Great Lakes Center for Fresh Waters and Human Health

五大湖淡水和人类健康中心

• 批准号: 2418066
• 负责人: Gregory Dick
• 金额: $ 385.65万
• 依托单位: Regents of the University of Michigan - Ann Arbor
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2024
• 资助国家: 美国
• 起止时间: 2024-04-15 至 2029-03-31
• 项目状态: 未结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=2418066&HistoricalAwards=false
• 关键词: Great; Lakes; Center; Fresh; Waters

The Great Lakes Center for Fresh Waters and Human Health is a consortium of over 10 universities and agencies working in the Great Lakes region and directed by the University of Michigan and University of Toledo. The Center is a five year effort to further our understanding of the critical risk that climate change, and resulting cyanobacterial harmful algal blooms (cHABs), pose to freshwater ecosystems and human health. Increased precipitation, more powerful storm events, and warming waters all encourage the proliferation of cHABs, which now occur in all five Great Lakes. The Center is organized around several overarching themes. The first is to resolve how climate change influences the occurrence of cHABs and the transport of the toxins they produce. The second is to understand toxin production and how toxins impact health, through both airborne and waterborne exposure. The third is to develop new technologies for enhanced monitoring and forecasting. In collaboration with agency and community partners the team will integrate findings into state-of-the-art forecasts and other data products that reach a wide stakeholder audience. A Community Engagement Core (CEC) will connect Center science to relevant communities, promoting co-design of research and communication of research outcomes to stakeholders. The team will leverage the Center’s research enterprise to recruit and train a diverse next generation of scientists in the field of oceans and human health, including support for graduate students and postdocs. The Center will advance inclusivity in all facets of research and engagement. Together, these research, engagement, and training activities will advance progress toward the stated goals of understanding and translating climate change effects on cHAB events and their threats to human health in the Great Lakes region. The Center is jointly supported by NSF’s Division of Ocean Sciences and by the National Institute for Environmental Health Sciences (NIEHS).The Center’s research is organized around four distinct but highly integrated projects. Project 1 seeks to determine how a changing climate influences the proliferation and toxin production of cHAB taxa. This project will use a multipronged field-lab experimental approach to test the hypothesis that climate-driven episodic events (e.g., storms) affect several classes of cyanotoxins (microcystins, anatoxins, saxitoxins, and anabaenopeptins), taste and odor compounds, and phycosphere interactions. Project 2 seeks to reveal the diversity, spatial and temporal distribution, and bioactivity of known and undiscovered toxins and other secondary metabolites. This project will use a combination of approaches (including metagenomics, transcriptomics, and metabolomics) to characterize the diversity of emerging toxins and bioactive compounds currently invisible to methods used in routine water quality analysis. Project 3 will study toxin release from cHAB cells, aerosolization, and transport to test the hypothesis that climate change will increase human exposure to cHAB toxins through ingestion and inhalation. A combined measurement and modeling approach will be used to evaluate the impact of climate-change driven stressors on the distribution of dissolved and particulate toxins in both water bodies and aerosols generated from cHABs, enabling predictions of toxin exposure under a changing climate. Project 4 will assess the effects of aerosolized toxins on human health with a special focus on populations that are vulnerable due to pre-existing conditions, such as asthma. Project 4 will test the overall hypothesis that exposure to aerosolized cyanotoxins induces significant inflammation in the airway epithelium and that individuals with asthma are particularly susceptible to cHAB aerosols. Combined with the results of the other three projects, this work will enable assessment of human health risks of cHAB toxins under current conditions and future climate scenarios. In summary, the Great Lakes Center for Fresh Waters and Human Health aims to understand and communicate the risks of cHABs in the face of climate change through collaborative research, engagement efforts, and training initiatives.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

五大湖淡水与人类健康中心是由十多所在五大湖地区工作的大学和机构组成的联盟，由密歇根大学和托莱多大学领导，该中心历经五年努力，旨在加深我们对五大湖地区淡水和人类健康的了解。气候变化以及由此产生的蓝藻有害藻华 (CHAB) 对淡水生态系统和人类健康构成的重大风险，降雨量增加、风暴事件更加强烈以及海水变暖都会促进 CHAB 的扩散，该中心围绕几个首要主题开展工作，首先是解决气候变化如何影响 cHAB 的发生及其产生的毒素的运输，其次是了解毒素的产生以及毒素如何产生。第三是通过与机构和社区合作伙伴合作开发新技术来加强监测和预测，该团队将把研究结果整合到最先进的预测和其他数据产品中。宽社区参与核心（CEC）将中心科学与相关社区联系起来，促进研究的共同设计以及向利益相关者传达研究成果。该团队将利用中心的研究企业来招募和培训多元化的下一代科学家。该中心将在海洋和人类健康领域促进研究生和博士后的包容性，这些研究、参与和培训活动将共同推动实现既定的理解和参与目标。翻译气候变化该中心由 NSF 海洋科学部和国家环境健康科学研究所 (NIEHS) 共同支持。该中心的研究围绕四个不同但高度相关的领域进行。项目 1 旨在确定气候变化如何影响 cHAB 类群的增殖和毒素产生。该项目将使用多管齐下的现场实验室实验方法来检验气候驱动的偶发事件的假设。 （例如风暴）会影响几类蓝藻毒素（微囊藻毒素、鱼腥藻毒素、石房蛤毒素和鱼腥肽）、味道和气味化合物以及藻圈相互作用。项目 2 旨在揭示已知和未发现的毒素的多样性、空间和时间分布以及生物活性。该项目将结合使用多种方法（包括宏基因组学、转录组学和代谢组学）来研究。表征目前常规水质分析中使用的方法无法发现的新兴毒素和生物活性化合物的多样性。项目 3 将研究 cHAB 细胞的毒素释放、雾化和运输，以检验气候变化将增加人类通过摄入摄入 cHAB 毒素的假设。将采用综合测量和建模方法来评估气候变化驱动的压力源对水体中溶解和颗粒毒素以及产生的气溶胶的分布的影响。 cHAB 能够预测气候变化下的毒素暴露情况，项目 4 将评估雾化毒素对人类健康的影响，特别关注因哮喘等已有疾病而易受影响的人群。假设接触雾化的蓝藻毒素会引起气道上皮的严重炎症，并且哮喘患者特别容易受到 cHAB 气溶胶的影响，结合其他三个项目的结果，这项工作。将能够评估当前条件和未来气候情景下的 cHAB 毒素的人类健康风险。 总之，五大湖淡水和人类健康中心旨在通过合作研究了解和交流面临气候变化的 cHAB 风险。该努力奖反映了 NSF 的法定使命，并通过使用基金会的智力价值和更广泛的影响审查标准进行评估，被认为值得支持。