Socio-psychological Factors Concerned to 15 Years Long-term Outcome of First Onset Schizophrenics

与初发精神分裂症患者 15 年长期结局相关的社会心理因素

• 批准号: 06670966
• 负责人: OKAZAKI Yuji
• 金额: $ 1.15万
• 依托单位: Nagasaki University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for General Scientific Research (C)
• 财政年份: 1994
• 资助国家: 日本
• 起止时间: 1994 至 1995
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-06670966/
• 关键词: Schizophrenia; Long-term outcome; Follow-up study; Socio-psychological factor; Structured interview; Inter-rater reliability; 社会心理学的要因

This is a prospective long-term outcome study with the subjects of 107 first onset schizophrenic patients collected for an incidence study cohort. Assessment scales used structured interview have obtained adequate inter-rater reliability beforehand.The main results of the study are as follows :1.Morbidity outcome is 58 alive and 7 dead (a follow-up rate is 60.7%), and 42 drop-out (39.3%). The suicide (i.e., 4 cases and one suspected case) rate among the subjects is 6%-8%. Most of the drop-out cases have dropped out within 2 years after first contact, and follow-up rates were about 60% at the times of 2-year, 5-year, 10-year and 15-year follow-ups.2.Regarding the symptomatological outcome, at least 30% of the subjects have recoverd. This supports the results of other reports.3.Evaluating social outcome in general, 39.7% of them had "good" outcome and 55.2% "poor", and compared to the percentages given in other reports, they are about in the average.4.Concerning long-term course, episodic course was seen in about 40% of the subjects, continuous in about 40% and in-between course in about 20%.These results are also similar to the other reports. Looking at the symptomatological, social outcome and course evaluated in this study, it is reconfirmed that the outcome of schizophrenia is not necessarily poor and some cases have good outcome, while some cases keep a low-adjustment level showing psychotic symptoms continuously over a long period of time.As a future study projects, the relationship between various clinical factors (e.x., onset type, duration of period from the onset to the start of treatment, nature of onset symptoms, duration of first episode, early-stage treatment, etc.), socio-psychological factors before and after the onset and course/outcome will be studied.

这是一项前瞻性长期结果研究，受试者为发病率研究队列中收集的 107 名首次发病的精神分裂症患者。采用结构化访谈的评估量表事先已获得足够的评估者间信度。研究的主要结果如下：1.发病结果为58例存活，7例死亡（随访率为60.7%），42例退出（39.3%）。受试者自杀率（即4例和1例疑似病例）为6%-8%。大多数辍学病例在首次接触后2年内就已辍学，2年、5年、10年和15年随访时的随访率约为60%2。就症状结果而言，至少 30% 的受试者已经康复。这也支持了其他报告的结果。3.总体评价社会结果，39.7%的人结果“好”，55.2%的人“差”，与其他报告给出的百分比相比，他们大约处于平均水平。4关于长期病程，约40%的受试者出现间歇性病程，约40%为连续病程，约20%为中间病程。这些结果也与其他报告相似。从本研究评估的症状、社会结局和病程来看，再次证实精神分裂症的结局并不一定很差，有些病例结局良好，而有些病例则长期保持低调整水平，持续表现出精神症状作为未来的研究项目，各种临床因素之间的关系（例如，发病类型、从发病到开始治疗的持续时间、发病症状的性质、首次发作的持续时间、早期治疗、等），将研究发病前后的社会心理因素以及过程/结果。