Equipment: MRI: Track 1 Acquisition of a 600 MHz NMR with Cryoprobe for the Greater Rocky Mountain Region

设备： MRI：轨道 1 为大落基山脉地区采购带有冷冻探针的 600 MHz NMR

• 批准号: 2320158
• 负责人: Brian Michel
• 金额: $ 139.77万
• 依托单位: University of Denver
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-09-01 至 2026-08-31
• 项目状态: 未结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=2320158&HistoricalAwards=false
• 关键词: Equipment; MRI; Track; Acquisition; 600

An award is made to the University of Denver to acquire a state-of-the-art 600 MHz Nuclear Magnetic Resonance (NMR) spectrometer with a Cryoprobe and a cooled SampleCase. This instrument will support researchers at the University of Denver and across the greater Rocky Mountain region, enabling new research ranging from understanding biomolecular interactions to characterizing functional tools in complex biological systems. This project will support modernization of curricular activities in undergraduate (Organic lab sequence, Instrumental Analysis, and Frontiers in Chemistry) and graduate courses (Organic Spectroscopy and Biophysical Methods), greatly increasing the number of students exposed modern 2D and multinuclear NMR experiments. High-school, undergraduate, graduate, and postdoctoral researchers will benefit from training on state-of-the-art equipment. This includes students in the SHINE@DU program, which provides paid 8-week summer internships to local junior and senior high-school students largely from groups underrepresented in the sciences. This project will benefit the citizen science Foldit game, which will continue to improve via validation of solved structures. Responsible stewardship and conservation of finite helium resources will continue through helium recovery and recycling at the University of Denver.The new instrument will enable biomolecular and chemical research owing to increased sensitivity, resolution, transceiver capability, and access that is not currently possible at the University of Denver and is severely limited in the region. This NMR will enable biomolecular researchers to (1) understand how nucleic acids interact with proteins to inhibit aggregation, (2) investigate the mechanism of how synthetic protein mimics modulate aberrant protein-protein interactions, and (3) discover and characterize novel metallophores. Chemical biology and chemical researchers will use the new NMR spectrometer to: (1) elucidate the structures of complex polyheterocycles, (2) characterize and investigate organometallic complexes as tools for probing biological systems, and (3) identify and analyze end-groups of functional linear polymers. A number of regional users, including researchers at primarily undergraduate institutions and area start-up companies, will have remote and in-person access to the new NMR.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

向丹佛大学颁发了奖励，以获得具有冷冻探针和冷却的抽样酶的最先进的600 MHz核磁共振（NMR）光谱仪。该工具将支持丹佛大学和大落基山地区的研究人员，从而实现了从了解生物分子相互作用到表征复杂生物系统中功能工具的新研究。该项目将支持本科课程活动的现代化（有机实验室序列，工具分析和化学领域）和研究生课程（有机光谱和生物物理方法），从而大大增加了暴露于现代2D和多核NMR实验的学生人数。高中，本科，研究生和博士后研究人员将受益于最先进的设备培训。这包括Shine@du计划中的学生，该计划为当地的初中和高中生提供了为期8周的暑期实习，这在很大程度上是从科学界人数不足的小组中提供的。该项目将使公民科学折叠游戏受益，该游戏将通过验证解决的结构来继续改善。负责任的管理和保存有限的氦资源将通过丹佛的氦气恢复和回收来持续。由于敏感性，分辨率，收发器能力的提高以及目前在丹佛大学无法获得的访问，该新工具将实现生物分子和化学研究，并在该地区受到严重限制。该NMR将使生物分子研究人员能够（1）了解核酸如何与蛋白质相互作用以抑制聚集，（2）研究合成蛋白模仿如何调节异常蛋白质蛋白相互作用的机制，以及（3）发现和表征新型的金属酚。化学生物学和化学研究人员将使用新的NMR光谱仪来：（1）阐明复杂多重地体时期的结构，（2）将有机金属络合物表征和研究作为探测生物系统的工具，（3）识别和分析功能线性聚合物的最终组。许多区域用户，包括主要是本科机构和地区初创公司的研究人员，将对新NMR进行遥远而亲自访问。该奖项反映了NSF的法定任务，并被认为是值得通过基金会的知识分子优点和更广泛的审查标准通过评估来进行评估的。