Neuropsychological research on frontal lobe function in schizophrenia: A relationship between visual cognitive context and eye movements.

精神分裂症额叶功能的神经心理学研究：视觉认知背景与眼球运动之间的关系。

基本信息

批准号：
60480260
负责人：
OKAZAKI Yuji
金额：
$ 2.82万
依托单位：
University of Tokyo
依托单位国家：
日本
项目类别：
Grant-in-Aid for General Scientific Research (B)
财政年份：
1985
资助国家：
日本
起止时间：
1985 至 1986
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-60480260/
关键词：
Schizophrenia Frontal lobe function Cognitive Context Strategy Eye Movements Ambiguous figure

项目摘要

The purpose of this study is to investigate the frontal lobe function being reflected as a strategy or a process of 'context-updating' which is performed by schizophrenics, recording eye movements during the visual cognitive tasks. In the first step, we prepared a paradigm in which eye movements can be led to tracing strategies employed in processing visual stimuli, and devised the recording and analyzing system for the data of eye movements using the appratus (NAC, model V) and micro-computer (NEC, PC9801, VM2). Specifically, in order to explore the trends of visual information processing, we newly developed the computerized method by which on a screen we can examine the data of eye movements accumulated trial by trial, or subject by subject within a given stimulus pattern. In the second step, we conducted two kinds of experiments in which eye movements were recorded during tasks. Sixteen schizophrenic outpatients (mean age 39. 1 years) and 7 normal volunteers served as subjects. All … More schizophtrenics met the diagnostic criteria of DSM-III for schizophrenic disorders. In experiment I, the two kinds of ambiguous figures, i.e., "Duck and Rabbit" drawn by Jastrow and "Young Woman and Old Women" drawn by Boring, were employed as a stimuli. In one condition of this experiment I, subjects were required to perceive only the one aspect of each of ambiguous figures. In another condition, they were instructed to make an alternation between two different images evoked by a given figure, as correctly and quickly as possible. In experiment II, we employd the Neisser's visual search task and modified for this experiment. Prior to these experiments, Benton Visual Retention Test were administered for all subjects. As a result, we found that schizophrenic patients were mainly divided into the poor-performed group and the well-perrformed group. Especially, several of the schizophrenic subjects included in the latter group performed the tasks as well as normal subjects. These results claimed that neither the frontal lobe dysfunction nor the cognitive dysfunction in schizophrenics should be assesed collectively. Less

本研究的目的是调查额叶功能反映为精神分裂症患者执行的“情境更新”策略或过程，记录视觉认知任务期间的眼球运动。第一步，我们准备了一个范例。其中眼球运动可以引导到处理视觉刺激所采用的跟踪策略，并设计了使用设备（NAC，型号V）和微型计算机（NEC，具体来说，为了探索视觉信息处理的趋势，我们新开发了一种计算机化方法，通过该方法我们可以在屏幕上检查在给定刺激下逐个试验积累的眼动数据。第二步，我们进行了两种实验，记录了 16 名精神分裂症门诊患者（平均年龄 39. 1 岁）和 7 名正常志愿者作为受试者。实验一采用贾斯特罗画的“鸭子和兔子”和博林画的“少妇和老妇”两种模糊图形作为精神分裂症患者的诊断标准。在这个实验 I 的一种情况下，受试者被要求只感知每个模糊图形的一个方面，在另一种情况下，他们被要求在引起的两个不同图像之间进行交替。在实验 II 中，我们采用了 Neisser 视觉搜索任务，并在这些实验之前对所有受试者进行了本顿视觉保留测试。精神分裂症患者主要分为表现不佳组和表现良好组，特别是，后一组中的几名精神分裂症受试者执行的任务与正常受试者一样好。额叶功能障碍和精神分裂症患者的认知功能障碍应综合评估。