Evolution of drinking mechanism from aquatic to terrestrial habitat : Exploring its origin using fishes

从水生到陆地栖息地的饮水机制的演变：利用鱼类探索其起源

• 批准号: 19207005
• 负责人: TAKEI Yoshio
• 金额: $ 32.36万
• 依托单位: The University of Tokyo
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (A)
• 财政年份: 2007
• 资助国家: 日本
• 起止时间: 2007 至 2009
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-19207005/
• 关键词: 浸透圧調節; 飲水行動; ホルモン; 水生動物; 脳内神経回路; 浸透圧刺激; 容量刺激; ウナギ; アンジオテンシン; アドレノメデュリン; ナトリウム利尿ペプチド; ウロテンシン; グレリン; 血圧調整; 脳室周囲器官; 血圧調節; 循環調節; 腎作用

In this study, we found that guanylin, adrenomedullin and relaxin form a family of diversified members in teleost fishes and play important roles in osmoregulation, particularly in seawater adaptation. We also found that natriuretic peptides that suppress drinking and angiotensin that induces drinking act on the area postrema in the medulla oblongata to regulate reflex swallowing in aquatic fishes, which is in contrast to terrestrial animals where they regulate thirst by acting on the forebrain.

在这项研究中，我们发现鸟苷素、肾上腺髓质素和松弛素在硬骨鱼中形成了一个多样化成员的家族，在渗透调节中发挥着重要作用，特别是在海水适应中。我们还发现，抑制饮水的利钠肽和诱导饮水的血管紧张素作用于延髓后部区域，调节水生鱼类的反射性吞咽，这与陆生动物相反，陆生动物通过作用于前脑来调节口渴。

项目成果

The intestinal guanylin system and seawater adaptation in eels

鳗鱼的肠道鸟苷素系统和海水适应

• 发表时间: 2007
• 期刊: General and Comparative Endocrinology 152
• 作者: Takei;Y;et. al.
• 通讯作者: et. al.

Exporing novel hormones essential for seawater adaptation in teleost fish

揭示硬骨鱼适应海水所必需的新型激素

• 发表时间: 2008
• 期刊: General and Comparative Endocrinology 157
• 作者: Takei;Y.
• 通讯作者: Y.

Hagfish natriuretic peptide changes urine flow rates and vascular tensions in a hagfish

盲鳗利钠肽改变盲鳗的尿流量和血管张力

• 发表时间: 2009
• 期刊: Comparative Biochemistry and Physiology 150C
• 作者: Tait;L.W.;et.al.
• 通讯作者: et.al.

Potent cardiovascular actions of homologous adrenomedullins in eel

鳗鱼同源肾上腺髓质素的有效心血管作用

• 发表时间: 2008
• 期刊: American Journal of Physiology 294
• 作者: Nobata;S. ;et. al
• 通讯作者: et. al

Adrenomedullin 2 is a morepotent activator of hypothalamic oxytocin\secreting neurons than adrenomedullin in rats, and its effects are only partially blocked by antagonists for adrenomedullin and calcitonin gene-related peptide receptors

在大鼠中，肾上腺髓质素 2 是比肾上腺髓质素更有效的下丘脑催产素分泌神经元激活剂，其作用仅被肾上腺髓质素和降钙素基因相关肽受体的拮抗剂部分阻断

• 发表时间: 2007
• 期刊: Peptides 28
• 作者: Hashimoto;H.;et. al.
• 通讯作者: et. al.