I-Corps: A Novel Injectable Bone Healing Gel Device

I-Corps：一种新型可注射骨愈合凝胶装置

• 批准号: 2040076
• 负责人: Dong-Shik Kim
• 金额: $ 5万
• 依托单位: University of Toledo
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-08-15 至 2022-09-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=2040076&HistoricalAwards=false
• 关键词: Corps; Novel; Injectable; Bone; Healing

The broader impact/commercial potential of this I-Corps project is to define the requirements for the development of natural polysaccharide (sugar)-based gel devices for bone healing. There has been a recent, sharp increase in the number of orthopedic surgeries worldwide; This is due to the increased aging population with orthopedic diseases and the rising incidence of road accidents. In addition, the increased number of obesity and osteoporosis patients are accompanied with high incidence of bone fracture. Currently available treatments including autografts, allografts, bone graft substitutes (BGSs), and bone morphogenetic proteins (BMPs) suffer from many drawbacks. The proposed gel consists of a natural polysaccharide that as been shown to promote rapid bone growth through osteoconductive and vascularizing effects. In addition, an associated anti-bacterial property is considered an important advantage as more than 70% of patients with fractures in distal extremities suffer from infection that requires treatment. The translation of the proposed gel device is expected to help the patients recover faster without infection. In addition, the treatment may be more cost-effective than the BGSs and BMPs available in the market. The global market is estimated to be the $3.25 billion for treating fractures in distal extremities.This I-Corps project is based on the translation of developments for natural polysaccharide gel devices for bone healing. The device consists of gellan gum and FDA-approved components that demonstrate strong osteoconductive and angiogenetic activities for rapid bone healing with anti-bacterial effects. The current treatments for bone defects are autografts, allografts, bone graft substitutes (BGSs), and bone morphogenetic protein-2 (BMP-2). These methods often suffer from problems such as immuno-rejection, disease transmission, weak bone-forming potency, abnormal bone outgrowth, inflammation, and tumorigenesis. In a recent animal study with the proposed gel, it was found that the gel induced significant cortical bone ingrowth and thickened cortical bones at the injection sites. In addition, there was a significant increase in neovascularization within the cortical bones. Two major advantages of the device over the current bone healing devices available in the market are its ability to induce bone growth inwardly and suppress tumorous cell growth. Additionally, the anti-bacterial activity of the device is an improvement because bone fracture-related infection delays healing and increases complications and medical costs.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

该 I-Corps 项目更广泛的影响/商业潜力是确定开发用于骨愈合的天然多糖（糖）凝胶装置的要求。最近，全球骨科手术数量急剧增加；这是由于患有骨科疾病的人口老龄化加剧以及道路交通事故发生率上升。此外，肥胖和骨质疏松症患者数量的增加也伴随着骨折发生率的升高。目前可用的治疗方法包括自体移植物、同种异体移植物、骨移植替代品（BGS）和骨形态发生蛋白（BMP），但存在许多缺点。所提出的凝胶由天然多糖组成，已被证明可以通过骨传导和血管化作用促进骨骼快速生长。此外，相关的抗菌特性被认为是一个重要的优势，因为超过 70% 的四肢远端骨折患者患有需要治疗的感染。所提出的凝胶装置的翻译预计将帮助患者更快地康复而不会感染。此外，该治疗可能比市场上现有的 BGS 和 BMP 更具成本效益。全球用于治疗远端四肢骨折的市场估计为 32.5 亿美元。这个 I-Corps 项目基于用于骨愈合的天然多糖凝胶装置的开发成果的转化。该装置由结冷胶和 FDA 批准的成分组成，具有强大的骨传导和血管生成活性，可实现骨骼快速愈合并具有抗菌作用。目前骨缺损的治疗方法有自体移植、同种异体移植、骨移植替代品（BGS）和骨形态发生蛋白-2（BMP-2）。这些方法常常存在免疫排斥、疾病传播、成骨能力弱、骨生长异常、炎症和肿瘤发生等问题。在最近对所提出的凝胶进行的一项动物研究中，发现该凝胶可诱导显着的皮质骨向内生长，并使注射部位的皮质骨增厚。此外，皮质骨内的新血管形成显着增加。与市场上现有的骨愈合设备相比，该设备的两大优势是其能够诱导骨向内生长并抑制肿瘤细胞生长。此外，该设备的抗菌活性也得到了改善，因为骨折相关的感染会延迟愈合并增加并发症和医疗费用。该奖项反映了 NSF 的法定使命，并通过使用基金会的智力优势和更广泛的评估进行评估，被认为值得支持。影响审查标准。

项目成果

Polysaccharide-Based Composite Scaffolds for Osteochondral and Enthesis Regeneration

用于骨软骨和附着点再生的多糖复合支架

• DOI: 10.1089/ten.teb.2022.0114
• 发表时间: 2022-10
• 期刊: Tissue Engineering Part B: Reviews
• 作者: Baawad, Abdullah;Jacho, Diego;Hamil, Taijah;Yildirim;Kim, Dong
• 通讯作者: Kim, Dong