SBIR Phase I: A Wearable Non-Invasive Deep Tissue Thermometer
SBIR 第一阶段:可穿戴式非侵入式深层组织温度计
基本信息
- 批准号:2126774
- 负责人:
- 金额:$ 25.6万
- 依托单位:
- 依托单位国家:美国
- 项目类别:Standard Grant
- 财政年份:2021
- 资助国家:美国
- 起止时间:2021-08-01 至 2022-10-31
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
The broader impact/commercial potential of this Small Business Innovation Research (SBIR) Phase I project is to measure biological temperatures for many important problems in health care, by advancing a novel temperature sensor. In the near term, a wearable, non-invasive sensor can prevent heat stroke and exhaustion for at-risk cohorts, such as the US military, which suffers from 2800 annual cases of heat stroke in active-duty personnel. Furthermore, heat stroke early warning could diminish injuries and deaths among U.S. high school and college athletes and 7.4 million first responders who typically operate under stressful conditions. Beyond heat stress, this thermometer can monitor elevated brain temperature during the critical hours following stroke or traumatic brain injury (affecting 4.8 million patients per year), which can cause additional brain damage and permanent disabilities. The proposed sensor can directly measure tumor temperature during heating therapy, potentially improving clinical outcomes for some of the 1.8 million patients per year by 20-40% while reducing dosage of debilitating chemicals and radiation. This Small Business Innovation Research (SBIR) Phase I project will demonstrate a novel, non-invasive temperature sensor capable of accurately measuring deep tissue temperature several centimeters below the skin, wherever placed. The proposed sensor detects small microwave signals in a noisy environment by incorporating 20+ signal processing and noise reduction methods with technologies similar to those used in radio astronomy. Non-invasive brain temperature measurement is particularly important as the brain generates and manages its own critical operating temperature, and elusive as it can only be inferred from surrogate measurements without directly cutting into the skull. Direct brain temperature monitoring with a wearable device may provide early warning of many health conditions.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.
这项小型企业创新研究(SBIR)I期项目的更广泛的影响/商业潜力是通过推进新型温度传感器来衡量许多重要问题的生物温度。 在短期内,一个可穿戴的非侵入性传感器可以防止处于风险的同类群体(例如美国军方)的疲惫,该军队每年有2800例现役人员中风案例。 此外,中风预警可能会减少美国高中和大学运动员的伤害和死亡,以及740万急救人员通常在压力大的情况下进行操作。除了热应力之外,该温度计还可以监测中风或脑部损伤的关键小时内(每年影响480万患者)的脑温度升高,这可能会导致额外的脑损伤和永久性残疾。拟议的传感器可以在加热疗法期间直接测量肿瘤温度,每年180万患者中的某些患者中的某些人可能会提高20-40%的临床结果,同时减少衰弱的化学物质和辐射剂量。 这项小型企业创新研究(SBIR)I期项目将展示一种新型的非侵入性温度传感器,能够准确测量在皮肤下方(无论放置的位置)以下几厘米的深层组织温度。提出的传感器通过将20+信号处理和降噪方法与类似于射电天文学中使用的技术相似,从而在嘈杂的环境中检测到小的微波信号。非侵入性大脑温度测量特别重要,因为大脑会产生并管理其自身的关键工作温度,并且难以捉摸,因为它只能从替代测量中推断而不直接切入头骨。使用可穿戴设备的直接大脑温度监测可能会提供许多健康状况的预警。该奖项反映了NSF的法定任务,并被认为是值得通过基金会的知识分子优点和更广泛影响的审查标准来评估值得支持的。
项目成果
期刊论文数量(3)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
A Hybrid Correlation-Dicke Radiometer for Internal Body Thermometry
用于体内测温的混合相关迪克辐射计
- DOI:10.23919/eumc54642.2022.9924276
- 发表时间:2022
- 期刊:
- 影响因子:0
- 作者:Lee, Jooeun;Botello, Gabriel Santamaria;Streeter, Robert;Hall, Kaitlin;Popovic, Zoya
- 通讯作者:Popovic, Zoya
Near-Field Antenna for Noninvasive Human Head Microwave Thermometry
用于无创人体头部微波测温的近场天线
- DOI:10.1109/ap-s/usnc-ursi47032.2022.9886962
- 发表时间:2022
- 期刊:
- 影响因子:0
- 作者:Hall, Kaitlin L.;Streeter, Robert;Popovic, Zoya
- 通讯作者:Popovic, Zoya
Correlation Radiometry for Subcutaneous Temperature Measurements
用于皮下温度测量的相关辐射测量
- DOI:10.1109/jerm.2021.3120320
- 发表时间:2021
- 期刊:
- 影响因子:0
- 作者:Streeter, Rob;Santamaria, Gabriel;Hall, Kaitlin;Popovic, Zoya
- 通讯作者:Popovic, Zoya
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James Pollock其他文献
298 Much Ado About Nothing!!! Hold Sirolimus Before Even a Minor Procedure
- DOI:
10.1053/j.ajkd.2020.02.300 - 发表时间:
2020-04-01 - 期刊:
- 影响因子:
- 作者:
James Pollock;Barry Wood;Jesse P. Kelly - 通讯作者:
Jesse P. Kelly
309 Non-Invasive Post-Kidney Transplant Monitoring Tools versus Invasive C4d-Negative Conventional Biopsy for Antibody-Mediated Rejection–Case Reports
- DOI:
10.1053/j.ajkd.2020.02.311 - 发表时间:
2020-04-01 - 期刊:
- 影响因子:
- 作者:
James Pollock;Barry Wood;Jesse P. Kelly - 通讯作者:
Jesse P. Kelly
303 Culture Negative Acute Pyelonephritis Complicated by Acute Kidney Injury Requiring Renal Replacement Therapy
- DOI:
10.1053/j.ajkd.2020.02.305 - 发表时间:
2020-04-01 - 期刊:
- 影响因子:
- 作者:
James Pollock;Barry Wood;Jesse P. Kelly - 通讯作者:
Jesse P. Kelly
312 Development of an Integrated End-Stage Kidney Disease Care Coordination Model: A Randomized Controlled Trial Protocol
- DOI:
10.1053/j.ajkd.2020.02.314 - 发表时间:
2020-04-01 - 期刊:
- 影响因子:
- 作者:
James Pollock;Barry Wood;Jesse P. Kelly - 通讯作者:
Jesse P. Kelly
314 Efficacy of Tenapanor for the Control of Serum Phosphorus in Patients with CKD on Dialysis: Novel Mechanism of Action Allows for Both Monotherapy and Dual Mechanism Approach
- DOI:
10.1053/j.ajkd.2020.02.316 - 发表时间:
2020-04-01 - 期刊:
- 影响因子:
- 作者:
James Pollock;Barry Wood;Jesse P. Kelly - 通讯作者:
Jesse P. Kelly
James Pollock的其他文献
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{{ truncateString('James Pollock', 18)}}的其他基金
SBIR Phase II: A Wearable Non-Invasive Deep Tissue Thermometer
SBIR 第二阶段:可穿戴式非侵入式深层组织温度计
- 批准号:
2233629 - 财政年份:2023
- 资助金额:
$ 25.6万 - 项目类别:
Cooperative Agreement
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