SBIR Phase I: A Wearable Non-Invasive Deep Tissue Thermometer

SBIR 第一阶段：可穿戴式非侵入式深层组织温度计

• 批准号: 2126774
• 负责人: James Pollock
• 金额: $ 25.6万
• 依托单位: LUMENASTRA
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-08-01 至 2022-10-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=2126774&HistoricalAwards=false
• 关键词: SBIR; Phase; Wearable; Non; Invasive

The broader impact/commercial potential of this Small Business Innovation Research (SBIR) Phase I project is to measure biological temperatures for many important problems in health care, by advancing a novel temperature sensor. In the near term, a wearable, non-invasive sensor can prevent heat stroke and exhaustion for at-risk cohorts, such as the US military, which suffers from 2800 annual cases of heat stroke in active-duty personnel. Furthermore, heat stroke early warning could diminish injuries and deaths among U.S. high school and college athletes and 7.4 million first responders who typically operate under stressful conditions. Beyond heat stress, this thermometer can monitor elevated brain temperature during the critical hours following stroke or traumatic brain injury (affecting 4.8 million patients per year), which can cause additional brain damage and permanent disabilities. The proposed sensor can directly measure tumor temperature during heating therapy, potentially improving clinical outcomes for some of the 1.8 million patients per year by 20-40% while reducing dosage of debilitating chemicals and radiation. This Small Business Innovation Research (SBIR) Phase I project will demonstrate a novel, non-invasive temperature sensor capable of accurately measuring deep tissue temperature several centimeters below the skin, wherever placed. The proposed sensor detects small microwave signals in a noisy environment by incorporating 20+ signal processing and noise reduction methods with technologies similar to those used in radio astronomy. Non-invasive brain temperature measurement is particularly important as the brain generates and manages its own critical operating temperature, and elusive as it can only be inferred from surrogate measurements without directly cutting into the skull. Direct brain temperature monitoring with a wearable device may provide early warning of many health conditions.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

该小企业创新研究 (SBIR) 第一阶段项目的更广泛影响/商业潜力是通过改进新型温度传感器来测量医疗保健中许多重要问题的生物温度。 短期内，可穿戴式非侵入式传感器可以预防高危人群中暑和疲劳，例如美国军队，每年有 2800 例现役人员中暑。 此外，中暑早期预警可以减少美国高中和大学运动员以及 740 万通常在压力条件下工作的急救人员的伤害和死亡。除了热应激之外，这款温度计还可以监测中风或脑外伤（每年影响 480 万名患者）后关键时间内升高的脑部温度，这可能会导致额外的脑损伤和永久性残疾。所提出的传感器可以在加热治疗期间直接测量肿瘤温度，有可能将每年 180 万患者中的一些患者的临床结果改善 20-40%，同时减少使人衰弱的化学物质和辐射的剂量。 这个小型企业创新研究 (SBIR) 第一阶段项目将展示一种新型非侵入性温度传感器，无论放置在何处，都能够准确测量皮肤下几厘米的深层组织温度。该传感器通过将 20 多种信号处理和降噪方法与射电天文学中使用的技术相结合，在嘈杂的环境中检测小微波信号。无创脑部温度测量尤其重要，因为大脑会产生并管理其自身的临界工作温度，但也难以捉摸，因为它只能通过替代测量来推断，而无需直接切入头骨。使用可穿戴设备进行直接脑部温度监测可以对许多健康状况提供早期预警。该奖项反映了 NSF 的法定使命，并通过使用基金会的智力优点和更广泛的影响审查标准进行评估，被认为值得支持。

项目成果

A Hybrid Correlation-Dicke Radiometer for Internal Body Thermometry

用于体内测温的混合相关迪克辐射计

• DOI: 10.23919/eumc54642.2022.9924276
• 发表时间: 2022
• 期刊: 2022 52nd European Microwave Conference (EuMC
• 作者: Lee, Jooeun;Botello, Gabriel Santamaria;Streeter, Robert;Hall, Kaitlin;Popovic, Zoya
• 通讯作者: Popovic, Zoya

Near-Field Antenna for Noninvasive Human Head Microwave Thermometry

用于无创人体头部微波测温的近场天线

• DOI: 10.1109/ap-s/usnc-ursi47032.2022.9886962
• 发表时间: 2022
• 期刊: 2022 IEEE International Symposium on Antennas and Propagation and USNC-URSI Radio Science Meeting (AP-S/URSI
• 作者: Hall, Kaitlin L.;Streeter, Robert;Popovic, Zoya
• 通讯作者: Popovic, Zoya

Correlation Radiometry for Subcutaneous Temperature Measurements

用于皮下温度测量的相关辐射测量

• DOI: 10.1109/jerm.2021.3120320
• 发表时间: 2021
• 期刊: RF and Microwaves in Medicine and Biology
• 作者: Streeter, Rob;Santamaria, Gabriel;Hall, Kaitlin;Popovic, Zoya
• 通讯作者: Popovic, Zoya