Transforming smartphones into active sonar systems to detect opioid overdose

将智能手机转变为主动声纳系统以检测阿片类药物过量

• 批准号: 9906080
• 负责人: Nicholas Maxwell Mark
• 金额: $ 22.35万
• 依托单位: SOUND LIFE SCIENCES, INC.
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-09-30 至 2020-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9906080
• 关键词: Acute; Algorithms; Antidotes; Apnea; Applications Grants; Biological Sciences; Breathing; Businesses; Capital; Cellular Phone; Cessation of life; Chest; Clinical; Clinical Research; Communication; Communities; Computer software; Coupling; Data; Data Analytics; Data Collection; Data Storage and Retrieval; Databases; Detection; Devices; Early Diagnosis; Emergency medical service; Engineering; Ensure; Epidemic; Equipment; Event; Family member; Feedback; Frequencies; Friends; Goals; Gold; Harm Reduction; Health Care Costs; Health Insurance Portability and Accountability Act; Health Services Accessibility; Human; Impairment; Individual; Infrastructure; Injections; Intervention; Life; Local Government; Manufacturer Name; Measures; Medical; Methods; Monitor; Movement; Naloxone; National Institute of Drug Abuse; Notification; Opioid; Overdose; Patient Monitoring; Performance; Phase; Public Health; Publishing; Recovery; Research; Research Personnel; Respiration; Respiratory Failure; Resuscitation; Risk; Running; Sales; Savings; Secure; Small Business Innovation Research Grant; Supervision; System; Techniques; Technology; Telephone; Testing; Therapeutic; Time; Training; Translational Research; United States; Ventilatory Depression; Vision; base; commercialization; cost; digital; experience; healthy volunteer; improved; innovation; meetings; microphone; mobile application; novel; opioid mortality; opioid overdose; opioid use; opioid use disorder; overdose risk; phase 2 study; portability; prototype; public health emergency; respiratory; response; signal processing; sonar; sound; treatment program; usability; Acute; Algorithms; Antidotes; Apnea; Applications Grants; Biological Sciences; Breathing; Businesses; Capital; Cellular Phone; Cessation of life; Chest; Clinical; Clinical Research; Communication; Communities; Computer software; Coupling; Data; Data Analytics; Data Collection; Data Storage and Retrieval; Databases; Detection; Devices; Early Diagnosis; Emergency medical service; Engineering; Ensure; Epidemic; Equipment; Event; Family member; Feedback; Frequencies; Friends; Goals; Gold; Harm Reduction; Health Care Costs; Health Insurance Portability and Accountability Act; Health Services Accessibility; Human; Impairment; Individual; Infrastructure; Injections; Intervention; Life; Local Government; Manufacturer Name; Measures; Medical; Methods; Monitor; Movement; Naloxone; National Institute of Drug Abuse; Notification; Opioid; Overdose; Patient Monitoring; Performance; Phase; Public Health; Publishing; Recovery; Research; Research Personnel; Respiration; Respiratory Failure; Resuscitation; Risk; Running; Sales; Savings; Secure; Small Business Innovation Research Grant; Supervision; System; Techniques; Technology; Telephone; Testing; Therapeutic; Time; Training; Translational Research; United States; Ventilatory Depression; Vision; base; commercialization; cost; digital; experience; healthy volunteer; improved; innovation; meetings; microphone; mobile application; novel; opioid mortality; opioid overdose; opioid use; opioid use disorder; overdose risk; phase 2 study; portability; prototype; public health emergency; respiratory; response; signal processing; sonar; sound; treatment program; usability

PROJECT SUMMARY/ABSTRACT Opioid use disorder (OUD) and mortality from opioid overdose are significant public health concerns. Deaths from opioid overdose are highly preventable with early detection and administration of naloxone. A key challenge of the epidemic is that overdose victims often die because they are alone or among untrained or impaired bystanders and thus do not receive timely resuscitation. There is an urgent, unmet need for a low-barrier, easily scalable solution that can identify opioid overdoses in real-time and rapidly connect victims to naloxone therapy. The goal of Sound Life Sciences’ (SLS) Fast-Track proposal is to commercialize an innovative overdose detection software product that can be downloaded on any commodity smartphone and can detect opioid- induced respiratory failure (i.e., overdose) and summon help. The software-only product, SecondChance, converts a smartphone into a short-range active sonar system capable of monitoring breathing and detecting overdose. SecondChance requires no additional hardware and leverages the native speaker/microphone array inside the phone and proprietary overdose detection signal processing algorithms. The software enables an individual to monitor themselves when they are at risk for an overdose and, in the event of an overdose, SecondChance can summon help, either from a friend or family member or from emergency medical services (EMS). Sound Life Sciences’ long-term goal is to keep individuals with OUD safe until they are able to access treatment and achieve durable recovery. In Phase I of this Fast-Track application, SLS will convert the SecondChance prototype (for which feasibility has been established) into a minimum viable product (MVP) based on rapid iteration guided by feedback and usability testing. In Phase II, using human factors engineering approaches, SLS will complete the SecondChance System and systematically validate each component: the patient monitoring app, the HIPAA-compliant data collection and storage infrastructure, and the emergency services integration. The Phase II studies will culminate in a 510(k) submission to the FDA. The SecondChance System will be marketed to naloxone manufacturers, local governments and people with OUD to ensure rapid dissemination to at-risk individuals. Given the number of people with OUD and costs associated with opioid overdose, there is a substantial market for the SecondChance System.

项目摘要/摘要 阿片类药物使用障碍（OUD）和阿片类药物过量的死亡率是公共卫生的重大问题。死亡人数 通过早期检测和纳洛酮给药可预防阿片类药物的过量。一个关键的挑战 流行病是因为滥用过量通常是因为他们是一个人或未经训练或受损 旁观者，因此没有及时复苏。对于低障碍，很容易满足的紧急，未满足的需求 可扩展的溶液可以实时鉴定阿片类药物过量并迅速连接到纳洛酮治疗的惊喜。 声音生命科学的目标（SLS）快速提案是商业化的过量 可以在任何商品智能手机上下载的检测软件产品，并且可以检测到Ooid- 诱发呼吸衰竭（即过量）和召唤帮助。仅软件的产品，第二次， 将智能手机转换为一个能够监视呼吸和检测的短距离活动声纳系统 过量。第二次不需要其他硬件，并且要利用母语/麦克风阵列 在手机内部和专有的过量检测信号处理算法。该软件使 当他们有过量的风险时，个人可以监视自己，并且在服用过量时， 第二次Chance可以从朋友或家人或紧急医疗服务召唤帮助 （EMS）。 Sound Life Sciences的长期目标是确保个人安全，直到能够访问 治疗并实现持久的恢复。在此快速轨道应用程序的第一阶段，SLS将转换 第二个原型（已建立可行性）为最低可行产品（MVP） 在反馈和可用性测试的指导下快速迭代。在第二阶段，使用人为因素工程 方法，SLS将完成第二次体系系统，并系统地验证每个组件： 患者监控应用程序，符合HIPAA的数据收集和存储基础架构以及出现 服务集成。 II期研究将在510（k）提交FDA中达到高潮。第二次 系统将被销售给纳洛酮制造商，地方政府和拥有OUD的人，以确保快速 向高危个人传播。鉴于与OOPOID相关的OUD人数和成本 服用过量，第二次体系有一个巨大的市场。