Multi-axial Physical Brain Examination on Schizophrenia.

精神分裂症的多轴物理脑检查。

基本信息

批准号：
63480259
负责人：
OKAZAKI Yuji
金额：
$ 3.26万
依托单位：
Nagasaki University
依托单位国家：
日本
项目类别：
Grant-in-Aid for General Scientific Research (B)
财政年份：
1988
资助国家：
日本
起止时间：
1988 至 1990
项目状态：
已结题

项目摘要

Three dimensional physical examination study was carried out on schizophrenics diagnosed by DSM-III and normal volunteers as the control.As the first dimension, CT data were sampled from SIEMENS SOMATOM CR scanner on the condition of digital data. Some fresh schizophrenics have showed diffuse low dencity CT-value, however, this finding was transitional and it's CT-value has showed recovered to the normal range.In the comparison between two group, mean CT density of the schizophrenics (N=47, 34.3<plus-minus>2.67) were significantly (p<0.05) lower than that of the control (N=13, 35.64<plus-minus>1As the second dimension, in the rCBF measurement using 1231-IMP SPECT with arterial blood sampling method, mean schizophrenic whole brain CBF (N=21, 62.7<plus-minus>19.3ml/100g/min) showed decreased from that of the control (N=30, 56.5<plus-minus>17.6ml/100g/mTherefore CBF is largely influenced by the aging, regression analysis was carried out, then the most suitable regression function (R-square=0.4997) was as follows ;CBF index = log (CBF) = 4.59-0.0129Xage.Mean corrected CBF index in the normal control was 4.21<plus-minus>0.22 (N=21), and it's distribution showed normal distribution (Wilk-Shapiro's test). On the other hand, that of the schizophrenics group was 3.98<plus-minus>0.38 (N=As the third dimension, EEG power examination (FFT analysis) was carried out by 16ch location. In the EEG study, remarkable changes in the schizophrenic patients were increase in the slow frequency band power (+1 to+21%up), fade down alpha activity, and significantly (P<0.05) increase of beta band activity.Throughout these three dimensional quantitative studies, neither regionality (including frontal lobe dysfunction) nor laterality was observed. Thus, we failed to reconfirm these hypotheses.However using these three dimensional plots, we might be able to discriminate schizophrenic cases from the normal objectively.

对由DSM-III和正常志愿者诊断为对照的精神分裂症患者进行了三维体格检查研究。作为对照，从西门子的Somatom somatom somatom cr扫描仪采样了CT数据，就数字数据的条件进行了采样。然而，一些新鲜的精神分裂症已经显示出弥漫性低的齿状CT值，但是，这一发现是过渡性的，它的CT值已显示出恢复到正常范围。在两组之间的比较中，精神分裂症的平均CT密度（n = 47，47，34.3 <plus-minus> 2.67）比（Plus-minus> 2.67）显着（P <0.05），n =（n = n =）， 35.64 <plus-minus> 1是第二维，在使用1231-IMP SPECT的RCBF测量中，带有动脉血液采样方法的平均精神分裂症全脑CBF（n = 21，62.7 <plus-minus> 19.3ml/100g/min）均与对照组显示出（n = 30，56.5 <MINS/56.5 <MM，MM MINSEREDER verrapt is largely influenced by the aging, regression analysis was carried out, then the most suitable regression function (R-square=0.4997) was as follows ;CBF index = log (CBF) = 4.59-0.0129Xage.Mean corrected CBF index in the normal control was 4.21<plus-minus>0.22 (N=21), and it's distribution showed normal distribution (Wilk-Shapiro's另一方面，精神分裂症组的测试是3.98 <plus-minus> 0.38（n =作为第三维，脑电图分析（FFT分析）是通过16ch的位置进行的。在EEG研究中，精神分裂症患者的显着变化是缓慢的频带功率（+1至+21％上升），淡入α活性的淡出，并且显着（p <0.05）β带活性的增加（P <0.05）。进行这三个维度定量研究，包括额外的较差研究（包括前叶功能障碍），也没有观察到。因此，我们未能重新确认这些假设。但是，无论使用这三个维度图，我们都可能能够将精神分裂症的病例与正常情况区分开。