Portable Perfusion Monitor Team for National I-Corps Program

国家 I-Corps 计划便携式灌注监测团队

• 批准号: 1844637
• 负责人: Guillermo Aguilar
• 金额: $ 5万
• 依托单位: University of California-Riverside
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-10-01 至 2020-03-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1844637&HistoricalAwards=false
• 关键词: Portable; Perfusion; Monitor; Team; National

The broader impact/commercial potential of this I-Corps project, based on a portable blood perfusion monitor, lies in its likelihood of reaching new markets and applications beyond current blood perfusion monitor systems. This could have a significant societal impact, as this technology's lower cost compared to other available systems will allow for more routine blood perfusion monitoring (e.g. in preventative medicine), which could improve public health. Further, the compactness and portability of this technology, along with its related elimination of the need for a standalone diagnostic technician, makes its use in healthcare applications in remote and field locations highly feasible. Due to the potential to reach new customers and applications, this technology could be disruptive by addressing unmet needs in diagnostic medicine.This I-Corps project is based around a portable blood perfusion monitor device. The device uses laser speckle imaging technology, which images blood flow non-invasively by reflecting low-power laser light off of tissue and into a camera. By capturing several images in rapid succession and comparing the frames, regions with relative motion (in this case, blood flow) can be visually mapped onto an image of the tissue. The intellectual merit of this portable perfusion device is that it utilizes a new method of processing the data to compare the sequential frames, this new method requiring substantially lower computing power than existing methods. As a result, mini-processors can be used in place of full computer processors, allowing for miniaturization of the device and reduction of the material costs. As well, the device is capable of attaching to existing surgical equipment and functions in real time during surgery, shortening time needed for the surgical process and improving timeliness and quality of associated data. Various prototypes of this device have been tested in mice, and the results demonstrate the ability of this device to provide detailed maps of blood flow, including micro-vessels.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

该I-Corps项目的更广泛的影响/商业潜力，基于便携式血液灌注监测仪，其可能性可能是在当前的血液灌注监测仪系统之外进入​​新市场和应用。这可能会产生重大的社会影响，因为与其他可用系统相比，该技术的成本较低，可以进行更多常规的血液灌注监测（例如，在预防医学中）可以改善公共卫生。此外，这项技术的紧凑性和可移植性以及对独立诊断技术人员的需求相关的消除，使其在非常可行的偏远和现场位置的医疗保健应用中使用。由于有可能吸引新客户和应用程序，该技术可能会通过满足诊断医学的未满足需求而破坏。该I-Corps项目基于便携式血液灌注监测器设备。该设备使用激光斑点成像技术，该技术通过将低功率激光从组织中反射出来并进入相机中，从而无创地图像血液流动。通过快速捕获几个图像并比较框架，可以在视觉上映射具有相对运动的区域（在这种情况下为血流）。该便携式灌注设备的智力优点在于，它利用了一种处理数据来比较顺序帧的新方法，这种新方法需要比现有方法大大降低计算能力。结果，可以使用迷你处理器代替完整的计算机处理器，从而使设备的小型化并降低了材料成本。同样，该设备能够在手术期间实时附加到现有的手术设备和功能上，手术过程所需的缩短时间以及提高相关数据的及时性和质量。该设备的各种原型已经在小鼠中进行了测试，结果证明了该设备提供详细的血流图，包括微容器（包括微型船尾）的能力。该奖项反映了NSF的法定任务，并被认为是通过基金会的知识分子优点和更广泛影响的审查标准来通过评估来获得支持的。