Unraveling the differential role of myeloid cells in the regulation of ANCA-induced glomerulonephritis

揭示骨髓细胞在 ANCA 诱导的肾小球肾炎调节中的不同作用

• 批准号: 404613165
• 负责人: Privatdozent Dr. Adrian Schreiber
• 金额: --
• 依托单位: Experimental and Clinical Research Center (ECRC)
• 依托单位国家: 德国
• 项目类别: Research Grants
• 财政年份: 2018
• 资助国家: 德国
• 起止时间: 2017-12-31 至 2022-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/404613165?language=en
• 关键词: Unraveling; differential; role; myeloid; cells

The aim of the research proposal is the detailed analysis of the pathogenic contribution of different myeloid subspecies and the identification of a regulatory network between myeloid cells and T-cells in ANCA-induced glomerulonephritis. We and others have shown that both neutrophils and monocytes are activated in vitro by ANCA. However, their contribution to the induction of an ANCA-glomerulonephritis and the specific role of different myeloid subpopulations is not understood. Therefore, we will analyze the contribution of different myeloid subpopulations to ANCA-glomerulonephritis by specific modulation of these subpopulations in two different ANCA-animal models. Furthermore, we will characterize a regulatory network between myeloid cells and adaptive T-cell immunity in ANCA-glomerulonephritis. In addition, we aim to establish a urinary myeloid and T-cell flow-cytometry signature in patients with ANCA-glomerulonephritis. In summary our studies will result in a better understanding of the role of myeloid cells in the pathogenesis of ANCA-glomerulonephritis and their role in the regulation of T-cell immunity.

研究建议的目的是详细分析了不同髓样亚种的致病作用，以及髓样细胞和ANCA诱导的肾小球肾炎中髓样细胞和T细胞之间的调节网络的鉴定。我们和其他人表明，嗜中性粒细胞和单核细胞在体外都被ANCA激活。但是，他们对诱导ANCA-胶质素肾炎的贡献以及不同髓样亚群的具体作用尚不清楚。因此，我们将通过在两个不同的ANCA-Animal模型中对这些亚群的特定调节来分析不同髓样亚群对ANCA-胶质酮的贡献。此外，我们将表征髓样细胞之间的调节网络和ANCA-氯洛尼肾炎中的适应性T细胞免疫。此外，我们旨在在ANCA-氯洛尼肾炎患者中建立尿髓样和T细胞流通术特征。总而言之，我们的研究将更好地理解髓样细胞在ANCA-氯洛尼肾炎发病机理中的作用及其在调节T细胞免疫中的作用。