Managements of anesthesia and solution for autologous transfusion

自体输血麻醉及溶液管理

基本信息

批准号：
06671552
负责人：
KOBORI Masao
金额：
$ 0.51万
依托单位：
Showa University
依托单位国家：
日本
项目类别：
Grant-in-Aid for General Scientific Research (C)
财政年份：
1994
资助国家：
日本
起止时间：
1994 至 1995
项目状态：
已结题

项目摘要

The effects of isoflurane concentration on the respirocirulatory system, the organ blood flow and oxygen tension of the left ventricular myocardium (pm02) were studied. The organ blood flow was measured in the renal cortex (RCBF), renal medulla (RMBF), liver (LBF) and muscle (MBF) by hydrogen clearance method and coronary blood flow (CBF) by electromagnetic flow probe. In our results, the organ blood flow decreased sygnificantly as compared to the control values according to the depth of anesthesia in both normal group and hemodilution group. RCBF, RMBF, MBF, CBF and Pm02 decreased more markedly in hemodilution group in which circulatory system and the organ blood flow were depressed more markedly according to the depth of anesthesia.We divided subjects under halothane anesthesia into the normal group and hemodilutional group. In both groups, control values of respiratory and circulatory parameters and coronary blood flow (CBF) were measured. We repeated these measurements after subjects had beed anesthtized by two different methods : halothane hypotensive anesthesia and trinitroglycerine hypotensive anesthesia. Differing from these findings, under trinitroglycerine hypotensive anesthesia no differrence from the control values was observed in CBF in normal group, while in hemodilutional group CBF decreased significantly from the control value. It was indicated from our results that the increse in coronary blood flow induced by trinitroglycerine becomes obscure under hemodilutional state.

研究了异氟烷浓度对呼吸驱动力系统，左心室心肌的器官血流和氧张力（PM02）的影响。通过电磁清除方法和冠状血流（CBF），通过电磁流量探测器测量了器官的血流在肾皮质（RCBF），肾脏髓质（RMBF），肝（LBF）和肌肉（MBF）中测量。在我们的结果中，根据正常组和血液稀释组的麻醉深度，与对照值相比，器官的血液流相比降低。 RCBF，RMBF，MBF，CBF和PM02在血压稀释组中更明显降低，其中循环系统和器官的血液流动根据麻醉的深度更明显地抑制。我们将甲黑烷麻醉下的受试者分为正常组和正常组。在这两组中，都测量了呼吸和循环参数的控制值以及冠状动脉血流（CBF）。在受试者通过两种不同的方法进行麻醉之后，我们重复了这些测量值：硫烷低血压麻醉和三硝基甘油降压性麻醉。与这些发现的不同之处，在三硝基甘油低血压麻醉下，正常组中CBF中观察到与对照值没有差异，而在血液释放的组中，CBF在CBF中均与对照值显着降低。从我们的结果表明，三硝基甘油诱导的冠状动脉血流中的增量在血液稀释状态下变得晦涩难懂。