Small radius artificial blood vessel with a high endothelial reorganization effect by static magnetic stray field from ferrite coating

铁氧体涂层静杂散场具有高内皮重组效应的小半径人造血管

• 批准号: 05454693
• 负责人: ABE Masanori
• 金额: $ 4.22万
• 依托单位: TOKYO INSTITUTE OF TECHNOLOGY
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for General Scientific Research (B)
• 财政年份: 1993
• 资助国家: 日本
• 起止时间: 1993 至 1995
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-05454693/
• 关键词: Artificial blood vessel; Ferrite coating; Endothelial reorganization; Ferrite plating; Brocompatibility; 生体適合成; 静磁場; フェライト; メッキ; 内皮細胞

Basic knowledges required for fabricating artificial blood vessel with ferrite coating on their inner wall were investigated ; the leakage flux from the ferrite coating is expected to enhance the endothelial reorganization, and, therefore, supress thrombi. Sheets of expanded polytetrafluoroethylene (EPTFE) membrane were exposed to an rf air plasma on which magnetite (Fe_3O_4) coating was successfully deposited by ferrite plating ; the rf plasma increases the wettability of the surface of the EPTFE.By exposing the surface of the EPTFE sheet which is dipped in an aqueous solution of H_3BO_3, the wettability was increased further more, and Fe_3O_4 coating of finer grains were successfully deposited. By in viva experiments on dogs revealed that the biocompatibility of the ferrite-coated EPTFE sheets are nearly equal to that of the uncoated sheets. To reveal the enhancement of the endothelial reorganization effect, further experiments are needed.

探讨了制作内壁铁氧体涂层人工血管所需的基础知识；铁氧体涂层的漏磁通预计会增强内皮重组，从而抑制血栓。将膨体聚四氟乙烯（EPTFE）膜片暴露于射频空气等离子体中，通过铁氧体电镀成功地在膜片上沉积磁铁矿（Fe_3O_4）涂层；射频等离子体提高了EPTFE表面的润湿性。通过将浸在H_3BO_3水溶液中的EPTFE片材表面暴露，润湿性进一步增加，成功沉积了更细晶粒的Fe_3O_4涂层。通过对狗进行体内实验表明，铁氧体涂层 EPTFE 片材的生物相容性几乎与未涂层片材相同。为了揭示内皮重组效应的增强，需要进一步的实验。

项目成果

Q.Zhang: "Magnetite Coating Prepared by Ferrite Plating on Expanded PTFE Membrane for Medical Use" J.Appl.Phys.(掲載予定). (1994)

Q.Zhang：“医用膨胀聚四氟乙烯膜上的铁氧体镀层制备”J.Appl.Phys（即将出版）。

M.Abe: "Magnetite coating prepared by ferrite plating on expanded polytetrafluoroethy lene membrane for medical use" J.Appl.Phys.75. 7171-7173 (1994)

M.Abe：“医用膨胀聚四氟乙烯膜上通过铁氧体电镀制备的磁铁矿涂层”J.Appl.Phys.75。

Q.ZHANG: "Magnetite Coting Prepared by Ferrite Plating on Expanded Polytetrafluorethylene Membrane for Medical Use" J.Appl.Phys. 75. 7171-7173 (1994)

张Q：“医疗用膨胀聚四氟乙烯膜上铁氧体电镀制备的磁铁矿涂层”J.Appl.Phys。