Low-Cost Mobile Detection of Opioid Overdose Events

阿片类药物过量事件的低成本移动检测

• 批准号: 10358652
• 负责人: Jacob Sunshine
• 金额: $ 19.02万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-03-15 至 2022-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10358652
• 关键词: Acute; Acute respiratory failure; Algorithms; Antidotes; Apnea; British Columbia; Caring; Cellular Phone; Clinical; Controlled Environment; Cost Savings; Data; Detection; Development; Devices; Diagnosis; Diagnostic; Early Diagnosis; Elements; Emergency medical service; Emergency treatment; Environment; Epidemic; Equipment; Event; Evolution; Feedback; Fentanyl; Future; General Anesthesia; Goals; Health; Hospitals; Human; Human Resources; Impairment; Individual; Injections; Intervention; Interview; K-Series Research Career Programs; Knowledge; Legal; Life; Measures; Medical; Medical emergency; Mentored Patient-Oriented Research Career Development Award; Mission; Modality; Modeling; Monitor; Morbidity - disease rate; Naloxone; Operating Rooms; Operative Surgical Procedures; Opioid; Outcome; Overdose; Participant; Patients; Persons; Physicians; Physiological; Population; Public Health; Qualitative Methods; Research; Respiratory Mechanics; Respiratory physiology; Running; Savings; Scientist; Short Interspersed Nucleotide Elements; Signal Transduction; Structure; Supervision; Supportive care; System; Technology; Time; Training; United States; United States Dept. of Health and Human Services; United States National Institutes of Health; Ventilatory Depression; base; chronic pain patient; cost; detection platform; disability; efficacy evaluation; experience; health care settings; high risk; innovation; interdisciplinary approach; mobile sensing; mortality; novel; novel strategies; opioid epidemic; opioid injection; opioid mortality; opioid overdose; opioid use; opioid use disorder; patient oriented research; patient safety; portability; preference; prevent; programs; randomized trial; respiratory; therapy design

PROJECT SUMMARY/ABSTRACT A fundamental challenge of the opioid epidemic is that overdose victims die because they are alone or among untrained or impaired bystanders. Yet opioid deaths are readily preventable with early detection and appropriate supportive care. As mortality continues to rise, new approaches are needed to prevent deaths from opioid overdose. The long-term goal of this research program is to develop low-cost, mobile overdose detection and signaling modalities to optimize outcomes in patients at high risk for opioid overdose. The overall objective of this specific proposal is to evaluate whether two existing, clinically validated, low-cost respiratory sensing systems can be modified to reliably detect overdose events. The central hypotheses are that: (1) existing, portable respiratory sensing systems can be modified to accurately detect the entire spectrum of abnormal respiratory mechanics arising from overdose events; and (2) high-risk individuals will use such a sensing system as a low-cost life-saving intervention. This K23 award is an essential element of my evolution as an independent physician scientist, as it will allow me to obtain new training in patient-oriented research and enable me to collect key preliminary data for a future, larger scale intervention. Guided by strong preliminary data on two existing mobile respiratory sensing systems, the central hypotheses will be investigated in 3 specific aims: Aim 1. Determine the feasibility of mobile, low-cost, non-invasive respiratory sensing systems to accurately identify rapid and prolonged apnea events in a safe, controlled, operating room setting, using induction of general anesthesia during elective surgery as an acute, fentanyl-induced overdose model; Aim 2. Determine the feasibility and preliminary efficacy of mobile sensing systems to detect opioid-induced respiratory depression and overdose events in a real-world opioid using population, in a pilot diagnostic study of participants self-injecting opioids in a supervised injection facility (SIF) in nearby Vancouver, BC; Aim 3. Measure stakeholder acceptance of using and disseminating mobile overdose detection technologies, using a qualitative approach involving structured interviews with opioid prescribers, chronic pain patients and people who inject opioids. The approach is innovative because it will utilize existing, low-cost mobile sensing systems to identify potentially lethal prolonged apnea events in humans, using induction of general anesthesia as a physiologic overdose model. The study will also be the first to utilize a SIF to measure the continuum of respiratory physiology generated from real-world opioid self-injection events. The proposed research is significant, because at the completion of the 3 Aims, the team will have obtained user feedback and generated the necessary data to implement a low-cost, truly ubiquitous system capable of identifying (and eventually signaling to EMS and bystanders) acute overdose events.

项目摘要/摘要 阿片类药物流行的基本挑战是，过量的受害者死亡，因为他们是一个人或中间的 未经训练或受损的旁观者。然而，通过早期检测很容易预防阿片类药物的死亡 适当的支持护理。随着死亡率继续上升，需要采取新的方法来防止死亡 阿片类药物过量。该研究计划的长期目标是开发低成本的移动过量 检测和信号传导方式可优化阿片类药物过量风险的患者的结局。总体 该特定建议的目的是评估是否存在两种现有的，临床验证的低成本呼吸道 可以修改传感系统以可靠地检测到过量的事件。中心假设是：（1） 可以修改现有的便携式呼吸传感系统，以准确检测整个光谱 过量事件引起的异常呼吸力学； （2）高风险个人将使用这样的 传感系统是一种低成本的挽救生命的干预措施。这个K23奖是我进化的基本要素 作为一名独立医师科学家，因为这将使我能够在以患者为导向的研究中获得新的培训 使我能够收集关键的初步数据，以进行未来的大规模干预。在强大的初步指导下 有关两个现有移动呼吸传感系统的数据，将在3中研究中心假设 具体目的： 目标1。确定移动，低成本，非侵入性呼吸传感系统的可行性 使用归纳 选修手术期间的全身麻醉作为急性，芬太尼诱导的过量模型； 目标2。确定移动传感系统检测阿片类药物诱导的可行性和初步功效 在一项试验诊断研究中 参与者在不列颠哥伦比亚省温哥华附近的有监督注射设施（SIF）中自我注射的阿片类药物； 目标3。衡量利益相关者接受使用和传播移动过量检测技术， 使用涉及阿片类药物处方者，慢性疼痛患者和 注射阿片类药物的人。 该方法具有创新性，因为它将利用现有的低成本移动传感系统来识别 使用全身麻醉作为生理学，可能致命的长期呼吸暂停事件， overdose model.该研究还将是第一个利用SIF测量呼吸道连续体的研究 由现实世界阿片类型自注射事件产生的生理学。拟议的研究很重要， 因为在完成3个目标时，团队将获得用户反馈并生成 必要的数据来实施一个能够识别的低成本，真正普遍存在的系统（最终 向EMS和旁观者发出信号）急性过量事件。

项目成果

Smart Speakers: The Next Frontier in mHealth.

• DOI: 10.2196/28686
• 发表时间: 2022-02-21
• 期刊: JMIR mHealth and uHealth
• 影响因子: 5
• 作者: Sunshine J