A National Research Facility for EPR Spectroscopy, 2022-2027

国家 EPR 光谱研究设施，2022-2027

• 批准号: EP/W014521/1
• 负责人: David Collison
• 金额: $ 630.88万
• 依托单位: University of Manchester
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2022
• 资助国家: 英国
• 起止时间: 2022 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=EP%2FW014521%2F1
• 关键词: National; Research; Facility; EPR; Spectroscopy

Electrons are fundamental to the composition of all materials, determining the structure of molecular bonds and the stability and properties of compounds. The study of the electronic distribution in molecules therefore provides a direct window into understanding molecular structure, function and bonding. Electrons possess a fundamental property called "spin", which, pictured classically causes the electron to behave as a bar-magnet when placed in a magnetic field. In many materials all electrons are present in pairs, with the spin on the two electrons being equal and opposite. However, in many important materials there are unpaired electrons: such materials are called paramagnets. Paramagnets are ubiquitous across physical, biological and materials sciences, for example in free-radicals, metal ions, active sites in biological systems, or defects in solids, and these unpaired electrons are critical in dictating the electronic, magnetic and (bio)chemical behaviour of such materials. Unpaired electrons can be intrinsic to the material or extrinsic, induced by, for example, chemical doping or labelling, or by electrochemical or optical excitation.The most powerful method to study paramagnetic materials is Electron Paramagnetic Resonance (EPR) spectroscopy, also known as Electron Spin Resonance (ESR), part of the magnetic resonance range of techniques that also includes Magnetic Resonance Imaging (MRI) and Nuclear Magnetic Resonance (NMR). EPR directly probes the environment of the unpaired electrons, yielding information on the chemical environment in which the electron is present. State-of-the-art EPR requires substantial instrumentation, including continuous wave and pulsed techniques (differing in how microwaves are applied, and how the signal is detected), and variable magnetic field and temperature regimes, giving access to different information content on the paramagnet. A National Research Facility (NRF) for EPR gives a cost-effective method for wide access to infrastructure, expertise and training to the UK academic community. The NRF will support researchers in their projects from first enquiry, where assistance can be provided to design, plan and cost experiments into grant applications, through to training via hands-on experience and training courses, support to perform experiments, and advice and expertise to aid data analysis, modelling and interpretation.

电子是所有材料组成的基础，决定着分子键的结构以及化合物的稳定性和性质。因此，对分子中电子分布的研究为理解分子结构、功能和键合提供了直接的窗口。电子具有一种称为“自旋”的基本特性，按照经典的描述，当电子置于磁场中时，这种特性会导致电子表现得像条形磁铁。在许多材料中，所有电子都是成对存在的，两个电子的自旋大小相等且方向相反。然而，在许多重要材料中都存在不成对的电子：此类材料称为顺磁体。顺磁体在物理、生物和材料科学中无处不在，例如在自由基、金属离子、生物系统中的活性位点或固体缺陷中，这些不成对的电子在决定电子、磁性和（生物）化学行为方面至关重要此类材料。不成对的电子可以是材料固有的，也可以是外在的，例如通过化学掺杂或标记，或者通过电化学或光学激发诱导。研究顺磁性材料的最强大的方法是电子顺磁共振 (EPR) 光谱，也称为电子自旋共振 (ESR) 是磁共振技术范围的一部分，还包括磁共振成像 (MRI) 和核磁共振 (NMR)。 EPR 直接探测不成对电子的环境，产生有关电子所在化学环境的信息。最先进的 EPR 需要大量仪器，包括连续波和脉冲技术（不同之处在于如何应用微波以及如何检测信号）以及可变磁场和温度状态，从而可以获取有关顺磁体。 EPR 国家研究机构 (NRF) 为英国学术界广泛获取基础设施、专业知识和培训提供了一种经济有效的方法。 NRF 将为研究人员的项目提供支持，从最初的询问，到资助申请中的设计、规划和成本实验的协助，再到通过实践经验和培训课程进行的培训，支持进行实验，以及为资助申请提供建议和专业知识。帮助数据分析、建模和解释。

项目成果

Erythrosin B as a New Photoswitchable Spin Label for Light-Induced Pulsed EPR Dipolar Spectroscopy

赤藓红 B 作为光诱导脉冲 EPR 偶极光谱的新型光开关自旋标记

• DOI: http://dx.10.3390/molecules27217526
• 发表时间: 2022
• 期刊: Molecules
• 影响因子: 4.6
• 作者: Bertran A

Advances in Biomolecular EPR

生物分子 EPR 的进展

• DOI: http://dx.10.1016/bs.mie.2022.02.012
• 发表时间: 2022
• 作者: Bertran A

Decorating polymer beads with 1014 inorganic-organic [2]rotaxanes as shown by spin counting.

自旋计数显示，用 1014 个无机-有机 [2] 轮烷装饰聚合物珠。

• DOI: http://dx.10.1038/s42004-022-00689-1
• 发表时间: 2022
• 期刊: Communications chemistry
• 影响因子: 5.9
• 作者: Asthana D

Hexanuclear Ln 6 L 6 Complex Formation by Using an Unsymmetric Ligand

使用不对称配体形成六核 Ln 6 L 6 络合物

• DOI: http://dx.10.1002/chem.202302497
• 发表时间: 2023
• 期刊: Chemistry - A European Journal
• 作者: Bell D

Direct Comparison between Förster Resonance Energy Transfer and Light-Induced Triplet-Triplet Electron Resonance Spectroscopy.

福斯特共振能量转移与光诱导三重态-三重态电子共振光谱之间的直接比较。

• DOI: http://dx.10.1021/jacs.3c04685
• 发表时间: 2023
• 期刊: Journal of the American Chemical Society
• 影响因子: 15
• 作者: Bertran A