Multiunit Recording and Processing System and Its Application

多单元记录处理系统及其应用

• 批准号: 63870006
• 负责人: TANJI Jun
• 金额: $ 4.42万
• 依托单位: TOHOKU UNIVERSITY
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Developmental Scientific Research
• 财政年份: 1988
• 资助国家: 日本
• 起止时间: 1988 至 1989
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-63870006/
• 关键词: Multiunit; Microelectrode; Micromachining; Cerebral Cortex; マイクロパタ-ンニング; マイクロパタ-ニング

A new type of multiple-unit recording electrodes and a system to record from the multiple electrodes are developed. the electrodes were designed to incorporate 4 to 32 channel recording system built in a compound electrode-carrying probe. The probe was made of the center Elgiloy-alloy metal needle and low melting point grass material covering the metal. The Elgiloy was etched to form a thin tip. The metal shaft was covered with a thin layer of grass, on which electrode pattern and connecting fine leads were drawn. A special version of the micropatterning technique was employed. The key point was to form a fine micro pattern on the metal needle. An automated patterning system was made to draw a precise, three dimensional micropattern. This was realized by a microcomputer program. Ultrathin layers of Au-Cr was placed on the surface of the grass, utilizing the vacuum-vaporization method. The three dimensional lithography was applied with usage of the patterning system and an automated, ultraviolet beam-exposion system. The electrode leads were fed to multiplexer integrated circuit and then were connected to preamplifiers. Recording experiments were carried out in rats and monkeys to test the validity of the recording system. Interrelations of multiple unit activities and their relation to the motor output were examined.

开发了一种新型的多单元记录电极和一个从多个电极记录的系统。电极旨在结合建在复合电极携带探针中的4至32通道记录系统。该探头是由中心Elgiloy合金金属针和覆盖金属的低熔点草材料制成的。将Elgiloy蚀刻为形成薄尖端。金属轴上覆盖着一层薄薄的草，在上面绘制了电极图案和连接细导线。采用了微观图案的特殊版本。关键点是在金属针上形成细小的微型图案。建立了一个自动模式系统，以绘制精确的三维微图案。这是由微型计算机程序实现的。利用真空蒸发法，将Au-Cr的超薄层放在草的表面上。使用图案系统和自动化的紫外线曝光系统应用了三维光刻。将电极引线喂入多路复用器积分电路，然后连接到前置放大器。记录实验是在大鼠和猴子中进行的，以测试记录系统的有效性。检查了多个单位活动及其与电动机输出的关系。

项目成果

丹治順: "認識し行動する脳(伊藤正男・佐伯・胖編)" 東京大学出版会, 91-111 (1988)

Jun Tanji：“识别和行动的大脑（由Masao Ito、Saeki和Akira编辑）”东京大学出版社，91-111（1988）

Inase,M.Mushiake,H.,Shima,K,Aya,K.and Tanji,J.: "Activity of digital area neurons of the primary somato sensory cortex in relation to sensonally triggered and self-initiated digital movements of monkeys." Neurosci.Res.7. 219-234 (1989)

Inase,M.Mushiake,H.,Shima,K,Aya,K.和 Tanji,J.：“初级躯体感觉皮层的数字区域神经元的活动与猴子的感觉触发和自我启动的数字运动有关。”

Sato,T.and Tanji,J: "Digit muscle responses evoked from multiple intracorticail foci in monkey precentral motor cortex" J.Neuro physiol. 62. 959-970 (1989)

Sato,T. 和 Tanji,J：“猴子前中央运动皮层中多个皮质内病灶诱发的数字肌肉反应”J.Neuro Physol。

丹治順: "新生理科学大系10巻" 医学書院, 72-83 (1988)

Jun Tanji：《新生理科学第10卷》医学书院，72-83（1988）

江刺正善,庄司習一: "マイクロプロ-ブの立体的微細加工" 医用電子と生体工学. 27. (1989)

Masayoshi Esashi、Shuichi Shoji：“微探针的三维微加工”《医疗电子与生物工程》27。（1989）