SBIR Phase II: Brillouin Microscopy for Early Detection of Dental Caries

SBIR 第二阶段：用于早期发现龋齿的布里渊显微镜

• 批准号: 2212766
• 负责人: Brecken Blackburn
• 金额: $ 99.74万
• 依托单位: MSTATT LLC
• 依托单位国家: 美国
• 项目类别: Cooperative Agreement
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-01-15 至 2024-12-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=2212766&HistoricalAwards=false
• 关键词: SBIR; Phase; II; Brillouin; Microscopy

The broader impact/commercial potential of this Small Business Innovation Research (SBIR) Phase II project will be to facilitate effective use of tooth remineralization treatments by introducing a new tool that is both highly sensitive to demineralization and robust to confounding factors. If patients are compliant with the generally recommended dental visit schedule of twice a year, it is conceivable that the patient may never need to have a primary filling again. This change in practice has significant patient, dentist and broader economic benefits. The remineralization treatment may increase the number of patients who visit their dentist on a regular basis as they can avoid dreaded fillings. The savings from reducing the time spent on primary filings will provide dentists with the opportunity to take on new patients and procedures, while reducing more mundane drilling activities. This Small Business Innovation Research Phase II project will build on the technology developed for early dental caries detection and will develop the technology for clinical use and evaluation by dentists. This technology will enable dentists and hygienists to diagnose caries earlier than previously possible, enabling early treatment, and significantly reducing the amount of drilling in dentistry. This Phase II project will develop a probe designed for use in dental offices, a miniaturized and a ruggedized Brillouin spectrometer. The project will also conduct lab and user testing, develop software, and develop a scientific version of the spectrometer. At the end of this Phase II effort, a validated prototype that will be ready for a clinical trial is expected.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

该小企业创新研究 (SBIR) 第二阶段项目的更广泛影响/商业潜力将是通过引入一种对脱矿质高度敏感且对混杂因素具有鲁棒性的新工具，促进牙齿再矿化治疗的有效使用。如果患者遵守通常建议的每年两次的牙科就诊时间表，可以想象患者可能永远不需要再次进行初次补牙。这种实践上的改变对患者、牙医和更广泛的经济效益具有重大意义。再矿化治疗可能会增加定期去看牙医的患者数量，因为他们可以避免可怕的补牙。减少初次申请所花费的时间所节省的时间将为牙医提供接受新患者和新手术的机会，同时减少更多普通的钻孔活动。这个小企业创新研究第二阶段项目将以早期龋齿检测开发的技术为基础，并将开发供牙医临床使用和评估的技术。这项技术将使牙医和保健人员能够比以前更早地诊断龋齿，从而实现早期治疗，并显着减少牙科钻孔量。该第二阶段项目将开发一种专为牙科诊所使用的探头、一种小型化且坚固耐用的布里渊光谱仪。该项目还将进行实验室和用户测试、开发软件并开发光谱仪的科学版本。在第二阶段工作结束时，预计将有一个经过验证的原型可供临床试验使用。该奖项反映了 NSF 的法定使命，并通过使用基金会的智力优点和更广泛的影响审查标准进行评估，被认为值得支持。