STTR Phase I: Innovative Expandable Dental Sealer

STTR 第一阶段：创新的可扩展牙科封闭剂

• 批准号: 2321456
• 负责人: Fatereh Samadi
• 金额: $ 27.49万
• 依托单位: Afsartech Inc.
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-10-01 至 2024-09-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=2321456&HistoricalAwards=false
• 关键词: STTR; Phase; Innovative; Expandable; Dental

The broader impact/commercial potential of this Small Business Technology Transfer (STTR) Phase I project is in developing a novel dental sealer technology for root canal treatments for endodontists and general dentists. The complex and inaccessible nature of the root canal system causes 65% of root canal fillings to fail. Expandable dental sealers used during root canal treatments provide an effective solution by filling the gaps in the canal space by preventing leakage, enabling clinicians to perform the procedure with greater ease and accuracy. This project’s commercial impact includes an addressable market of 22.3 million root canal treatments annually. The proposed innovation supports enhanced patient safety, reduced time at the dentists'/endodontists' office and decreased costs for patients, reduced risk of infection and retreatment, and advanced capabilities of clinicians through training.This Small Business Technology Transfer (STTR) Phase I project will characterize the expansion and other properties of the patented elastomeric polyurethane sealer (EPS). The project will begin by generating a functionalized and optimized formula of the EPS using additive ingredients. The team will perform in vitro testing to evaluate the material’s physicochemical properties. Finally, the study will establish the in vivo histocompatibility of EPS using animal models and check its cytotoxicity, a key hurdle that must be overcome before clinical evaluation and Food and Drug Administration (FDA) registration. These studies will facilitate the development of an entirely new type of dental sealer.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

该小型企业技术转移（STTR）I期项目的更广泛的影响/商业潜力在于开发一种新型的牙科密封剂技术，用于用于牙髓医生和普通牙医的根管处理。根管系统的复杂且无法接近的性质导致65％的根管填充物失败。在根管处理中使用的可扩展牙科密封剂通过防止泄漏来填补运河空间中的间隙，从而使临床医生能够更加轻松和准确地执行该程序，从而提供了有效的解决方案。该项目的商业影响包括每年2230万根管道处理的可寻址市场。提出的创新支持增强的患者安全，减少牙医/牙髓医生办公室的时间，以及患者的成本增加，降低感染和恢复的风险以及通过培训通过培训来实现临床医生的先进能力。这一小型企业技术转移（STTR）阶段I阶段项目将表征受过恐惧的弹性弹性弹性弹性弹性弹性弹性弹性弹性弹性弹性弹性弹性和其他特性。该项目将首先使用其他inredients生成EPS的功能化和优化公式。该团队将进行体外测试以评估材料的物理特性。最后，该研究将使用动物模型来建立EPS的体内组织相容性，并检查其细胞毒性，这是必须成为临床评估和食品药物管理（FDA）注册之前的关键障碍。这些研究将支持开发一种全新的牙科密封剂。该奖项反映了NSF的法定任务，并通过使用基金会的知识分子优点和更广泛的影响评估标准来评估，被认为是珍贵的支持。