I-Corps: Enhancing Sensory Processing via Noninvasive Neuromodulation

I-Corps：通过无创神经调节增强感觉处理

• 批准号: 2232149
• 负责人: Qi Wang
• 金额: $ 5万
• 依托单位: Columbia University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-08-15 至 2024-07-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=2232149&HistoricalAwards=false
• 关键词: Corps; Enhancing; Sensory; Processing; via

The broader impact/commercial potential of this I-Corps project is the development of technology that accurately perceives details of tactile, auditory, and visual stimuli required for completing the tasks necessary for daily life and independent living. Impaired sensory processing may cause misperceptions and miscommunication that can be frustrating, debilitating, and dangerous. This technology rapidly modulates sensory processing and could provide an immediate benefit across many potential use cases. By restoring clear sensory processing, this technology seeks to facilitate a return to socializing, exercise, hobbies, and employment for many individuals who have withdrawn from those activities due to chronic sensory issues. An enhancement of sensory processing may improve the ability to communicate easily, ambulate safely, and handle objects with dexterity.This I-Corps project is based on the development of a method of rapidly enhancing the accuracy and detail of sensory information processed in the brain via a noninvasive neuromodulation technique. In both animal and human studies, enhanced sensory processing translated to increased sensory acuity as evidenced by improved performance on sensory tasks. This technology includes wearable neural stimulation patches that could treat a variety of clinical causes of impaired sensory processing. This patches cause tonic activation of the locus coeruleus-norepinephrine (LC-NE) system in the brain and have resulted in a rapid enhancement of thalamic sensory processing. This NE-enhanced sensory processing state increased the perceptual sensitivity of awake animals performing sensory tasks. The vagus nerve can be stimulated noninvasively in humans by delivering electric current transcutaneously, providing an effective and safe method of neuromodulation. This novel bioelectronic method of using continuous tonic VNS provides sensory enhancement on-demand.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

该 I-Corps 项目更广泛的影响/商业潜力是开发能够准确感知完成日常生活和独立生活所需任务所需的触觉、听觉和视觉刺激细节的技术。感觉处理受损可能会导致误解和沟通不畅，从而令人沮丧、虚弱和危险。 该技术可以快速调节感官处理，并可以在许多潜在用例中提供直接的好处。通过恢复清晰的感官处理，该技术旨在帮助许多因慢性感官问题而退出这些活动的人恢复社交、锻炼、爱好和就业。感觉处理的增强可以提高轻松沟通、安全行走和灵活处理物体的能力。该 I-Corps 项目基于开发一种快速增强大脑中处理的感觉信息的准确性和细节的方法一种无创神经调节技术。在动物和人类研究中，增强的感觉处理转化为感觉敏锐度的提高，这可以通过感觉任务表现的改善来证明。该技术包括可穿戴神经刺激贴片，可以治疗感觉处理受损的各种临床原因。该贴片会导致大脑中蓝斑-去甲肾上腺素 (LC-NE) 系统的强直激活，并导致丘脑感觉处理的快速增强。这种 NE 增强的感觉处理状态增加了清醒动物执行感觉任务的感知灵敏度。通过经皮传递电流，可以无创地刺激人体迷走神经，提供一种有效且安全的神经调节方法。这种使用连续强直 VNS 的新颖生物电子方法可按需增强感官。该奖项反映了 NSF 的法定使命，并通过使用基金会的智力价值和更广泛的影响审查标准进行评估，被认为值得支持。