RUI: Reactive Intermediates and Unusual Molecules from Phenanthrene-based Precursors

RUI：来自菲基前体的反应中间体和异常分子

• 批准号: 2400007
• 负责人: Dasan Thamattoor
• 金额: $ 38万
• 依托单位: Colby College
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2024
• 资助国家: 美国
• 起止时间: 2024-07-01 至 2027-06-30
• 项目状态: 未结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=2400007&HistoricalAwards=false
• 关键词: RUI; Reactive; Intermediates; Unusual; Molecules

With support from the Chemical Structure, Dynamics & Mechanism-B (CSDM-B) Program of the Chemistry Division and the Established Program to Stimulate Competitive Research (EPSCoR), Professor Dasan Thamattoor of the Department of Chemistry at Colby College and his team of undergraduate students are undertaking a study of reactive intermediates and unusual molecules generated from phenanthrene-based precursors. The structure and reactivity of the targeted chemical species, which are of academic as well as practical interest, will be investigated experimentally and by modern computational methods. In addition, several initiatives to create meaningful research experiences for undergraduates, foster international research collaborations with student participation, and promote high-quality science education for K-12 students in area schools will be pursued.Singlet vinylcarbenes play a key role in cyclopropene isomerizations and other important synthetic transformations. Yet little is known about their chemistry. Likewise, experimental data on the kinetics and structure of cyclopropylidene, the smallest carbocyclic carbene, and its derivatives, are quite sparse. In this proposal, cyclopropanated phenanthrene precursors will be used to investigate the structure and reactivities of vinylcarbenes and cyclopropylidenes. Furthermore, innovative approaches to using cyclobutanated phenanthrenes as sources of ketenes and allenes will be pursued. A broad range of experimental methods such as steady state photolysis, EPR spectroscopy, matrix isolation spectroscopy, and time-resolved laser flash photolysis as well as modern computational tools will be used in these investigations. The ready synthesis, stability, ease of handling, and versatility of the proposed precursors make these projects ideal for involving undergraduate students. The proposed work, which integrates synthetic, mechanistic, and computational organic chemistry, is designed to provide students with a comprehensive research experience, pique their curiosity, and engage them as partners in the discovery process.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

在化学结构，动力学和机制-B（CSDM-B）化学部门的支持和刺激竞争研究的既定计划（EPSCOR）的支持下，科尔比学院化学系的达桑·塔玛托教授及其本科生的团队正在研究反应性中间体和不惯性分子的基于近代的基于近代的基于近代的基于近代的基于近代的精良的研究。具有学术性和实际利益的目标化学物种的结构和反应性将通过实验和现代计算方法进行研究。此外，还将追求几项为大学生创造有意义的研究经验，促进国际研究合作的计划，并促进针对地区学校中K-12学生的高质量科学教育。然而，他们的化学知之甚少。同样，关于环丙基丙烯，最小的碳环甲苯及其衍生物的动力学和结构的实验数据非常稀疏。在此提案中，环丙丙者的稳态前体将用于研究乙烯基碳酸盐和环丙基烯的结构和反应性。此外，将追求使用环形抗形态的这一方法作为酮和艾伦的来源的创新方法。这些研究将使用广泛的实验方法，例如稳态光解，EPR光谱，基质分离光谱和时间分辨激光闪光光解以及现代计算工具。拟议的前体的现成合成，稳定性，易于处理和多功能性使这些项目非常适合让本科生参与。拟议的工作结合了合成，机械和计算有机化学，旨在为学生提供全面的研究经验，激烈的好奇心，并将其作为伙伴参与发现过程。该奖项反映了NSF的法定任务，并被认为是通过基金会的智力功能和广泛影响的评估来评估CRETERIA的评估。