Enantioselective Synthesis of Photodynamic Rubellin Anthraquinone Dimers

光动力红柏林蒽醌二聚体的对映选择性合成

• 批准号: 270889223
• 负责人: Dr. Vincent Eschenbrenner-Lux
• 金额: --
• 依托单位: Department of Chemistry
• 依托单位国家: 德国
• 项目类别: Research Fellowships
• 财政年份: 2014
• 资助国家: 德国
• 起止时间: 2013-12-31 至 2016-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/270889223?language=en
• 关键词: Enantioselective; Synthesis; Photodynamic; Rubellin; Anthraquinone

The project covers the targeted syntheses of interesting dimeric anthraquinone natural products, the rubellins. The strategies developed for their formation are inspired from the informations obtained from their biosynthesis in the organisms they have been extracted from. The rubellins are a family of anthraquinone dimers that were isolated from a series of plant-parasitic fungi, and show potential antimicrobial and anticancer properties. The planned synthesis of this compound family includes the development of an atroposelective cross-coupling followed by an axial-to-point transferring dearomative photocyclization as key steps of the transformation. Subsequently, the synthesized compounds will be subjected to phenotypic screening under the influence of light to evaluate their photodynamic activity as chemical probes in biological systems. These compounds are potential chemical probes for the development of new photodynamic therapies, in the frame of prostate, ovary, and pancreas cancer research.

该项目涵盖了有趣的二聚体arthraquinone天然产品Rubellins的靶向合成。从其从其中提取的生物中获得的生物合成所获得的信息，从其从中提取的生物合成获得的策略启发了它们的启发。 Rubellins是一个从一系列植物性真菌中分离出来的蒽醌二聚体的家族，并显示出潜在的抗菌和抗癌特性。该复合家族的计划合成包括开发一个骨质选择性交叉耦合，然后是轴向转移的轴向转移，作为转化的关键步骤。随后，合成化合物将在光的影响下进行表型筛查，以评估其光动力活性作为生物系统中的化学探针。这些化合物是在前列腺，卵巢和胰腺癌研究框架内开发新的光动力疗法的潜在化学探针。