PIRE: Synthesis of Optical Materials for Bioapplications: Research, Education, Recruitment and Outreach (SOMBRERO)

PIRE：生物应用光学材料的合成：研究、教育、招聘和推广 (SOMBRERO)

• 批准号: 2232111
• 负责人: Guillermo Aguilar
• 金额: $ 360.14万
• 依托单位: Texas A&M University
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-07-01 至 2023-09-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=2232111&HistoricalAwards=false
• 关键词: PIRE; Synthesis; Optical; Materials; Bioapplications

PIRE: Synthesis of Optical Materials for Bioapplications: Research, Education, Recruitment and Outreach (SOMBRERO). PI: Guillermo Aguilar, University of California, Riverside (UCR)Non-Technical Abstract: This award grant provides funding for the development of an international partnership for research and education between UCR - one of America's few research-intensive Hispanic Serving Institutions (HSI) - and three premier institutions in México: Centro de Investigación Científica y Educación Superior de Ensenada (CICESE) in Ensenada; Universidad Nacional Autónoma de México (UNAM) in Mexico City; and Instituto Nacional de Astrofísica, Óptica y Electrónica (INAOE) in Puebla. SOMBRERO aims at further developing the concept of a transparent cranial implant made of nanocrystalline yttria-stabilized-zirconia (nc-YSZ) - the so called Windows to the Brain (WttB) platform - to replace portions of the skull and thus allow non-invasive optical interrogation of the brain facilitating the diagnosis and treatment of a wide variety of brain pathologies and neurological disorders, such as traumatic brain injury and stroke. Although a number of materials (e.g., titanium, alumina, acrylic, etc.) have been evaluated for use in cranial reconstruction, none provide the requisite combination of properties required for clinically-viable transparent implants. Our preliminary efforts have already demonstrated that nc-YSZ offers significant promise in this regard. Furthermore, the educational component of this award aims at jointly training students from the US and México in line with various current education policy initiatives in both countries, including: a) the Brain Research through Advancing Innovative Neurotechnologies (BRAIN) initiative, as well as the "100,000 strong in the Americas" initiative to increase study in Latin America and the Caribbean, among others in México and within the UC system. SOMBRERO's innovations will provide a new neurotechnology platform that will eventually serve as a critical enabler for longitudinal studies of the brain, as well as the development of a host of emerging laser-based diagnostic and therapeutic techniques for neurological disorders. Concurrently, SOMBRERO will provide research opportunities to a diverse cadre of US students, preparing them to innovate as independent, globally engaged engineers. TechnicalThis study encompasses international collaborative research between UCR and three premier institutions in México: Centro de Investigación Científica y Educación Superior de Ensenada (CICESE) in Ensenada; Universidad Nacional Autónoma de México (UNAM) in Mexico City; and Instituto Nacional de Astrofísica, Óptica y Electrónica (INAOE) in Puebla. So far, these collaborations have produced numerous advances in opto-ceramics. Particularly noteworthy is the recent report of the first transparent nanocrystalline yttria-stabilized-zirconia (nc-YSZ) cranial implants capable of replacing portions of the skull to allow non-invasive optical interrogation of the brain on an ongoing recurring basis, i.e. the Windows to the Brain (WttB) platform, which is the primary integrative technology goal of the project. The significance of SOMBRERO lies in the potential the WttB platform may eventually afford for: a) advancing understanding of the brain, by facilitating the clinical translation of emerging optogenetic neurotechnologies under development in the BRAIN Initiative; and b) facilitating the diagnosis and treatment of a wide variety of brain pathologies and neurological disorders, such as traumatic brain injury and stroke. Although a number of materials (e.g., titanium, alumina, acrylic, etc.) have been evaluated for use in cranial reconstruction, none provide the requisite combination of properties required for clinically-viable transparent implants. As such, this award proposes to take the next steps towards clinical translation of the WttB concept by advancing both our fundamental understanding and technological capabilities within this context. SOMBRERO's innovations will provide a new neurotechnology platform that will eventually serve as a critical enabler for longitudinal studies of the brain, as well as the development of a host of emerging laser-based diagnostic and therapeutic techniques for neurological disorders. The impact of SOMBRERO will lie in the unique capabilities it will provide to the neuroscience community, which will advance understanding and improve disease management, thus improving quality of life and reducing healthcare costs. Furthermore, the advances made in the science and technology of novel opto-ceramics will have potential to extend to numerous other fields, including medical lasers, defense, energy, etc. Finally, SOMBRERO will recruit UCR STEM students in multiple disciplines for training in both countries, and build upon UCR's strong record of minority undergraduate retention and graduate recruitment by leveraging well-established programs and student organizations, such as the California Alliance for Minority Participation (CAMP), UC Leadership Excellence through Advanced Degrees (UC LEADS), and the Society for Hispanic Professional Engineers (SHPE).

PIRE：生物申请的光学材料的合成：研究，教育，招聘和外展（Sombrero）。 PI：加利福尼亚大学河滨分校（UCR）非技术摘要的Guillermo Aguilar：该奖项赠款为UCR之间的国际研究和教育伙伴关系提供了资金，UCR是美国少数几个研究密集型西班牙裔西班牙裔美国人服务机构之一（HSI）（HSI）和Ménodecose的前三个机构（HSI），以及以前的三个机构。墨西哥城的NacionalAutónomadeMéxico（UNAM）；以及普埃布拉（Puebla）的Electrónica（Inaoe）的Nacional deAstrofísicaInstituto。 sombrero旨在进一步发展由纳米晶体的透明颅骨植入物的概念脑损伤和中风。尽管已经评估了许多材料（例如钛，氧化铝，丙烯酸等）用于颅骨重建，但没有一个提供临床可行透明实现所需的属性的组合。我们的初步努力已经表明，NC-YSZ在这方面提供了巨大的希望。此外，该奖项的教育组成部分旨在共同培训来自美国和墨西哥的学生，符合两国当前的各种教育政策计划，包括：a）通过推进创新的神经技术（Brain）倡议的大脑研究，以及“在美国的100,000个强大的倡议”以及在拉丁美洲和其他国家中增加了“ 100,000个强大的研究”，以及其他涉及Mebebean和Mebe的计划。 Sombrero的创新将提供一个新的神经技术平台，该平台最终将成为大脑纵向研究的关键推动者，以及开发许多基于激光的神经系统疾病的新兴激光诊断和治疗技术。同时，Sombrero将为美国学生的多样性干部提供研究机会，为他们作为独立的，全球敬业的工程师的创新做好准备。技术这项研究涵盖了墨西哥的UCR与三个主要机构之间的国际合作研究：Ensenada的Centro de Resjuctionun superior de Ensenada（CICESE）；墨西哥城的NacionalAutónomadeMéxico（UNAM）；以及普埃布拉（Puebla）的Electronica（Inaoe）和eartofísica研究所。到目前为止，这些合作在光学陶瓷方面取得了许多进步。 Particularly noteworthy is the recent report of the first transparent nanocrystalline yttria-stabilized-zirconia (nc-YSZ) cranial impranations capable of replacing portions of the skull to allow non-invasive optical interrogation of the brain on an ongoing recurring basis, i.e. the Windows to the Brain (WttB) platform, which is the primary integrative technology goal of the project. sombrero的意义在于WTTB平台最终可能提供的潜力：a）通过支持大脑倡议中正在开发的新兴光遗传学神经技术的临床翻译来提高对大脑的了解； b）支持多种脑部病理和神经系统疾病（例如脑损伤和中风）的诊断和治疗。尽管已经评估了许多材料（例如钛，氧化铝，丙烯酸等）用于颅骨重建，但没有一个提供临床可行透明实现所需的属性的组合。因此，该奖项提案旨在通过在这种情况下促进我们的基本理解和技术能力来迈出WTTB概念临床翻译的下一步。 Sombrero的创新将提供一个新的神经技术平台，该平台最终将成为大脑纵向研究的关键推动者，以及开发许多基于激光的神经系统疾病的新兴激光诊断和治疗技术。 Sombrero的影响将在于它将为神经科学社区提供的独特功能，这将提高理解和改善疾病管理，从而改善生活质量并降低医疗保健成本。此外，新型光学陶瓷的科学和技术的进步将有可能扩展到其他许多领域，包括医疗激光器，国防，能量等。最后，Sombrero将在两个国家 /地区招募多个训练中的UCR Stem学生，以在两个国家进行多个学科，并以UCR的少数群体招募和毕业的招聘为少数派的良好记录，从而促进了少数阶层的招募和毕业生，并在上面招募了良好的学生，并培养了良好的学生，并以良好的培训为生，并以良好的培训为生，并以良好的培训为生，并以良好的培训为生，并以较小的招聘为生。 （CAMP），UC通过高级学位（UC Leads）和西班牙裔专业工程师协会（SHPE）卓越的领导力。