Diagnostic system of bone defect and scar tissue distribution in cleft lip and palate patients by using laser device

激光装置诊断唇腭裂患者骨缺损及疤痕组织分布的系统

基本信息

批准号：
04454516
负责人：
ISHIKAWA Hiroyuki
金额：
$ 3.71万
依托单位：
Hokkaido University
依托单位国家：
日本
项目类别：
Grant-in-Aid for General Scientific Research (B)
财政年份：
1992
资助国家：
日本
起止时间：
1992 至 1994
项目状态：
已结题

项目摘要

Many investigators have reported that surgical repair of palatal clefts inhibits maxillary growth, and produces a distortion of the dental arch and a retrusion of the mid-face in cleft palate patients. Especially, mucoperiosteal denudation of palatal bone and scar tissue following the surgery are the major factors of these growth problems. The information about the scar tissue distributions on palates is important to growth studies of cleft palates and useful for orthodontic diagnosis, treatment planning and prognosis. However, it is difficult to identify the scar tissue visually, and there is no reliable method to determine scar tissue areas. To solve the problem, the laser doppler flowmeter was applied to differentiate the scar tissue from normal palate tissue. And effects of the scar tissue distributions on dental arch form and maxillary growth were investigated in this study. The following results were obtained.1. By pressing larger palatine foramen, decrease in tissue blood flow was found on entire palatal surface in non-cleft subjects, but tissue blood flow was unchanged in the anterior portion of palates of cleft palate patients.2. Histological obseservations suggested that the laser doppler flowmetry was effective to identify the scar tissue produced on the raw surface, based on the difference in circulatory conditions between the scar tissue and normal tissue.3. The scar tissue distributions of cleft palate patients were divided into four types, and each type has a characteristic feature of a dental arch deformity.4. There was no evident correlation between the scar tissue distributions and the maxillary growth.

许多研究人员报告说，腭裂手术修复会抑制上颌骨生长，并导致腭裂患者牙弓变形和面中部后缩。尤其是手术后腭骨粘膜骨膜剥脱和疤痕组织是这些生长问题的主要因素。有关腭上疤痕组织分布的信息对于腭裂的生长研究很重要，并且有助于正畸诊断、治疗计划和预后。然而，肉眼识别疤痕组织比较困难，也没有可靠的方法来确定疤痕组织的面积。为了解决这个问题，应用激光多普勒流量计来区分疤痕组织和正常腭组织。本研究探讨了疤痕组织分布对牙弓形态和上颌骨生长的影响。得到如下结果： 1．按压较大的腭孔，非腭裂患者整个腭面组织血流量减少，而腭裂患者腭前部组织血流量无变化。 2．组织学观察表明，激光多普勒血流仪根据疤痕组织与正常组织之间循环条件的差异，可以有效地识别原始表面上产生的疤痕组织。3．将腭裂患者的疤痕组织分布分为四种类型，每种类型均具有牙弓畸形的特征。 4．疤痕组织分布与上颌骨生长之间没有明显的相关性。