Collaborative Research: An integrative approach to understanding variation in patterns of aging in primates

合作研究：了解灵长类动物衰老模式变化的综合方法

• 批准号: 2235564
• 负责人: Amy Lu
• 金额: $ 41.79万
• 依托单位: SUNY at Stony Brook
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-04-01 至 2026-03-31
• 项目状态: 未结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=2235564&HistoricalAwards=false
• 关键词: Collaborative; Research; integrative; approach; understanding

Human lifespan has doubled in the last century, and this has been linked to an increase in age-associated disease. These diseases stem from the natural age-associated deterioration of bodily function but it is unclear how deterioration across systems – for example, bone loss and decreased immune system function – are related. It also remains to be determined whether patterns of aging and age-associated disease in humans are further impacted by a mismatch between contemporary and ancestral environments. Key influences on individual differences in patterns of aging and timing of onset of age-related disease remain to be uncovered. This project studies wild-living non-human primates to examine the biological systems that deteriorate with age, and drills down into the mechanisms behind individual differences in the rate of aging. This study contributes valuable comparative data on aging that deepens an understanding of human aging patterns through identifying specific social and life course factors associated with age-related disease. This project supports the training and professional development of a postdoctoral researcher and multiple undergraduate students, local community outreach and engagement, and science outreach in K-12 schools in the U.S.This project builds on over fifteen prior years of data collection on the same populations, which provides a rich context of behavioral and demographic data from over 100 individuals. Social adversity in early life and adulthood, cumulative reproductive effort, and multiple markers of biological aging are included predictors of aging patterns and outcomes. The main aims of the project are to identify: 1) the trajectory of aging across the life course with respect to physical deterioration (as measured by bone and muscle loss), physiological dysregulation (as indexed by hormone and immune markers), and molecular hallmarks of aging, and compare the results with existing datasets on aging from humans and other nonhuman primates; 2) the factors and timing that exert the strongest influence on inter-individual differences in the pace of biological aging, including social status, traumatic changes in social group membership, poor social integration, and increased reproductive effort. By coupling a rich longitudinal dataset with cutting edge methods in physiology, medical imaging, molecular techniques, and comparative methods, this study adds to a small, but growing number of nonhuman primate models of aging in wild populations that can build an informative context for understanding the evolution of, and variation in, human aging and aging-related deterioration.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

人类的寿命在上个世纪已经翻了一番，这与年龄相关疾病的增加有关。这些疾病源于自然年龄相关的身体功能定义，但目前尚不清楚系统之间的定义（例如，骨丢失和免疫学系统功能增加）如何相关。还尚待确定，当代和祖先环境之间的不匹配进一步影响了人类衰老和与年龄相关的疾病的模式。对与年龄相关疾病的衰老模式的个体差异的关键影响尚待发现。该项目研究了野生生活的非人类素数，以检查随着年龄的增长而检测的生物系统，并深入研究了衰老率个体差异背后的机制。这项研究为老化提供了价值比较数据，通过确定与年龄相关疾病相关的特定社会和生命课程因素，加深对人衰老模式的理解。该项目支持博士后研究人员和多个本科生的培训和专业发展，当地社区的外展和参与度以及美国在美国项目中的K-12学校的科学外展，以同一人群的超过15年的数据收集为基础，这为100多个人提供了丰富的行为和人口统计学背景。包括早期和成年期的社交广告，累积的生殖工作以及生物衰老的多个标记，包括衰老模式和结果的预测指标。该项目的主要目的是识别：1）关于身体恶化（通过骨骼和肌肉损失来衡量），身体失调（如Homone和免疫标记索引）以及衰老的分子标志，并将结果与​​现有的数据集进行比较，与来自人类的现有数据集进行了比较； 2）对生物衰老速度的个人间差异产生强大影响的因素和时机，包括社会地位，社会群体成员资格的创伤变化，社会融合不良以及增加的生殖努力。通过将丰富的纵向数据集与生理学，医学成像，分子技术和比较方法中的最先进方法耦合，这项研究增加了野生人群中较少但越来越多的非人类私人衰老模型，可以建立一个信息的信息，以建立一个信息，以理解型号的统计范围，并逐渐确定了统计的宣传。通过基金会的智力优点和更广泛的影响评估标准通过评估来支持。