Ultrafast functional magnetic resonance imaging with MR-encephalography

磁共振脑成像超快功能磁共振成像

基本信息

批准号：
290467483
负责人：
Professor Dr. Jürgen Hennig
金额：
--
依托单位：
Arbeitsbereich Medizinphysik
依托单位国家：
德国
项目类别：
Reinhart Koselleck Projects
财政年份：
2016
资助国家：
德国
起止时间：
2015-12-31 至 2020-12-31
项目状态：
已结题

来源：
https://gepris.dfg.de/gepris/projekt/290467483?language=en
关键词：
Ultrafast functional magnetic resonance imaging

项目摘要

The proposal is aimed to the development of new ultrafast methods and technologies for functional magnetic resonance imaging (fMRI) for direct observation of spatiotemporal neuronal processing ¿ in other words to observe the brain at work. The goal will be to achieve a new level of performance significantly beyond the currently known experimental approaches. In order to achieve this goal, new methods and technologies will have to be developed on all levels of the measurement: - the re-building of a highly integrated RF-coil array with 95 channels as a basis of the methodological development.- new measurement sequences will have to be developed in order to get beyond the limitations of current approaches. Measurement will include prospective and/or retrospective motion correction as well as realtime field monitoring to stabilize data reconstruction. - a framework of iterative reconstruction algorithms including corrections for dynamic changes (motion, field changes) as well as neuroanatomical constraints will have to be developed.- fast image reconstruction for realtime fMRI will be developed and implemented. With the newly developed methods we will perform application studies with a focus on - investigation of the physiological mechanism of resting state networks (RSNs) especially at high frequencies of up to 5 Hz, imvestigation of high frequency RSNs in volunteers and patients.- development and application of realtime feedback fMRI.- examination of spatiotemporal dynamics of interictal epileptic discharges (IEDs).- examination of dynamic processing in complex, real-life tasks.

该提案旨在开发用于功能磁共振成像（fMRI）的新超快方法和技术，以直接观察时空神经处理 ¿换句话说，我们的目标是实现显着超出当前已知实验方法的新水平的性能，必须在各个层面上开发新的方法和技术。测量： - 重建具有 95 个通道的高度集成射频线圈阵列，作为方法开发的基础。 - 必须开发新的测量序列，以超越当前方法的局限性。测量将包括前瞻性的测量。和/或回顾性运动校正以及实时- 必须开发一个迭代重建算法框架，包括动态变化（运动、场变化）以及神经解剖学约束的校正 - 将开发和实施用于实时功能磁共振成像的快速图像重建。我们将针对新开发的方法进行应用研究，重点是 - 研究静息态网络 (RSN) 的生理机制，特别是在高达 5 Hz 的高频下，研究志愿者和患者的高频 RSN。 - 开发和应用的实时反馈功能磁共振成像。-检查发作间期癫痫放电（IED）的时空动态。-检查复杂的现实生活任务中的动态处理。