Prevention of Alzheimer disease by oral bacteria having plasmalogenphospholipid

通过含有缩醛磷脂的口腔细菌预防阿尔茨海默病

• 批准号: 23658066
• 负责人: KAMIO Yoshiyuki
• 金额: $ 2.5万
• 依托单位: Tohoku University (2012)Yamagata University (2011)
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Challenging Exploratory Research
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-23658066/
• 关键词: プラズマローゲン; 認知症予防; 口腔内細菌; γセクレターゼ; βアミロイド; プラズマローゲンリン脂質; ヒト認知症予防; Selenomonas 属細菌; 酵母ミクロソ－ム画分; ベータアミロイド; Selenomonas sputigena; ヒト口腔内細菌; γ-セクレターゼ; 酵母ミクロソーム画分

We found plasmalogen phospholipids (Pls), which are known to preventeAlzheimer disease (AD), in a human oral bacteria, Selenomonas sputigena. It has been known that Pls decrease in brain of AD patient. γ-Secretase(γS) is known to cleave amyloid precursor protein toproduce amyloid β peptides (Aβ) that is deposited in the brain of Alzheimer disease. Here we examined a relationship between phospholipid composition and production of γ-secretase in human brain, by in vitro assay system using Saccharomyces cerevisiae, which was established by Futai et al. The followings are evident, (1) Aβ-production is enhanced by the addition of phosphatidyl choline (PC), and (2) addition of phosphatidyl ethanolamine Pls (EPPls) to in vitro assay system prevented γS activity. Thus we concluded that the reduction of EPPls in the phospholipid fraction in human brain enhances the γS activity and causes Aβ-production and/or accumulation in AD patient. This is a first report in theworld.

我们发现，已知的磷脂磷脂（PL），已知质子蛋白蛋白质蛋白质淀粉样蛋白β肽（Aβ）的淀粉样蛋白蛋白质蛋白质蛋白质蛋白质蛋白质蛋白质蛋白质的脑含量降低。 ，通过使用SacCharomyces的体外测定，Futaie et and shece是明显的。人脑中的EPPL增强了γs，并引起Aβ的生产和/或AD患者。

项目成果

Membrane-Damaging Activity Against Various Phospholipid Liposomes by γ-hemolysin, Staphylococcal Two-Component Pore-Forming Cytolysin

针对各种磷脂脂质体的膜损伤活性

• DOI: 10.1299/jbse.7.292
• 发表时间: 2012
• 期刊: Journal of Biomechanical Science and Engineering
• 作者: Noriko Tomita;Yoshiyuki Kamio and Makoto Ohta
• 通讯作者: Yoshiyuki Kamio and Makoto Ohta

偏性嫌気性細菌Selenomonas ruminantiumの表層膜安定機構―細胞壁結合型カダベリンの分子機能及びその合成・制御系

专性厌氧细菌反刍硒单胞菌表面膜稳定机制——细胞壁结合尸胺的分子功能及其合成与控制系统

• 发表时间: 2012
• 期刊: ビタミン
• 作者: 児島征司;神尾好是
• 通讯作者: 神尾好是

Molecular basis for the maintenance of cell envelope integrity in Selenomonas ruminantium which possesses cadaverine as an essential constituent of the peptidoglycan andregulation of the biosynthesis of cadaverine

具有尸胺作为肽聚糖基本成分的反刍月孢单胞菌维持细胞包膜完整性的分子基础以及尸胺生物合成的调节

• 发表时间: 2013
• 作者: Noriko Tomita;Kazuyo Abe;Jun Kaneko;Yoshiyuki Kamio;Makoto Ohta;Y. Kamio
• 通讯作者: Y. Kamio

細菌細胞壁結合ポリアミンの膜安定化機構と合成制御（シンポジウム）

细菌细胞壁结合多胺的膜稳定机制和合成控制（研讨会）

• 发表时间: 2013
• 作者: Noriko Tomita;Kazuyo Abe;Jun Kaneko;Yoshiyuki Kamio;Makoto Ohta;Y. Kamio;神尾好是;Yoshiyuki Kamio;神尾好是
• 通讯作者: 神尾好是

偏性嫌気性細菌Selenomonas ruminantiumの表層膜安定化機構-細胞壁結合型カダベリンの分子機能並びにその合成・制御系-

专性厌氧菌反刍硒单胞菌表面膜稳定机制-细胞壁结合尸胺的分子功能及其合成与控制系统-

• 发表时间: 2012
• 期刊: ビタミン
• 作者: 児島征司;神尾好是
• 通讯作者: 神尾好是