Correlation between functional properties and histochemical classifications of cerebtral motor areas of primates.

灵长类动物大脑运动区功能特性与组织化学分类之间的相关性。

基本信息

批准号：
02044016
负责人：
TANJI Jun
金额：
$ 16.64万
依托单位：
Department of Physiology, Tohoku University School of Medicine
依托单位国家：
日本
项目类别：
Grant-in-Aid for international Scientific Research
财政年份：
1990
资助国家：
日本
起止时间：
1990 至 1992
项目状态：
已结题

项目摘要

The primary aim of this project is to combine neurophysiological study by a research group in Took University with histological and immunohistochemical study by a research group in Syracuse, N.Y., in order to study functional and morphological organization of motor area in the cerebral cortex. The international research collaboration between these two laboratories have been extensively achieved, resulting in extremely successful research works. The research findings are so numerous that it is possible to describe only major ones as follows.(1) Histological identification of cortical cingulate motor areas, and physiological analysis of cellular activity. Three separate areas in the cingulate cortex were identified as forelimb motor areas. Cellular activity in each area is found to be region-specific in relation to trained motor tasks.(2) Delineation of a new cortical motor area in the mesial frontal lobe. lmmediately rostral to the supplementary motor area, a new motor related cortical … More area was defined on the basis of physiological and histological findings.(3) Functional plasticity of the supplementary motor area (SMA). SMA activity was found to undergo plastic changes, depending on how motor tasks were performed. Plastic changes after lesioning of primary motor cortex were also found.(4) ldentification of projection systems from basal ganglia to SMA. Histochemical tracer techniques with fluorescent dyes and enzymes were applied to identify unequivocally the projection system from the basal ganglia through the thalamus to SMA, yielding successful results.(5) Neuronal mechanisms for sequential performance of motor tasks. Neuronal activity responsible for sequencing of motor behavior was found in the basal ganglia and cerebellum, each with regard to different aspects of motor control.(6) lmmunohistochemical study of cortico-subcortical circuits utilizing HSV-1 viruses. Coirtico-thalamo-pallidal and cortico-thalamo-cerebellar neural circuits were identified by the use of different strains of HSV-1 viruses.(7) Microinjection of chemical neurotransmitters into premotor areas. The inhibitory neurotransmitter, GABA, and its agonist, muscimol, were applied to reveal functional subdivisions of premotor areas of primates. Less

该项目的主要目的是将大学研究小组与纽约州锡拉丘兹的一项研究小组的组织学和免疫组织化学研究相结合，以研究大脑皮层运动区运动区域的功能和形态组织。这两个实验室之间的国际研究合作已得到广泛的实现，从而实现了非常成功的研究工作。研究结果是如此之多，以至于只能描述主要的发现。（1）皮质扣带回运动区域的组织学鉴定以及细胞活性的物理分析。扣带回皮层中的三个独立区域被确定为前肢运动区域。发现每个区域的细胞活性与训练有素的运动任务相关。（2）介绍中额叶中新的皮质运动区域。 lmsostral到补充运动区域，这是一种新的与运动相关的皮层……根据物理和组织学发现，定义了更多的区域。（3）补充运动区域（SMA）的功能可塑性。发现SMA活动会发生塑料变化，具体取决于如何执行运动任务。还发现了原发性运动皮层病变后的塑性变化。（4）从基底神经节到SMA的投影系统的降低。使用荧光染料和酶的组织化学示踪剂技术，以明确地识别从基底神经节通过丘脑到SMA的投影系统，从而获得成功的结果。（5）神经元机制，以进行运动任务的顺序性能。在基底神经节和小脑中发现了导致运动行为测序的神经元活性，每个神经元在运动控制的不同方面。（6）使用HSV-1病毒对皮质毛的肌肉皮质回路的Lmmuno组化研究。通过使用不同菌株的HSV-1病毒菌株，可以鉴定出高表皮 - 甲状腺 - 甲状腺 - 甲状腺 - 甲状腺甲状腺 - 甲状腺 - 甲状腺脑脑神经通路。应用抑制性神经递质GABA及其激动剂Muscimol，用于揭示主要前部门的功能细分。较少的