Study of oral biofilm associated with bacterial surface amyloid

细菌表面淀粉样蛋白相关的口腔生物膜研究

• 批准号: 24659821
• 负责人: SENPUKU Hidenobu
• 金额: $ 2.33万
• 依托单位: National Institute of Infectious Diseases
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Challenging Exploratory Research
• 财政年份: 2012
• 资助国家: 日本
• 起止时间: 2012-04-01 至 2014-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-24659821/
• 关键词: アミロイド; S. mutans; バイオフィルム; 遺伝子; コンゴーレッド; 異常蛋白質; SMU482; SMU574; S. gordonii; 病原性; S, gordonii; コンゴ―レッド; 異常タンパク質

Amyloid is an insoluble fiber protein involving one specific structure. It was clealy that this amyloid was associated with the biofilm formation in gram positive bacteria.Streptococcus mutans is possessing the amyloid implicated in the biofilm formation.This study showed a posssibility that SMU482 and SMU574 associated with amyloid formation in S. mutans genes. SMU482 related with the biofilm formation but SMU574 did not related with that. Therefore, it was clearly that the amyloid formation is not necessarily concerned with biofilm formation.

淀粉样蛋白是一种涉及一种特定结构的不溶性纤维蛋白。克服这种淀粉样蛋白与革兰氏阳性细菌中的生物膜形成有关。链球菌突变体具有与生物膜形成有关的淀粉样蛋白。这项研究表明，SMU482和SMU574与S. Mutans Genes中的淀粉样蛋白形成相关的可能性。 SMU482与生物膜形成有关，但SMU574与此无关。因此，显然，淀粉样蛋白形成不一定与生物膜形成有关。

项目成果

Effect of Porphyromonas gingivalis outer membrane vesicles on gingipain-mediated detachment of cultured oral epithelial cells and immune responses

• DOI: 10.1016/j.micinf.2013.10.005
• 发表时间: 2014-01-01
• 期刊: MICROBES AND INFECTION
• 影响因子: 5.8
• 作者: Nakao, Ryoma;Takashiba, Shogo;Senpuku, Hidenobu
• 通讯作者: Senpuku, Hidenobu

Dynamic changes in the initial colonization of Actinomyces naeslundii and Streptococcus gordonii using a new animal model.

• DOI: 10.7883/yoken.66.11
• 发表时间: 2013
• 期刊: Japanese journal of infectious diseases
• 影响因子: 2.2
• 作者: Xi Zhang;H. Senpuku

E2f1-deficient NOD/SCID mice have dry mouth due to a change of acinar/duct structure and the down-regulation of AQP5 in the salivary gland

• DOI: 10.1007/s00424-012-1183-y
• 发表时间: 2013-02-01
• 期刊: PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY
• 影响因子: 4.5
• 作者: Satoh, Keitaro;Narita, Takanori;Sugiya, Hiroshi
• 通讯作者: Sugiya, Hiroshi

Effects of salivary protein flow and indigenous microorganisms on initial colonization of Candida albicans in an in vivo mode

唾液蛋白流和本土微生物对体内白色念珠菌初始定植的影响

• 发表时间: 2012
• 期刊: BMC Or al Health
• 作者: Norihiko Kanaguchi;Naoki Natisawa;Tatsuro Ito;Yosuke Kinoshita;Yoko Kusumoto;Osamu Shinozuka and Hidenobu Senpuku
• 通讯作者: Osamu Shinozuka and Hidenobu Senpuku

Roles of outer vesicles of Porphyromonas gingivalis for a mucosalimmune response

牙龈卟啉单胞菌外囊泡对粘膜免疫反应的作用

• 发表时间: 2012
• 作者: T Senpuku;T Fujimaru;T Arakawa;T Ishizaki;R Hayman;Y Kono;S Sekine;H Suzuki;anf T Ikemi;H Senpuku and R Nakao
• 通讯作者: H Senpuku and R Nakao