Multi-axial Physical Brain Examination on Schizophrenia.

精神分裂症的多轴物理脑检查。

基本信息

批准号：
63480259
负责人：
OKAZAKI Yuji
金额：
$ 3.26万
依托单位：
Nagasaki University
依托单位国家：
日本
项目类别：
Grant-in-Aid for General Scientific Research (B)
财政年份：
1988
资助国家：
日本
起止时间：
1988 至 1990
项目状态：
已结题

项目摘要

Three dimensional physical examination study was carried out on schizophrenics diagnosed by DSM-III and normal volunteers as the control.As the first dimension, CT data were sampled from SIEMENS SOMATOM CR scanner on the condition of digital data. Some fresh schizophrenics have showed diffuse low dencity CT-value, however, this finding was transitional and it's CT-value has showed recovered to the normal range.In the comparison between two group, mean CT density of the schizophrenics (N=47, 34.3<plus-minus>2.67) were significantly (p<0.05) lower than that of the control (N=13, 35.64<plus-minus>1As the second dimension, in the rCBF measurement using 1231-IMP SPECT with arterial blood sampling method, mean schizophrenic whole brain CBF (N=21, 62.7<plus-minus>19.3ml/100g/min) showed decreased from that of the control (N=30, 56.5<plus-minus>17.6ml/100g/mTherefore CBF is largely influenced by the aging, regression analysis was carried out, then the most suitable regression function (R-square=0.4997) was as follows ;CBF index = log (CBF) = 4.59-0.0129Xage.Mean corrected CBF index in the normal control was 4.21<plus-minus>0.22 (N=21), and it's distribution showed normal distribution (Wilk-Shapiro's test). On the other hand, that of the schizophrenics group was 3.98<plus-minus>0.38 (N=As the third dimension, EEG power examination (FFT analysis) was carried out by 16ch location. In the EEG study, remarkable changes in the schizophrenic patients were increase in the slow frequency band power (+1 to+21%up), fade down alpha activity, and significantly (P<0.05) increase of beta band activity.Throughout these three dimensional quantitative studies, neither regionality (including frontal lobe dysfunction) nor laterality was observed. Thus, we failed to reconfirm these hypotheses.However using these three dimensional plots, we might be able to discriminate schizophrenic cases from the normal objectively.

以DSM-III诊断的精神分裂症患者和正常志愿者为对照进行三维体格检查研究。CT数据作为第一维，在数字数据条件下从SIEMENS SOMATOM CR扫描仪采集。一些新鲜的精神分裂症患者表现为弥漫性低密度CT值，但这种发现是过渡性的，其CT值已显示恢复至正常范围。两组比较，精神分裂症患者的平均CT密度(N=47, 34.3) <正负>2.67）显着（p<0.05）低于对照（N=13， 35.64±1作为第二个维度，在使用动脉血采样法的1231-IMP SPECT进行的rCBF测量中，平均精神分裂症全脑CBF（N=21，62.7±19.3ml/100g/min）显示与对照相比有所下降（N=30， 56.5±17.6ml/100g/m因此CBF受老化影响较大，进行回归分析，则最合适的回归函数（R平方=0.4997）如下：CBF指数=log（CBF） = 4.59-0.0129Xage。正常对照中的平均校正 CBF 指数为 4.21<正负>0.22 (N=21)，其分布呈正态分布(Wilk-Shapiro's检验)，而精神分裂症组为3.98±0.38(N=作为第三维，EEG功率检查(FFT)。分析）是通过16ch位置进行的。在脑电图研究中，精神分裂症患者的显着变化是慢频带功率增加（+1至+21%up）、α带活动减弱、β带活动显着（P<0.05）增加。通过这三项研究在维度定量研究中，既没有观察到区域性（包括额叶功能障碍），也没有观察到偏侧性。因此，我们未能再次证实这些假设。然而，使用这些三维图，我们也许能够客观地区分精神分裂症病例与正常病例。