MRI: Acquisition of an Ultra High Performance Liquid Chromatograph with a Tandem High Resolution Mass Spectrometer for Research and Training in Basic and Applied Sciences

MRI：购买带有串联高分辨率质谱仪的超高性能液相色谱仪，用于基础和应用科学的研究和培训

• 批准号: 2216092
• 负责人: Mengliang Zhang
• 金额: $ 25.27万
• 依托单位: Middle Tennessee State University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-08-15 至 2025-07-31
• 项目状态: 未结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=2216092&HistoricalAwards=false
• 关键词: MRI; Acquisition; Ultra; Performance; Liquid

This award is jointly supported by the Major Research Instrumentation and the Chemistry Research Instrumentation Programs. Middle Tennessee State University is acquiring an ultra high performance liquid chromatograph with a tandem high resolution mass spectrometer (UHPLC MS) to support the research of Professor Mengliang Zhang and colleagues Andrienne Friedli, Ngee-Sing Chong, Tony Johnston, and Ying Gao. This instrument facilitates research in the areas of forensics, medicinal, organic, agricultural and materials chemistry. UHPLC MS is an analytical instrument that combines the physical separation capabilities of liquid chromatography with the mass analysis capabilities of mass spectrometry. In general, mass spectrometry (MS) is one of the key analytical methods used to identify and characterize small quantities of chemical species embedded in complex samples. In a typical experiment, the components are heated and flow into a mass spectrometer where they are ionized. The ions' masses are measured very accurately. This highly sensitive technique allows the structure of molecules in complex mixtures to be studied. An instrument with a liquid chromatograph can separate mixtures of compounds before they reach the mass spectrometer. The various ionization sources provide added flexibility with regard to the types of samples that are analyzed. The acquisition strengthens the research infrastructure at the University and regional area. This instrument enhances the educational, research, and teaching efforts of students at all levels in many departments as well as provides accessibility for use at nearby institutions. The instrument will be used to trains a student population with large proportions of women and people from ethnic groups that are underrepresented in the chemical sciences. The proportion of students from low-income backgrounds and those who are first-generation college students across the university lend credence to the ability of the project to influence the participation of such students in STEM. The instrument gives students experience using vital instrumentation that they carry with them into their careers.The award of this mass spectrometer is aimed at enhancing research and education at all levels. It especially impacts areas including forensics, medicinal, organic, agricultural and materials chemistry. Research is focused on the screening of chemical profiles and determining characteristics for chemical identification, the identification of biomarkers, drug discovery, development of synthetic products as anti-fungal, anti-inflammatory, and anti-cancer agents, detailed understanding of fermentation and phytochemical transformation, and the sequencing of peptoids.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

该奖项由重大研究仪器项目和化学研究仪器项目联合资助。中田纳西州立大学正在购买一台配有串联高分辨率质谱仪 (UHPLC MS) 的超高效液相色谱仪，以支持张孟良教授及其同事 Andrienne Friedli、Ngee-Sing Chong、Tony Johnston 和 Ying Gaus 的研究。该仪器促进了法医学、医学、有机、农业和材料化学领域的研究。 UHPLC MS是一种结合了液相色谱的物理分离能力和质谱的质量分析能力的分析仪器。一般来说，质谱 (MS) 是用于识别和表征复杂样品中少量化学物质的关键分析方法之一。在典型的实验中，组分被加热并流入质谱仪，在那里它们被电离。离子质量的测量非常精确。这种高度灵敏的技术可以研究复杂混合物中的分子结构。带有液相色谱仪的仪器可以在化合物混合物到达质谱仪之前对其进行分离。各种电离源为分析样品的类型提供了更大的灵活性。此次收购加强了大学和地区的研究基础设施。该工具增强了许多院系各级学生的教育、研究和教学工作，并为附近机构提供了使用便利。该仪器将用于培训学生群体，其中女性和化学科学领域代表性不足的族裔群体占很大比例。全校低收入背景的学生和第一代大学生的比例证明了该项目有能力影响此类学生参与 STEM。该仪器为学生提供了使用他们在职业生涯中随身携带的重要仪器的经验。该质谱仪的获奖旨在加强各个层面的研究和教育。它尤其影响法医学、医学、有机、农业和材料化学等领域。研究重点是化学特征的筛选和化学鉴定特征的确定、生物标志物的鉴定、药物发现、抗真菌、抗炎和抗癌剂等合成产品的开发、发酵和植物化学转化的详细了解该奖项反映了 NSF 的法定使命，并通过使用基金会的智力价值和更广泛的影响审查标准进行评估，被认为值得支持。