A novel pathogenesis of rheumatoid arthritis due to dysregulated super-enhancer in CD4-positive T cells

CD4 阳性 T 细胞中超级增强子失调导致类风湿性关节炎的新发病机制

• 批准号: 19K08925
• 负责人: YAMAGATA KAORU
• 金额: $ 2.75万
• 依托单位: University of Occupational and Environmental Health, Japan
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2019
• 资助国家: 日本
• 起止时间: 2019-04-01 至 2022-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-19K08925/
• 关键词: 関節リウマチ; CD4陽性T細胞; スーパーエンハンサー; UBASH3A; BACH2; eRNA; ChIP; ubash3a; SNP; MED1; 炎症; 関節破壊

项目成果

軟骨組織修復方法

软骨组织修复方法

• 发表时间: 2019

Emerging role of epigenetic dysregulation of ubash3a in the pathogenesis of rheumatoid arthritis (RA)

ubash3a 表观遗传失调在类风湿性关节炎 (RA) 发病机制中的新作用

• 发表时间: 2020
• 作者: Kaoru Yamagata;Shingo Nakayamada;Tong Zhang;Gulzhan Trimova;Phuong Anh Nguyen;Fumi Uemura;Ippei Miyagawa;Shigeru Iwata;Yoshiya Tanaka
• 通讯作者: Yoshiya Tanaka

Involvement of lncRNA IL21-AS1 in interleukin-2 and T follicular regulatory cell activation in systemic lupus erythematosus.

• DOI: 10.1186/s13075-021-02682-w
• 发表时间: 2021-12-11
• 期刊: Arthritis research & therapy
• 影响因子: 4.9
• 作者: Hao H;Nakayamada S;Ohkubo N;Yamagata K;Zhang M;Shan Y;Iwata S;Zhang T;Tanaka Y
• 通讯作者: Tanaka Y

Massive in silico studies specified UBASH3A as a candidate pathogenic factor that is down-regulated in CD4+T cells of patients with rheumatoid arthritis (RA)

大量计算机研究将 UBASH3A 指定为类风湿性关节炎 (RA) 患者 CD4 T 细胞下调的候选致病因子

• 发表时间: 2019
• 作者: Kaoru Yamagata;Shingo Nakayamada;Ippei Miyagawa;Fumi Uemura;Shigeru Iwata;Yoshiya Tanaka
• 通讯作者: Yoshiya Tanaka

T helper cells expressing fractalkine receptor and bearing T follicular helper 1-like cell functions in patients with IgG4-related disease.

IgG4 相关疾病患者中表达 fractalkine 受体并具有滤泡辅助 T 1 样细胞功能的 T 辅助细胞。

• DOI: 10.1093/rheumatology/keab935
• 发表时间: 2021
• 期刊: Rheumatology (Oxford)
• 作者: Inoue Y;Nakayamada S;Kubo S;Yamagata K;Sonomoto K;Iwata S;Miyazaki Y;Tanaka Y.
• 通讯作者: Tanaka Y.