Meaning and safety of hemodilutional autologous blood transfusion undr neurosurgery

神经外科血液稀释自体输血的意义和安全性

基本信息

批准号：
09671585
负责人：
KOBORI Masao
金额：
$ 1.66万
依托单位：
Showa University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
1997
资助国家：
日本
起止时间：
1997 至 1999
项目状态：
已结题

项目摘要

Intraoperative isovolemic hemodilution technique can be indicated in emergency cases such as in patients expected to undergo urgent neurosurgery. However, acute hemodilution is associated with a risk of increased intracranial pressure, given that the brain appears to be favored at the expense of the splanchnic organs in the resulting redistributrion of cardiac output.1) The aim of the present study was to evaluate the ICP, CaBF, CCBF and CMBF, responses to hyperventilation combined with isovolemic hemodilution in dogs. These results indicate that anesthesiologists should be well in the aggressive use of acute isovolemic hemodilution in patients so as to avoid an increase in cerebral blood flow.2) The aim of the present study was to evalute the hemodynamic and cerebral variables, in the responses to isoflurane induced hypotension combined with isovolemic hemodilution in dogs. These results indicate that, when combined with hemodilution, isoflurane acted as a hypotensive agent, at least regarding the cerebral variables.3) The aim of the present study was to evalute the hemodynamic and cerebral variables in responses to sevoflurane-induced hypotension combined with isovolemic hemodilution in dogs. These results indicate that anathesiologists should be attentive to cerebral variables when formed hypotension is induced by sevoflurane in patient undergoing neurosurgery. Similarly it involves using acute normovolemic hemodilution.4) The objective of this study was to evaluate systemic hemodynamic and cerebral responses dig isovolemic hemodilution alone and when combined with TNG- or PGE1-inducd hypotension in isoflurane anesthetized dogs. These results suggest that hypotensive anesthesia using PGE1 is more effective than TNG under hemodilution conditions, due to the improvement of myocardial contractile force and cerebral oxygen tension.

在紧急情况下，例如预期接受紧急神经外科手术的患者，可以指示术中的等体血液稀释技术。 However, acute hemodilution is associated with a risk of increased intracranial pressure, given that the brain appears to be favored at the expense of the splanchnic organs in the resulting redistributrion of cardiac output.1) The aim of the present study was to evaluate the ICP, CaBF, CCBF and CMBF, responses to hyperventilation combined with isovolemic hemodilution in dogs.这些结果表明，麻醉师应该在患者的急性等血液稀释症的积极使用方面表现良好，以免脑血流增加。2）本研究的目的是评估血液动力学和脑动力学变量，在对等异氟尿液诱导的低血压诱导的低血压组合中，与等异伏型血液脱落。这些结果表明，与血液稀释结合时，异氟烷至少充当脑变量。3）本研究的目的是评估对七氟氨酸诱导的低血压与狗的血液动力学和脑变量相结合的血液动力学和脑变量。这些结果表明，当形成低血压的患者在接受神经外科手术的患者中诱发六氟烷时，应注意脑变量。类似地，它涉及使用急性正常血液稀释性。4）本研究的目的是评估单独进行全身血液动力学和脑反应，而与tNG或PGE1-Inducd Hypotension相结合时，在异氟烷麻醉的狗中与TNG-或PGE1-INDUCD高血压结合。这些结果表明，由于心肌收缩力和脑氧张力的改善，使用PGE1的降压性麻醉比在血液稀释条件下更有效。