of this research program is to develop an optical magnetometer array for use in fetal magnetocardiography (fMCG) and fetal magneto-encephalography (fMEG) systems. The proposed magnetometer, based on recent advances in magnetometer technology, represents the first viable alternative to SQUID magnetometers; thus, the potential impact of the research on the field of biomagnetism is enormous. Utilization of fMCG and fMEG has been limited by the high cost of acquisition and maintenance associated with SQUID technology. The atomic magnetometer can mitigate these disadvantages while maintaining or even surpassing the magnetic field sensitivity of SQUID magnetometers. A novel, four-channel atomic biomagnetometer array was recently demonstrated for adult and fetal MCG studies. The next steps are to refine it for use in conventional magnetically shielded rooms and to extend its capabilities to inexpensive shielding geometries. The specific aims of this project are: 1. to demonstrate a 9-channel atomic magnetometer array for direct comparison to commercial SQUIDs for detection of signals from 20 week gestation period fetuses. 2. To extend the bandwidth and dynamic range of the atomic magnetometer for use in inexpensive shielding environments. 3. To make pre-clinical studies of at-risk fetuses with the magnetometer array. To achieve these aims, the researchers will investigate new modes of operation of the magnetometer that improve its bandwidth and dynamic range. New data processing methodologies will be considered, and the developments will be tested with human subjects.

描述（由申请人提供）：该研究计划的长期目标是开发用于用于胎儿磁心电图（FMCG）和胎儿磁脑线图（FMEG）系统的光学磁力计阵列。根据磁力计技术的最新进展，提出的磁力计代表了鱿鱼磁力计的第一个可行替代方案。因此，研究对生物磁化领域的潜在影响是巨大的。 FMCG和FMEG的利用受到与鱿鱼技术相关的高收购和维护成本的限制。原子磁力计可以减轻这些缺点，同时保持甚至超过鱿鱼磁力计的磁场灵敏度。最近在成人和胎儿MCG研究中证明了一个新型的四通道原子生物磁铁阵列。接下来的步骤是将其完善，以在传统的磁屏蔽房间中使用，并将其功能扩展到廉价的屏蔽几何形状。该项目的具体目的是：1。演示9通道原子磁力计阵列，以直接与商业鱿鱼进行直接比较，以检测20周妊娠期胎儿的信号。 2。扩展原子磁力计的带宽和动态范围，用于廉价屏蔽环境。 3。用磁力计阵列对处于危险的胎儿进行临床研究。为了实现这些目标，研究人员将研究磁力计的新操作模式，以改善其带宽和动态范围。将考虑新的数据处理方法，并将通过人类受试者进行发展。