SBIR Phase II: A Wearable Non-Invasive Deep Tissue Thermometer

SBIR 第二阶段：可穿戴式非侵入式深层组织温度计

• 批准号: 2233629
• 负责人: James Pollock
• 金额: $ 100万
• 依托单位: LUMENASTRA
• 依托单位国家: 美国
• 项目类别: Cooperative Agreement
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-03-15 至 2025-02-28
• 项目状态: 未结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=2233629&HistoricalAwards=false
• 关键词: SBIR; Phase; II; Wearable; Non

The broader impact/commercial potential of this Small Business Innovation Research (SBIR) Phase II project begins with a wearable, non-invasive device providing vital brain and internal organ temperature measurements in a clinical setting that can dramatically reduce mortality and the risk of permanent brain damage for tens of thousands of patients experiencing cardiac and aortic repair surgery. This impact extends to protecting the brain from additional permanent brain injury and lifelong disability for the 4.8 million people hospitalized annually in the US after stroke, cardiac arrest or traumatic brain injury and 1 million infants born with impaired blood-oxygen flow needing constant brain temperature management in their first hours of life. Finally, this technology offers a more consistent and meaningful internal body temperature measurement for millions of consumers through next generation handheld and wearable thermometers monitoring general wellness and providing advanced notice of changes in health conditions. True internal body temperature will be a powerful complement to the inevitable next generation wearable sensors that integrate many health indicators into a comprehensive and actionable snapshot of personal health.This Small Business Innovation Research (SBIR) Phase II project fulfills the more than 30-year expectation that true internal body temperatures providing a meaningful metric of wellness. Such technologies measure extremely small electromagnetic thermal noise radiated from within the body. Through the intersection of disparate microwave technologies and biological science, this novel wearable sensor became possible. Research challenges include the development of a design methodology for an ultra-low noise receiver utilizing a near-field wearable probe, the discovery of efficient interference mitigation techniques, and the development of an algorithm for accurate and fast temperature estimation, all within a low-power wearable package. This project will develop the needed sensitivity, spatial resolution, and mitigation of the significant microwave noise from GPS, Wi-Fi, cellular and other common electronic sources. After leveraging off-the-shelf components in Phase I, the company is moving to miniaturized and specialized chips to meet the application need.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

该小企业创新研究 (SBIR) 第二阶段项目的更广泛影响/商业潜力首先是一款可穿戴、非侵入性设备，可在临床环境中提供重要的大脑和内脏器官温度测量，从而显着降低死亡率和永久性脑损伤的风险数万名接受心脏和主动脉修复手术的患者受到损害。这种影响还包括保护大脑免受额外的永久性脑损伤和终身残疾，美国每年有 480 万人因中风、心脏骤停或创伤性脑损伤而住院，以及 100 万出生时血氧流动受损、需要持续脑部温度管理的婴儿在他们生命的最初几个小时里。最后，该技术通过下一代手持式和​​可穿戴式温度计监测一般健康状况并提前通知健康状况的变化，为数百万消费者提供更一致、更有意义的内部体温测量。真实的内部体温将成为不可避免的下一代可穿戴传感器的有力补充，这些传感器将许多健康指标集成到全面且可操作的个人健康快照中。这个小型企业创新研究 (SBIR) 第二阶段项目实现了 30 多年的期望真实的内部体温提供了有意义的健康指标。 此类技术可测量从体内辐射的极小电磁热噪声。通过不同的微波技术和生物科学的交叉，这种新颖的可穿戴传感器成为可能。 研究挑战包括开发利用近场可穿戴探头的超低噪声接收器的设计方法、发现有效的干扰减轻技术以及开发用于准确和快速温度估计的算法，所有这些都在低电力可穿戴包。该项目将开发所需的灵敏度、空间分辨率，并减轻来自 GPS、Wi-Fi、蜂窝网络和其他常见电子源的显着微波噪声。在第一阶段利用现成组件后，该公司正在转向小型化和专用芯片来满足应用需求。该奖项反映了 NSF 的法定使命，并通过利用基金会的智力优势和更广泛的影响进行评估，认为值得支持审查标准。