Analysis of the performance-enhancing effects of hippocampal lesions in rat serial reaction time task

海马损伤对大鼠系列反应时任务的性能增强作用分析

基本信息

批准号：
232681559
负责人：
Professor Dr. Rainer K.W. Schwarting
金额：
--
依托单位：
Abteilung Verhaltensneurowissenschaft
依托单位国家：
德国
项目类别：
Research Grants
财政年份：
2013
资助国家：
德国
起止时间：
2012-12-31 至 2017-12-31
项目状态：
已结题

来源：
https://gepris.dfg.de/gepris/projekt/232681559?language=en
关键词：
Analysis performance enhancing effects hippocampal

项目摘要

Sequential learning is a basic form of knowledge acquisition, namely implicit or procedural learning, which is tested in humans and primates using serial reaction time tasks. In Parkinson patients and by use of brain imaging techniques, it could be shown that fronto-striatal and dopaminergic processed play a central role in sequential behavior. We have developped a rat version with high face validity of the serial reaction time task to study neural mechanisms including manipulative approaches, and our translational studies to validate the test showed that dopamine lesions can impair sequential behavior, especially during learning. More recently, we studied the hippocampus, which is thought to play a role for explicit and spatial learning and memory. Surprisingly, we repeatedly found that lesions of the hippocampus substantially enhanced performance in our task, which supports the hypothesis that simultaneous information provided by basal ganglia and hippocampus to frontal cortical sites can compete with each other during sequential learning and that hippocampal information may not play a crucial role during sequential learning. Here, we want to address some yet unresolved questions regarding this lesion effect: a) Is the performance-enhancing effect specific for sequential learning or does it improve instrumental learning which is required in our task, b) are lesions of the intermediate hippocampus, which provided important inputs to frontal cortical sites, sufficient for the effect?, and c) are the effects specific for task acquisition and can they also be induced by reversible pharmacological blockade of the hippocampus?

顺序学习是知识获取的一种基本形式，即隐式或程序学习，它在人类和灵长类动物中使用串行反应时间任务进行了测试。在帕金森氏症患者和使用脑成像技术中，可以证明额叶纹状体和多巴胺能加工在顺序行为中起着核心作用。我们已经开发了一个具有串行反应时间任务的高面有效性的大鼠版本，以研究包括操纵方法在内的神经机制，我们的翻译研究以验证测试，表明多巴胺病变会损害顺序行为，尤其是在学习过程中。最近，我们研究了海马，这被认为在显式和空间学习和记忆中起着作用。令人惊讶的是，我们反复发现，海马的病变大大提高了我们的任务的性能，这支持了以下假设：基底神经节和海马提供给额叶皮质位点提供的同时信息可以在顺序学习过程中彼此竞争，并且海马信息可能无法播放一项海马信息。顺序学习中的关键作用。在这里，我们想解决有关这种病变效应的一些尚未解决的问题：a）是针对顺序学习的性能增强效果，或者它改善了工具性学习，这是我们任务中需要的，b）是中间海马的病变，这是中间海马的病变，提供了对额叶皮质位点的重要输入，足以效果？和c）是否对任务采集的效果也可以受到海马的可逆药理学阻滞而诱导的效果吗？