New Anion Binders Based on Aromatic Linear and Cyclic Aromatic Oligoamides

基于芳香族线性和环状芳香族低酰胺的新型阴离子粘合剂

• 批准号: 2304878
• 负责人: Bing Gong
• 金额: $ 55万
• 依托单位: SUNY at Buffalo
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-12-15 至 2026-11-30
• 项目状态: 未结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=2304878&HistoricalAwards=false
• 关键词: New; Anion; Binders; Based; Aromatic

With the support of the Macromolecular, Supramolecular and Nanochemistry Program in the Division of Chemistry, Professor Bing Gong of the State University of New York at Buffalo will be studying designer molecules with cyclic scaffolds known as macrocycles and how they interact with anions. This research aims to further understanding of how macrocycle design can be finely tuned to build in anion specificity and to establish new ways to bind particular anions, especially for those that are important for energy and the environment. The team will also be looking at how these macrocycles can move anions through different barriers such as cell membranes or non-polar organic solutions, which could be useful in many different fields. This project will integrate molecular design with experimental studies and provide research training opportunities for undergraduate and graduate students, including students from underrepresented groups. The research results will be publicized broadly in the scientific community and incorporated into undergraduate and graduate teaching.The macrocycles being targeted herein have a constrained aromatic oligoamide backbone that enforces the convergent placement of multiple amide NH and phenyl CH groups. These NH and CH groups define an electropositive binding cavity that is highly pre-organized for binding anions. Because of their hydrogen-bonding capabilities and differences in preference for anions, the macrocycles are expected to exhibit versatile binding capabilities for anions with varying properties. The macrocycles will assist in transporting anions across cell membranes or bulk non-polar organic solvents. The efficiency and selectivity of anion transport will be assessed using established fluorescence assays including those based on vesicles (liposomes) or those using U-shaped tubes. This research team will (1) optimize and scale up the synthesis of the anion-binding macrocycles, (2) conduct systematic anion binding studies to quantify the binding affinities of the macrocycles with different anions in various solvents, and (3) examine anion transport across lipid bilayers or non-polar organic solvents to determine the efficiencies and selectivity of transporting homologous series anions, such as halides and oxoanions.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

在化学系中的大分子，超分子和纳米化学计划的支持下，纽约州立大学的Bing Gong教授将研究具有循环支架的设计师分子，称为循环支架，称为巨型型巨型细胞及其与阴离子相互作用。这项研究旨在进一步理解如何对大环设计进行精心调整以建立在阴离子特异性中，并建立新的方法来绑定特定的阴离子，尤其是对于那些对能量和环境很重要的阴离子。该团队还将研究这些大环如何通过不同的屏障（例如细胞膜或非极性有机溶液）移动阴离子，这在许多不同的领域都可能很有用。该项目将将分子设计与实验研究相结合，并为本科生和研究生（包括代表性不足的学生）提供研究培训机会。该研究结果将在科学界广泛公开，并将其纳入本科和研究生教学中。此处的宏观细胞具有约束的芳族寡酰胺骨架骨架，可实施多个酰胺NH和苯基CH组的收敛放置。这些NH和CH组定义了一个高度预先组织的电阳性结合腔，用于结合阴离子。由于它们具有氢键的能力和对阴离子的偏好差异，大环有望表现出具有变化性质的阴离子的多功能结合能力。大环将有助于跨细胞膜或散装非极性有机溶剂运输阴离子。阴离子转运的效率和选择性将使用已建立的荧光测定法评估，包括基于囊泡（脂质体）或使用U形管的荧光测定。 This research team will (1) optimize and scale up the synthesis of the anion-binding macrocycles, (2) conduct systematic anion binding studies to quantify the binding affinities of the macrocycles with different anions in various solvents, and (3) examine anion transport across lipid bilayers or non-polar organic solvents to determine the efficiencies and selectivity of transporting homologous series anions, such as halides该奖项反映了NSF的法定任务，并被认为是值得通过基金会的知识分子优点和更广泛的影响评估标准的评估来支持的。