SBIR Phase II: A Wearable Non-Invasive Deep Tissue Thermometer

SBIR 第二阶段：可穿戴式非侵入式深层组织温度计

• 批准号: 2233629
• 负责人: James Pollock
• 金额: $ 100万
• 依托单位: LUMENASTRA
• 依托单位国家: 美国
• 项目类别: Cooperative Agreement
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-03-15 至 2025-02-28
• 项目状态: 未结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=2233629&HistoricalAwards=false
• 关键词: SBIR; Phase; II; Wearable; Non

The broader impact/commercial potential of this Small Business Innovation Research (SBIR) Phase II project begins with a wearable, non-invasive device providing vital brain and internal organ temperature measurements in a clinical setting that can dramatically reduce mortality and the risk of permanent brain damage for tens of thousands of patients experiencing cardiac and aortic repair surgery. This impact extends to protecting the brain from additional permanent brain injury and lifelong disability for the 4.8 million people hospitalized annually in the US after stroke, cardiac arrest or traumatic brain injury and 1 million infants born with impaired blood-oxygen flow needing constant brain temperature management in their first hours of life. Finally, this technology offers a more consistent and meaningful internal body temperature measurement for millions of consumers through next generation handheld and wearable thermometers monitoring general wellness and providing advanced notice of changes in health conditions. True internal body temperature will be a powerful complement to the inevitable next generation wearable sensors that integrate many health indicators into a comprehensive and actionable snapshot of personal health.This Small Business Innovation Research (SBIR) Phase II project fulfills the more than 30-year expectation that true internal body temperatures providing a meaningful metric of wellness. Such technologies measure extremely small electromagnetic thermal noise radiated from within the body. Through the intersection of disparate microwave technologies and biological science, this novel wearable sensor became possible. Research challenges include the development of a design methodology for an ultra-low noise receiver utilizing a near-field wearable probe, the discovery of efficient interference mitigation techniques, and the development of an algorithm for accurate and fast temperature estimation, all within a low-power wearable package. This project will develop the needed sensitivity, spatial resolution, and mitigation of the significant microwave noise from GPS, Wi-Fi, cellular and other common electronic sources. After leveraging off-the-shelf components in Phase I, the company is moving to miniaturized and specialized chips to meet the application need.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

这项小型企业创新研究（SBIR）II期项目的更广泛的影响/商业潜力始于可穿戴的非侵入性装置，在临床环境中提供了重要的大脑和内部器官温度测量，可大大降低死亡率，并对经历心脏和主动性维修手术的数十万名患者造成永久性脑损伤的风险。这种影响延伸到保护大脑免受中风，心脏骤停或创伤性脑损伤的480万人的额外永久性脑损伤和终生残疾，以及100万婴儿出生的患有受损的血液氧气流量受损，需要在生命的第一小时内持续的大脑温度管理。最后，这项技术通过下一代手持式和​​可穿戴温度计，为数百万消费者提供了更加一致，有意义的内部温度测量，从而监测一般健康状况，并提供有关健康状况变化的高级通知。真正的内部体温将是对不可避免的下一代可穿戴传感器的有力补充，该传感器将许多健康指标整合到个人健康的全面且可操作的快照中。这项小型企业创新研究（SBIR）II期项目实现了30年以上的期望，即真正的内部身体温度提供了有意义的健康指标。 这样的技术测量了从体内辐射的极小电磁热噪声。通过不同的微波技术和生物科学的交集，这种新颖的可穿戴传感器变得可能成为可能。 研究挑战包括使用近场可穿戴探针的超低噪声接收器的设计方法，发现有效的干扰缓解技术，以及开发算法以进行准确，快速温度估计的算法，所有这些都在低功率可穿戴式套件中。该项目将发展所需的灵敏度，空间分辨率，并减轻GPS，Wi-Fi，Cellular和其他通用电子源的显着微波噪声。在利用了第一阶段的现成组件后，该公司正在采用微型和专业的芯片来满足申请需求。该奖项反映了NSF的法定任务，并被认为是通过基金会的知识分子优点和更广泛的影响评估审查标准来通过评估来获得支持的。