Collaborative Research: Electrocatalytic Synthesis of Heterocycles from Biomass-Derived Furanics via Immobilized 1st-Row Transition Metal Catalysts

合作研究：通过固定化第一行过渡金属催化剂从生物质衍生的呋喃中电催化合成杂环化合物

• 批准号: 2245564
• 负责人: De-en Jiang
• 金额: $ 15万
• 依托单位: Vanderbilt University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-11-01 至 2024-12-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=2245564&HistoricalAwards=false
• 关键词: Collaborative; Research; Electrocatalytic; Synthesis; Heterocycles

With the support of the Chemical Catalysis program in the Division of Chemistry, Yujie Sun from the University of Cincinnati and De-en Jiang from the University of California-Riverside are studying the electrocatalytic conversion of biomass-derived compounds to value-added compounds. Biomass is a promising sustainable raw material and biomass valorization continues to attract increasing attention. However, most existing methods for the synthesis of value-added chemical building blocks from biomass are inefficient and not cost-effective compared to those employed in the petrochemical industry. Following the principles of green chemistry, Drs. Sun and Jiang will design and develop kinetically viable and low-cost electrocatalysts for the upgrading of biomass-derived chemicals to value-enhanced heterocyclic compounds. The synergy between the experimental and computational efforts of the two principal investigators is notable and offers potential for improved understanding of the various electrocatalytic processes under study. Dr. Sun has been actively developing a new course in Green Chemistry to offer undergraduates a broad background in sustainable chemical approaches and methods. Dr. Jiang has been developing a Freshman Discovery Seminar entitled “Frontiers in Chemical Research” to chemistry-oriented freshmen. Dr. Jiang is also working closely with the Riverside STEM Academy 15, a Riverside Unified School with a focus on STEM. Both research groups are actively involved in a variety of other outreach programs, such as UC Community Day Open House and UC-Chem Summer Camp at the Cincinnati Museum Center.With the support of the Chemical Catalysis program in the Division of Chemistry, Yujie Sun from the University of Cincinnati and Professor De-en Jiang from the University of California Riverside are developing 1st-row transition metal-based electrocatalysts to synthetically upgrade biomass-derived compounds to value-added heterocyclic compounds. Chemical synthesis from biomass has attracted increasing interest because of its abundant, sustainable, and carbon-neutral nature. Due to the existence of multiple functional groups in biomass-derived intermediate compounds, selective transformations are crucial for the successful upgrading of biomass to targeted chemical systems. Taking advantages of both homogeneous and heterogeneous catalytic strategies, Drs. Sun and Jiang will investigate 1st-row transition metal-based and coordinatively-unsaturated electrocatalysts immobilized on electrodes for the selective transformation of biomass-derived furan-based edicts into heterocyclic compounds of interest. Fundamental knowledge of the electrocatalytic mechanisms involved is expected to evolve out of these studies given the tight integration of theory/computation and experiment in the approach.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

在化学催化计划的支持下，辛辛那提大学的Yujie Sun和加利福尼亚大学河畔大学的De-en Jiang正在研究生物质衍生化合物的电催化转化为增值化合物。生物量是一种承诺的可持续原材料，生物质价值继续吸引越来越多的关注。但是，与在石化工业中使用的大多数现有的合成增值化学构建块的方法无效，并且不具有成本效益。遵循绿色化学原理，博士。 Sun和Jiang将设计和开发可行的和低成本的电催化剂，以升级生物质衍生的化学物质至值增强的杂环化合物。两个主要研究者的实验和计算工作之间的协同作用是值得注意的，并为改善研究所研究的各种电催化过程提供了潜力。 Sun博士一直在积极开发一门新的绿色化学课程，以提供可持续化学方法和方法的广泛背景。 Jiang博士一直在为面向化学的新生开发一个名为“化学研究的边界”的新生发现研讨会。 Jiang博士还与Riverside STEM Academy 15密切合作，这是一所河滨统一学校，重点是STEM。 Both research groups are actively involved in a variety of other outreach programs, such as UC Community Day Open House and UC-Chem Summer Camp at the Cincinnati Museum Center.With the support of the Chemical Catalysis program in the Division of Chemistry, Yujie Sun from the University of Cincinnati and Professor De-en Jiang from the University of California Riverside are developing 1st-row transition metal-based Electrocatalysts to synthetically升级生物质衍生化合物到增值杂环化合物。由于其丰富，可持续和碳中性的性质，生物质的化学合成引起了人们的兴趣越来越大。由于生物质衍生的中间化合物中存在多个官能团，因此选择性转化对于成功升级生物质至靶向化学系统至关重要。具有均质和异质催化策略的优势，Drs。 Sun和Jiang将研究固定在电极上的第一行过渡金属和协调不饱和的电催化剂，以选择将基于生物量的Furan Ects选择性转化为感兴趣的杂环化合物。鉴于理论/计算和实验在方法中的紧密整合，对涉及的电催化机制的基本知识有望从这些研究中发展出来。该奖项反映了NSF的法定任务，并被认为是通过基金会的智力优点和更广泛影响的审查标准来评估通过评估来获得的支持。

项目成果

Bromonium-Mediated Electrochemical Synthesis of 3-Pyridinol from Biomass-Derived Furfurylamine

• DOI: 10.1021/acs.jpcc.3c02245
• 发表时间: 2023-05
• 期刊: The Journal of Physical Chemistry C
• 作者: Kaili Yan;H. Kwon;Morgan Huddleston;D. Jiang;Yujie Sun