Ultrafast functional magnetic resonance imaging with MR-encephalography

磁共振脑成像超快功能磁共振成像

基本信息

批准号：
290467483
负责人：
Professor Dr. Jürgen Hennig
金额：
--
依托单位：
Arbeitsbereich Medizinphysik
依托单位国家：
德国
项目类别：
Reinhart Koselleck Projects
财政年份：
2016
资助国家：
德国
起止时间：
2015-12-31 至 2020-12-31
项目状态：
已结题

来源：
https://gepris.dfg.de/gepris/projekt/290467483?language=en
关键词：
Ultrafast functional magnetic resonance imaging

项目摘要

The proposal is aimed to the development of new ultrafast methods and technologies for functional magnetic resonance imaging (fMRI) for direct observation of spatiotemporal neuronal processing ¿ in other words to observe the brain at work. The goal will be to achieve a new level of performance significantly beyond the currently known experimental approaches. In order to achieve this goal, new methods and technologies will have to be developed on all levels of the measurement: - the re-building of a highly integrated RF-coil array with 95 channels as a basis of the methodological development.- new measurement sequences will have to be developed in order to get beyond the limitations of current approaches. Measurement will include prospective and/or retrospective motion correction as well as realtime field monitoring to stabilize data reconstruction. - a framework of iterative reconstruction algorithms including corrections for dynamic changes (motion, field changes) as well as neuroanatomical constraints will have to be developed.- fast image reconstruction for realtime fMRI will be developed and implemented. With the newly developed methods we will perform application studies with a focus on - investigation of the physiological mechanism of resting state networks (RSNs) especially at high frequencies of up to 5 Hz, imvestigation of high frequency RSNs in volunteers and patients.- development and application of realtime feedback fMRI.- examination of spatiotemporal dynamics of interictal epileptic discharges (IEDs).- examination of dynamic processing in complex, real-life tasks.

该提案的目的是开发用于功能磁共振成像（fMRI）的新的超快方法和技术，用于直接观察空间颞神经元处理»换句话说，以观察工作中的大脑。目标是超出当前已知的实验方法，达到新的绩效水平。为了实现这一目标，必须在所有级别的测量层面上开发新的方法和技术： - 重建具有95个通道的高度集成的RF线圈阵列，作为方法论开发的基础。-必须开发新的测量序列，以超出当前方法的限制。测量将包括前瞻性和/或回顾性运动校正以及实时野外监控，以稳定数据重建。 - 必须开发迭代重建算法的框架，包括动态变化（运动，场更改）以及神经解剖约束的校正。-将开发和实施实时fMRI的快速图像重建。借助新开发的方法，我们将进行申请研究，重点是研究静止状态网络（RSN）的物理机制（RSN），尤其是在高达5 Hz的高频，优化志愿者和患者中高频RSN的优化。现实生活任务。