Biomechanical regulation of cell shape, proliferation and cell death

细胞形状、增殖和细胞死亡的生物力学调节

• 批准号: 21870040
• 负责人: HAYASHI Takashi
• 金额: $ 1.76万
• 依托单位: National Institute of Genetics
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Research Activity Start-up
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-21870040/
• 关键词: 発生; 形態; 成長; 細胞死

The roles of biomechanics on cell shape control, proliferation and cell death were studied using Drosophila melanogaster as the model system. It has been shown that the shape of cells is under the control of surface tension, which is produced by cytoskeletons, by studying the effects of manipulating the function of Rho, Rac or non-muscle Myosin in vivo. An experimental system for studying the roles of biomechanics on proliferation or cell death has also been established.

以果蝇为模型系统，研究生物力学对细胞形状控制、增殖和细胞死亡的作用。通过研究体内操纵Rho、Rac或非肌肉肌球蛋白功能的效果，已经表明细胞的形状受到细胞骨架产生的表面张力的控制。还建立了研究生物力学对增殖或细胞死亡的作用的实验系统。

项目成果

ショウジョウバエ視細胞の形態決定過程を支配する分子メカニズムとその数理モデル

果蝇感光细胞形态决定过程的分子机制及其数学模型

• 发表时间: 2009
• 期刊: 生物物理 Vol.49、No.6
• 作者: Motoki Takaku;Takashi Kainuma;Takako Ishida-Takaku;et al.;林貴史
• 通讯作者: 林貴史