PFI TT: A hand-held device for rapid and accurate determination of cancerous tumor margins during surgical resections

PFI TT：一种手持式设备，用于在手术切除过程中快速准确地确定癌性肿瘤边缘

• 批准号: 2141183
• 负责人: Dong-Shik Kim
• 金额: $ 25万
• 依托单位: University of Toledo
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-02-01 至 2024-12-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=2141183&HistoricalAwards=false
• 关键词: PFI; TT; hand; held; device

The broader impact/commercial potential of this Partnerships for Innovation - Technology Translation (PFI-TT) project improves outcomes for cancer patients. The proposed research will develop a hand-held device that helps surgeons rapidly and accurately determine the marginal areas around the tumor during surgery. Correct tumor removal (known as resection) reduces the surgical time, the recovery time, and the risk of subsequent surgeries. The proposed technology will reduce cost and improve outcomes. The proposed project will demonstrate a hand-held sensor device that rapidly and accurately determines the resection area around a tumor during surgery. Identifying and verifying the resection perimeter can be challenging, and inaccurate determination of tumor margins can lead to subsequent surgeries. The proposed research will investigate: 1) rapid, accurate and consistent measurement of hydroxyl radicals as a biomarker for active tumor growth, and 2) the relationship between hydroxyl radical concentrations and the cancer stage of progression. The project will design and optimize the sensor tip and electrode composition and geometry to minimize noise; it will further validate the data with in vitro tests using 3-D spheroids matrixes with varying hydroxyl radical levels.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

该创新合作伙伴关系 - 技术转化 (PFI-TT) 项目具有更广泛的影响/商业潜力，可改善癌症患者的治疗结果。拟议的研究将开发一种手持设备，帮助外科医生在手术过程中快速准确地确定肿瘤周围的边缘区域。正确的肿瘤切除（称为切除术）可以减少手术时间、恢复时间和后续手术的风险。拟议的技术将降低成本并改善结果。拟议的项目将展示一种手持式传感器设备，可在手术过程中快速准确地确定肿瘤周围的切除区域。识别和验证切除周长可能具有挑战性，并且肿瘤边缘确定不准确可能会导致后续手术。 拟议的研究将调查：1）快速、准确和一致地测量羟自由基作为活跃肿瘤生长的生物标志物，2）羟自由基浓度与癌症进展阶段之间的关系。该项目将设计和优化传感器尖端和电极的成分和几何形状，以最大限度地减少噪音；它将使用具有不同羟自由基水平的 3-D 球体基质通过体外测试进一步验证数据。该奖项反映了 NSF 的法定使命，并通过使用基金会的智力价值和更广泛的影响审查标准进行评估，被认为值得支持。

项目成果

A Novel Electrochemical Sensor Based on a Cerium Oxide/Gold/Carbon Nanocompositefor the Detection of Hydroxyl Free Radicals

基于氧化铈/金/碳纳米复合材料的新型电化学传感器，用于检测羟基自由基

• DOI: 10.1149/1945-7111/acca4c
• 发表时间: 2023-04
• 期刊: Journal of The Electrochemical Society
• 影响因子: 3.9
• 作者: Ghaedamini, Hamidreza;Alba;Kim, Dong
• 通讯作者: Kim, Dong