Physio-Pharmacological Effects of Analgesics and Sedatives on Respiratory Depression

镇痛药和镇静药对呼吸抑制的生理药理学作用

• 批准号: 06671510
• 负责人: ITO Yusuke
• 金额: $ 0.77万
• 依托单位: TOYAMA MEDICAL AND PHARMACEUTICAL UNIVERSITY
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for General Scientific Research (C)
• 财政年份: 1994
• 资助国家: 日本
• 起止时间: 1994 至 1995
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-06671510/
• 关键词: Respiration; Respiratory depression; Human volunteer; Benzodiazepine; Midazolam; Flumazenil; Heart rate spectral analysis; Stellate ganglion block; Human; Flumazenil; Respiratory depresion

In the first year, we investigated the effects of sevoflurane on the phrenic nerve discharge and the respiratory timing compared with those of halothane in cats. These findings demonstrated that sevoflurane has a weaker depressive effect on the respiratory nerve discharge and a smaller effect on the neural respiratory rate than halothane. This may be due to the lesser effect of sevoflurane on the vagal mediated and CO2-related mechanisms which modulate the global outputs of the central respiratory control systems (1).In the second year, we also investigated the respiratory effects of benzodiazepine (midazolam) in healthy volunteers. This data suggests that flumazenil reverses midazolam-induced sedation completely but is partially effective for some parameters related to respiratory depression (2). It also demonstrated the difference in midazolam-induced sedation and breathing patterns between male and female subjects with midazolam administration on a mg/kg basis (3).To investigate the cardiac autonomic nervous system related to respiratory depression, we conducted a preliminary study in healthy volunteers under right or left stellate ganglion block (SGB). The findings suggest that right SGB stimulates the cardiac autonomic nervous system and left SGB suppress it (4-6). We will study that effect of midazolam on the cardiac autonomic nervous system in due time.

在第一年，我们研究了七氟醚对猫神经排出和呼吸时序的影响，与猫中的卤烷相比。这些发现表明，与硫烷相比，Sevoflurane对呼吸道神经排出的抑郁作用较弱，对神经呼吸率的影响较小。这可能是由于Sevoflurane对迷走神经介导的和CO2相关的机制的影响较小，该机制调节了中央呼吸控制系统的全球输出（1）。在第二年中，我们还研究了苯二氮卓类（米达唑仑）在健康志愿者中的呼吸作用。该数据表明，氟马西尼完全逆转了咪达唑仑诱导的镇静作用，但对于与呼吸抑郁症有关的某些参数具有部分有效的效果（2）。它还证明了咪达唑仑诱导的镇静和女性受试者之间具有咪达唑仑的镇静模式的差异（3）。为了研究与呼吸道抑郁症有关的心脏自主神经神经系统，我们在右或左Stellate Stellate Ganglion Block（SGB）的健康志愿者中进行了初步研究。研究结果表明，右SGB刺激心脏自主神经系统，并使SGB抑制它（4-6）。我们将在适当的时候研究咪达唑仑对心脏自主神经系统的影响。

项目成果

A.Masuda: "Effects of sevoflurane on respiratory activities in the phrenic nerve of decerebrate cats." Acta Anaesthesiol Scand. 39. 774-781 (1995)

A.Masuda：“七氟醚对去大脑猫膈神经呼吸活动的影响。”

増田 明: "健常人におけるミダゾラムの呼吸抑制作用とフルマゼニルによる拮抗作用" 麻酔. 43. 722-727 (1994)

Akira Masuda：“健康受试者中咪达唑仑的呼吸抑制作用和氟马西尼的拮抗作用”麻醉，43. 722-727 (1994)。

A.Masuda: "Differences in midazolam-induced breathing patterns in healthy volunteers" Acta Anaesthesiologica Scandinavica. 39. 785-790 (1995)

A.Masuda：“健康志愿者中咪达唑仑引起的呼吸模式的差异”Acta Anaesthesiologica Scandinavica。

増田 明: "星状神経節ブロックによる洞停止の1症例-心拍変動の周波数解析から-" 麻酔. 44. 858-861 (1995)

Akira Masuda：“星状神经节阻滞导致窦性停搏的病例 - 来自心率变异性的频率分析 -”麻醉，44。858-861 (1995)

A.Masuda: "A transient sinus arrest after right stellate ganglion block-assessment of autonomic function by heart rate spectraol analysis-." Masui. 44. 858-861 (1995)

A.Masuda：“右星状神经节阻滞后，通过心率谱分析评估自主神经功能，出现短暂的窦性停搏。”