RUI: Syntheses, Structures, and Reactions of Strained Cyclic Allenes

RUI：应变环烯的合成、结构和反应

• 批准号: 1012914
• 负责人: Dasan Thamattoor
• 金额: $ 26.5万
• 依托单位: Colby College
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-09-15 至 2013-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1012914&HistoricalAwards=false
• 关键词: RUI; Syntheses; Structures; Reactions; Strained

This award from the Chemical Structure, Dynamics and Mechanism Program of the Division of Chemistry supports Professor Dasan M. Thamattoor of the Chemistry Department at Colby College in Waterville, ME in his exploration of the following topics: 1) Generation of strained allene compounds via novel decomposition of spiropentanes; 2) Synthesis of derivatives of 1,2 cycloheptadiene and 1,2 cyclooctadiene that are stable enough to form crystals suitable for x-ray diffraction, and 3) Development of pyrolysis methods for converting cycloalkenylcarbenes to strained cyclic allenes. Computational studies using Density Functional Theory (DFT) would be done in parallel with the experiments to provide insight into product stabilities and reaction pathways. The proposed work, which integrates elements of synthetic, mechanistic, and computational organic chemistry, is designed to provide undergraduates with a wholesome research experience, and enable them to make original contributions to scientific knowledge. Among the most important broader impacts of this research, as mentioned above, is the mentoring of undergraduate researchers and training them as future scientists in a predominantly undergraduate institution. A number of ideas for melding research and education, based on approaches that have already met with success, will be implemented. This is exemplified, for instance, by the incorporation of research-like projects and new pedagogical experiments in the introductory organic chemistry laboratory course. The proposal also seeks to continue Prof. Thamattoor's highly successful program that provides research opportunities to high school students over the summer months. Women, minorities, and students from disadvantaged backgrounds will also be recruited to participate in summer research activities. In addition, there will be new initiative that forges partnerships with elementary school teachers to specifically strengthen the science curriculum in the K-3 level. Finally, it is expected that a number of important fundamental chemical reaction pathways will be elucidated.

该奖项由化学系化学结构、动力学和机理项目颁发，支持缅因州沃特维尔科尔比学院化学系 Dasan M. Thamattoor 教授对以下主题的探索：1) 通过新颖的方法生成应变丙二烯化合物螺戊烷的分解； 2) 合成 1,2 环庚二烯和 1,2 环辛二烯衍生物，这些衍生物足够稳定以形成适合 X 射线衍射的晶体，以及 3) 开发将环烯基卡宾转化为应变环状丙二烯的热解方法。使用密度泛函理论 (DFT) 的计算研究将与实验并行进行，以深入了解产品稳定性和反应途径。拟议的工作整合了合成、机械和计算有机化学的元素，旨在为本科生提供有益的研究经验，并使他们能够对科学知识做出原创贡献。如上所述，这项研究最重要的广泛影响之一是在以本科为主的机构中对本科研究人员进行指导并将他们培训为未来的科学家。基于已经取得成功的方法，许多融合研究和教育的想法将得到实施。例如，在介绍性有机化学实验室课程中纳入类似研究的项目和新的教学实验就证明了这一点。该提案还旨在继续 Thamattoor 教授非常成功的项目，该项目在夏季为高中生提供研究机会。妇女、少数族裔和来自弱势群体的学生也将被招募参加夏季研究活动。此外，还将采取新举措与小学教师建立伙伴关系，专门加强 K-3 级别的科学课程。最后，预计许多重要的基本化学反应途径将得到阐明。