Appetitive 50-kHz ultrasonic vocalizations in rats and their biopsychological analysis in sender and recipient

大鼠食欲 50 kHz 超声波发声及其发射器和接收器的生物心理分析

• 批准号: 326649283
• 负责人: Professor Dr. Rainer K.W. Schwarting
• 金额: --
• 依托单位: Abteilung Verhaltensneurowissenschaft
• 依托单位国家: 德国
• 项目类别: Research Grants
• 财政年份: 2017
• 资助国家: 德国
• 起止时间: 2016-12-31 至 2021-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/326649283?language=en
• 关键词: Appetitive; 50; kHz; ultrasonic; vocalizations

Rodents, like rats and mice, which serve most often as subjects in animal research, vocalize using so-called ultrasonic vocalizations. These vocalizations may indicate their emotional and motivational status and induce signal-specific changes in brain and behavior of their conspecific recipients. In this project, the appetitive effect of rat 50-kHz calls will be investigated, which is functionally related to the neurotransmitter dopamine. By combining specific behavioral tests (especially playback of 50-kHz calls) and immunohistochemical, electrophysiological, and psychopharmacological techniques, critical mechanisms will be investigated, which may underlie the appetitive quality of these calls acutely and the habituation to them after repeated exposure. Here, the nucleus accumbens will receive specific attention, since this structure plays an important role in these calls and in the neurobiology of motivated behavior. The expected results will be important in terms of basic research but also for the application of rat ultrasonic vocalizations in models of human psychiatric diseases.

啮齿动物，如大鼠和小鼠，最常作为动物研究的对象，使用所谓的超声波发声来发声。这些发声可能表明他们的情绪和动机状态，并引起大脑和同种接受者行为的信号特异性变化。在这个项目中，将研究大鼠 50-kHz 叫声的食欲效应，这在功能上与神经递质多巴胺有关。通过结合特定的行为测试（特别是 50 kHz 呼叫的回放）和免疫组织化学、电生理学和精神药理学技术，将研究关键机制，这可能是这些呼叫的强烈食欲质量以及反复接触后对它们的习惯的基础。在这里，伏隔核将受到特别关注，因为这种结构在这些呼叫和动机行为的神经生物学中发挥着重要作用。预期的结果不仅对于基础研究很重要，而且对于大鼠超声发声在人类精神疾病模型中的应用也很重要。